Asian Journal of Andrology Advance online publication Articleswww.asiaandro.com陔恓www.asiaandro.comzh-CNwww.asiaandro.comNLRP3 activation by lipopolysaccharide (LPS) mediates the pyroptosis of human spermatogonial stem cells via GBP4 regulationhttps://journals.lww.com/ajandrology/fulltext/9900/nlrp3_activation_by_lipopolysaccharide__lps_.372.aspx
Keywords: GBP4; human spermatogonial stem cells; male infertility; NLRP3; pyroptosis]]>
Jin, Wen-Cong1; Zhang, Dong1; Cui, Ying-Hong1; Du, Li1; He, Zuping1,2![CDATE[Received: 29 March 2025; Accepted: 09 July 2025; published online: 16 January 2026]]
Effectiveness of short-term, high-intensive, WHO laboratory standard-based training in sperm morphology assessment: evidence from a national program in Chinahttps://journals.lww.com/ajandrology/fulltext/9900/effectiveness_of_short_term,_high_intensive,_who.419.aspxZhou, Fang*; Guo, Ying*; Wang, Xiao-Wei; Qiu, Shi; Xu, Jian-Feng; Zhao, Hai-Bao; Gu, Yi-Qun; Fu, Long-Long; Lu, Wen-Hong![CDATE[Received: 29 January 2026; Accepted: 03 March 2026; published online: 19 May 2026]]Association of sulfur dioxide exposure with sperm quality in reproductive-aged men: the mediating and moderating roles of essential elements in seminal plasmahttps://journals.lww.com/ajandrology/fulltext/9900/association_of_sulfur_dioxide_exposure_with_sperm.381.aspxYin, Tao1,2,3,*; Zhou, Xin-Yu1,2,3,*; Li, Xiao-Qing1,4; Dong, Rui2; Li, Qian2; Yue, Xin-Yu1,2,3; Zhang, Dong-Yang2; Su, Xun1,2,3; Tao, Fang-Biao2; Luo, Gui-Ying1,4; Ji, Dong-Mei1,2,3; Liang, Chun-Mei1,2,3; Cao, Yun-Xia1,2,3![CDATE[Received: 29 April 2025; Accepted: 16 September 2025; published online: 30 January 2026]]Proteomic insights into azoospermia: protein differences in testicular tissue between non-obstructive and obstructive azoospermia patientshttps://journals.lww.com/ajandrology/fulltext/9900/proteomic_insights_into_azoospermia__protein.423.aspx
Keywords: biomarkers; differentially expressed proteins; non-obstructive azoospermia; obstructive azoospermia; proteomics]]>
Wang, Zhi1,2,3,*; Li, Xiao-Dong4,5,*; Shao, Wei-Min6; Zheng, Dong-Xuan7; Xiang, Xiao-Qiang3; An, Heng-Qing4,5; Yang, Jian-Hua1,2![CDATE[Received: 29 April 2025; Accepted: 05 February 2026; published online: 29 May 2026]]
Preliminary observations on phenotypic differences between complete and partial globozoospermiahttps://journals.lww.com/ajandrology/fulltext/9900/preliminary_observations_on_phenotypic_differences.409.aspxChen, Gang-Xin1,*; Xu, Hui-Lin1,2,*; Yang, Lei1; Zheng, Bei-Hong1,3; Sun, Yan1,2![CDATE[Received: 28 September 2025; Accepted: 26 January 2026; published online: 17 April 2026]]The therapeutic effect and mechanism of low-intensity pulsed ultrasound for erectile dysfunctionhttps://journals.lww.com/ajandrology/fulltext/9900/the_therapeutic_effect_and_mechanism_of.401.aspxWu, Mei-Li-Yang1; Xu, Wen-Chao2; Wang, Tao2; Liu, Ji-Hong2; Li, Hao2![CDATE[Received: 28 May 2025; Accepted: 16 December 2025; published online: 13 March 2026]]A novel hemizygous missense variant in the BEND2 gene is associated with nonobstructive azoospermiahttps://journals.lww.com/ajandrology/fulltext/9900/a_novel_hemizygous_missense_variant_in_the_bend2.416.aspx
Keywords: BEND2; genetic variant; meiotic arrest; nonobstructive azoospermia; whole-exome sequencing]]>
Luo, Chun-Hai1,*; Yu, Zi-Qi1,*; Wang, Hong-Yi1; Zhou, Hao2; Wu, Yun-Hao1; Shao, Li-Fu1; Liu, Han-Chao1; Zhan, Jun-Feng1; Xie, Chong1; Ke, Sheng-Wei1; Zhang, Bei-Bei1![CDATE[Received: 27 July 2025; Accepted: 09 January 2026; published online: 12 May 2026]]
Icariin targets PDE5A to regulate viability, DNA synthesis and DNA damage of spermatogonial stem cells and improves reproductive capacityhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12279358/
Keywords: DNA damage, Icariin, PDE5A, proliferation, spermatogonial stem cells]]>
Tian-Long Liao1,2,*, Cai-Mei He1,*, Di Xiao1, Zhi-Rong Zhang1, Zuping He1, Xiao-Ping Yang1![CDATE[Received: 27 February 2024; Accepted: 17 October 2024; published online: 07 January 2025]]
Inflammation, immune cells, signaling mechanisms, and diseases of male reproductive systemhttps://journals.lww.com/ajandrology/fulltext/9900/inflammation,_immune_cells,_signaling_mechanisms,.411.aspx
Keywords: immune cells; inflammation; inflammatory factors; male infertility; signaling transduction pathways]]>
Zhu, Yan-Na1,*; Jin, Wen-Cong1,*; Zhang, Dong1; He, Zuping1,2![CDATE[Received: 26 May 2025; Accepted: 07 January 2026; published online: 24 April 2026]]
MicroRNAs profiles in seminal plasma: a bioinformatic insight into pathways and gene networks involved in non-obstructive azoospermia (NOA)https://journals.lww.com/ajandrology/fulltext/9900/micrornas_profiles_in_seminal_plasma__a.363.aspx
Keywords: azoospermia; biopsy; infertility]]>
Maldonado, Gabriel1; Marconi, Marcelo2; Moreno, Ricardo D1![CDATE[Received: 26 January 2025; Accepted: 19 June 2025; published online: 13 January 2026]]
Differences in adipose-derived stem cells from rats with various health statuses and their effects in diabetic rats with erectile dysfunctionhttps://journals.lww.com/ajandrology/fulltext/9900/differences_in_adipose_derived_stem_cells_from.390.aspx
Keywords: adipose-derived stem cells; diabetic; erectile dysfunction]]>
Liu, Guo-Chao1,*; Zheng, Lei1,*; Wei, Le-Tian1; Liu, Zhi-Yu1; Jiang, Hui2; Jiang, Tao1![CDATE[Received: 26 February 2025; Accepted: 29 October 2025; published online: 17 February 2026]]
Correlation between weight loss and testosterone restoration after sleeve gastrectomy in patients with biochemical male obesity-associated secondary hypogonadismhttps://journals.lww.com/ajandrology/fulltext/9900/correlation_between_weight_loss_and_testosterone.387.aspxZhao, Yi-An*; Cao, Chong*; Chu, Yu-Xiao; Hua, Rong; Xu, Bo; Shen, Qi-Wei; Fu, Xiao-Jian; Yao, Qi-Yuan; Shao, Yi-Kai![CDATE[Received: 25 June 2025; Accepted: 30 October 2025; published online: 10 February 2026]]Inflammatory bowel disease (ulcerative colitis type) severity shows inverse correlation with semen parameters and testosterone levelshttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10919423/?report=classicDarmadi Darmadi1,*, Cennikon Pakpahan2,3,*, Rajender Singh4, Ankur Saharan5, Wanly Syahrizal Pasaribu2, Hermansyah Hermansyah2, Andri Rezano2,6![CDATE[Received: 25 July 2023; Accepted: 05 September 2023; published online: 07 November 2023]]Combined effects of urine exposure and cryopreservation on sperm quality: an in vitro study of retrograde ejaculationhttps://journals.lww.com/ajandrology/fulltext/9900/combined_effects_of_urine_exposure_and.420.aspx
Keywords: DNA fragmentation; DNA methylation; retrograde ejaculation; spermatozoa]]>
Liang, Ming-Jie1,2; Li, Qian-Yi1,2; Pang, Tao1,3; Liu, Huang4; Wang, Qi-Ling1,2; Zhou, Ying-Yi1,2; Zhuang, Jia-Ming1,2; Zhang, Ying1,2![CDATE[Received: 21 November 2025; Accepted: 03 March 2026; published online: 22 May 2026]]
A homozygous splicing mutation in CCDC39 caused multiple morphological abnormalities of the flagella in an infertile man with primary ciliary dyskinesiahttps://journals.lww.com/ajandrology/fulltext/9900/a_homozygous_splicing_mutation_in_ccdc39_caused.424.aspxG, was identified in a patient of a consanguineous Chinese family presenting a typical PCD phenotype. Quantitative real-time polymerase chain reaction (qPCR) and immunofluorescence demonstrated a significant reduction in CCDC39 mRNA levels and loss of the expression of CCDC39 and other axoneme dynein proteins, respectively. Diff-Quik staining and semen analysis from the patient revealed severely reduced sperm motility, in addition to a pronounced MMAF phenotype. Severe axonemal disorganization and ultrastructural defects were consistent with the PCD phenotype in the patient, further suggesting that CCDC39 deficiency is linked to both infertility and systemic ciliary dysfunction. After intracytoplasmic sperm injection (ICSI) treatment, the CCDC39-deficient patient achieved a successful pregnancy. Overall, our findings clearly indicate that the c.1528-2A>G mutation in CCDC39 is associated with the pathogenesis of both MMAF and PCD, thereby advancing genetic diagnosis, treatment, and prognosis related to in vitro fertilization (IVF) outcomes associated with the MMAF phenotype in PCD patients.

Keywords: CCDC39; male infertility; multiple morphological anomalies of the flagella; primary ciliary dyskinesia; sperm flagella]]>
Tao, Wen1,2,*; Li, Ming3,*; Uddin, Islam2; Yan, Di2; Jiang, Xiao-Hua2; Bai, Shun2![CDATE[Received: 21 June 2025; Accepted: 05 January 2026; published online: 29 May 2026]]
Testicular sperm aspiration enhances fertilization rates in MMAF patients undergoing ICSI: a retrospective cohort studyhttps://journals.lww.com/ajandrology/fulltext/9900/testicular_sperm_aspiration_enhances_fertilization.418.aspxPeng, Lei-Xi1,*; Fu, Long-Long2,*; Li, Jin-Hong1; Qin, Lang1; Qiao, Xiao-Yong1; Bai, Yu1; Lu, Wen-Hong2; Yang, Yi-Hong1![CDATE[Received: 21 July 2025; Accepted: 22 January 2026; published online: 15 May 2026]]Biallelic variants in TBC1D8 are potentially associated with male infertility due to non-obstructive azoospermia or cryptozoospermiahttps://journals.lww.com/ajandrology/fulltext/9900/biallelic_variants_in_tbc1d8_are_potentially.376.aspxT (p.A297V) and c.2461G>A (p.V821I), and patient P2 with cryptozoospermia carried c.854C>T (p.P285L) and c.1912G>A (p.D638N). Bioinformatic analyses predicted that all identified TBC1D8 variants were likely pathogenic. Compared with a normal control, patient P1 showed reduced expression of TBC1D8 in testicular tissue. Subsequently, hematoxylin-eosin staining and immunofluorescence analysis of testicular sections showed defective acrosome formation and the absence of elongated spermatids in patient P1, resulting from abnormal autophagy. Additionally, intracytoplasmic sperm injection treatment was beneficial for patient P2 with cryptozoospermia. In conclusion, our results suggest that TBC1D8 is a potentially novel candidate gene for male infertility associated with NOA or cryptozoospermia in humans.

Keywords: cryptozoospermia; male infertility; non-obstructive azoospermia; spermatogenesis; TBC1D8]]>
Sang, Yi-Lin1,*; Peng, Yao2,3,*; Tu, Chao-Feng4,5; Lin, Ge2,3,4,5; Lu, Guang-Xiu2,3,4,5; Du, Juan2,4,5; Wang, Fu-Yan1; Tan, Yue-Qiu2,3,4,5; Liu, Lv-Jun6; He, Wen-Bin2,3,5![CDATE[Received: 20 February 2025; Accepted: 09 September 2025; published online: 20 January 2026]]
Rho-kinase inhibition reduces DNA fragmentation in human sperm cryopreservationhttps://journals.lww.com/ajandrology/fulltext/9900/rho_kinase_inhibition_reduces_dna_fragmentation_in.414.aspx
Keywords: cryopreservation; DNA fragmentation; sperm; TUNEL assay]]>
Limvorapitux, Pawan1; Thanaboonyawat, Isarin2; Prechapanich, Japarath2; Laokirkkiat, Pitak2; Choavaratana, Roungsin2; Petyim, Somsin2,3![CDATE[Received: 20 August 2025; Accpeted: 17 November 2025; published online: 28 April 2026]]
The causal effect of family history of cardiovascular disease on erectile dysfunction: a randomized clinical study and Mendelian randomization studyhttps://journals.lww.com/ajandrology/fulltext/9900/the_causal_effect_of_family_history_of.404.aspx
Keywords: cardiovascular disease; erectile dysfunction; family history; genetic susceptibility; Mendelian randomization]]>
Li, Dong-Jie1; Xiang, Bo-Yu1; Li, Yong2; Zhang, Chi-Teng2; Liu, Li2; Li, Xiu-Cheng2![CDATE[Received: 20 April 2025; Accepted: 12 November 2025; published online: 24 March 2026]]
Psychological and sexual associations of azoospermia in men: a cross-sectional pre-biopsy studyhttps://journals.lww.com/ajandrology/fulltext/9900/psychological_and_sexual_associations_of.413.aspxYildirim Kopuk, Sule1; Kulaksiz, Deniz1; Yilmaz, Mehmet2; Balaban, Muhsin3; Ayribas, Basar4; Garayev, Asgar5; Degirmentepe, Recep Burak6; Ozgur, Mehmet Ozay7; Ozcan, Eda8; Guzel, Ahmet9; Baglar, Ismail10; Toprak, Tuncay11![CDATE[Received: 19 August 2025; Accepted: 18 December 2025; published online: 28 April 2026]]A narrative review on the role of autophagy in male infertility-associated sperm abnormalitieshttps://journals.lww.com/ajandrology/fulltext/9900/a_narrative_review_on_the_role_of_autophagy_in.379.aspx
Keywords: autophagy; male infertility; spermatogenesis; sperm abnormality]]>
Jin, Yi-Han1,2,*; Gao, Da-Wei1,*; Li, Chu-Yu1,3; Sun, Da-Lin4; Mo, Hui1; Jin, Bao-Fang4![CDATE[Received: 18 May 2025; Accepted: 13 October 2025; published online: 20 January 2026]]
Comparative sperm proteomics in IVF patients with differential fertilization rates identifies FAM205A as a novel biomarker for male infertilityhttps://journals.lww.com/ajandrology/fulltext/9900/comparative_sperm_proteomics_in_ivf_patients_with.417.aspxZhang, Peng1,2,3; Li, He-Mei1,2; Lu, Sai1,2; Fan, Li-Qing4,5; Qian, Hui1,2; Yin, Jiu1,2![CDATE[Received: 18 July 2025; Accepted: 03 November 2025; published online: 12 May 2026]]Effects and mechanism of low-intensity pulsed ultrasounds on testicular steroidogenesis in ratshttps://journals.lww.com/ajandrology/fulltext/9900/effects_and_mechanism_of_low_intensity_pulsed.408.aspx
Keywords: hypogonadism; Leydig cells; low-intensity pulsed ultrasound; regenerative therapy; testosterone]]>
Meng, Xianghu1,2; Zhou, Feng1,3; Wiborg, Majken H#248;jrup1,4; Qin, Caipeng1,5; Banie, Lia1; Wiriyabanditkul, Weerayut1,6; Wang, Guifang1; Lin, Guiting1; Lue, Tom F1![CDATE[Received: 18 August 2025; Accepted: 12 January 2026; published online: 17 April 2026]]
Predictive factors shaping fertility potential and reproductive outcomes in men with Klinefelter syndromehttps://journals.lww.com/ajandrology/fulltext/9900/predictive_factors_shaping_fertility_potential_and.393.aspx
Keywords: Klinefelter syndrome; sperm retrieval rate; testicular sperm extraction
]]>
Atar, Itai1; Barda, Shimi1,2; Kalma, Yael1; Kleiman, Sandra E1,3; Azem, Foad1,3; Hauser, Ron3; Dekalo, Snir3,4; Weizman, Noga Fuchs1,3![CDATE[Received: 17 June 2025; Accepted: 29 September 2025; published online: 27 February 2026 ]]
Male testosterone synthesis disorders: oxidative stress pathways, regulatory mechanisms, potential of antioxidant therapy, and botanical medicine prospectshttps://journals.lww.com/ajandrology/fulltext/9900/male_testosterone_synthesis_disorders__oxidative.406.aspx
Keywords: antioxidant; botanical medicine; Leydig cells; male disease; oxidative stress; testosterone synthesis
]]>
Wu, Hui1,*; Jian, Min-Tao1,*; Ning, Gang1; Li, Bo-Nan2; Peng, A-Jian1; Wang, Hao-Yu1; Tang, Xue3; Zhou, Xing1![CDATE[Received: 17 July 2025; Accepted: 17 December 2025; published online: 03 April 2026]]
Small RNA profile alterations as a potential mechanism for sperm quality improvement following varicocelectomyhttps://journals.lww.com/ajandrology/fulltext/9900/small_rna_profile_alterations_as_a_potential.374.aspxKeywords: epigenetic; male infertility; miRNA; sperm quality; varicocele]]>Li, Jian-Hui1,2,3; Li, Jian-Ying3; Tang, Jia-Nan2; Wang, Xue-Mei2; Zhang, Gao-Yue3; Huang, Hao-Guang2,3; Wang, Xin2,3; Chen, Guo-Wu4; Liang, Guo-Qing5; Hu, Jian-Lin5; Zhang, Tian-Cheng2; Zhang, Xu2; Shi, Hui-Juan2; Hua, Min-Min2; Zhang, Jin1![CDATE[Received: 17 February 2025; Accepted: 08 August 2025; published online: 16 January 2026]]Multidimensional explanations and future perspectives on the limited efficacy of immunotherapy in prostate cancerhttps://journals.lww.com/ajandrology/fulltext/9900/multidimensional_explanations_and_future.386.aspx
Keywords: immune checkpoint inhibitors; immunotherapy; prostate cancer; therapeutic cancer vaccines; tumor microenvironment]]>
Fan, Shan-Shan1; Chen, Yi-Min2,3; Chen, Wen-Da2,3; Sun, Zheng-Hua1; Yin, Jian1; Xie, Mei1; Wu, Pu1,2,3![CDATE[Received: 16 June 2025; Accepted: 21 October 2025; published online: 10 February 2026]]
177Lu-PSMA for prostate cancer: progress, challenges and future perspectiveshttps://journals.lww.com/ajandrology/fulltext/9900/177lu_psma_for_prostate_cancer__progress,.388.aspx
Keywords: 177Lu-PSMA; biomarkers; clinical trials; combination therapy; precision medicine; prostate cancer; radioligand therapy;
radiopharmaceuticals]]>
Xi, Zhen*; Ji, Shi-Yu*; Zhang, Yu; Sun, Ming-Hui; Jia, Gao-Zhen; Jiang, Qi![CDATE[Received: 16 June 2025; Accepted: 19 November 2025; published online: 13 February 2026]]
Surgical treatment of Peyronie*s disease by plaque incision and buccal mucosa graft: a systematic review and meta-analysishttps://journals.lww.com/ajandrology/fulltext/9900/surgical_treatment_of_peyronie_s_disease_by_plaque.391.aspx
Keywords: buccal mucosa; graft; Peyronie*s disease; plaque; systematic review]]>
Badr, Hattan1,2; Bettocchi, Carlo3; Alsalem, Abdulrahman1,4; Ricapito, Anna3; Rubino, Matteo3; Buffi, Nicol辰5,6; Gobbo, Andrea1; Ralph, David7; Sedigh, Omid1,6![CDATE[Received: 15 September 2024; Accepted: 12 May 2025; published online: 24 February 2026]]
Real-world effectiveness and safety of radium-223 therapy in castration-resistant prostate cancer with bone metastaseshttps://journals.lww.com/ajandrology/fulltext/9900/real_world_effectiveness_and_safety_of_radium_223.397.aspx3 was an independent protective factor of OS (hazard ratio [HR] = 0.443, 95% CI: 0.234每0.837; P = 0.012) after adjusting for age, combination therapy, and previous chemotherapy. For those administered all six injections of Ra-223, no patients had a pain score of 4 and only 4.2% of patients showed a pain score of 3. In total, 62.5% of patients had almost no pain (0 point). Median alkaline phosphatase showed a downward trend during the six-injection treatment period. The most common adverse event was anemia (30.1%), followed by thrombocytopenia (15.1%), nausea (9.7%), weakness (8.6%), and decreased white blood cells (7.5%). This real-world study strongly suggests that Ra-223 has good effectiveness and tolerability in Chinese patients with mCRPC and bone metastases.

Keywords: bone metastasis; castration-resistant prostate cancer; radium 223; real-world study; treatment effect]]>
Wang, Hong-Kai1,2,3,*; Hang, Zhen1,2,3,*; Liu, Chang2,4; Dai, Bo1,2,3; Zhu, Yao1,2,3; Qin, Xiao-Jian1,2,3; Lin, Guo-Wen1,2,3; Deng, Yan-Bo5; Jiang, He-Xun5; Wang, Ya5; Song, Shao-Li2,4; Ye, Ding-Wei1,2,3![CDATE[Received: 15 May 2025; Accepted: 16 December 2025; published online: 03 March 2026]]
Extraperitoneal single-port robot-assisted radical prostatectomy using da Vinci Xi platform: learning curve and outcome analysishttps://journals.lww.com/ajandrology/fulltext/9900/extraperitoneal_single_port_robot_assisted_radical.373.aspx155 cases). Across phases, operative time decreased by 19.5% (from 174 min to 140 min), estimated blood loss decreased by 40.9% (from 115 ml to 68 ml), and positive surgical margin rate decreased by 61.1% (from 35.2% to 13.7%). At 12 months, 98.0% of the patients achieved continence, and 5.0% experienced biochemical recurrence. Minor complications occurred in 8.5% of the cases, with no severe events reported. Despite its technical challenges and steep learning curve, the extraperitoneal single-port robotic prostatectomy using the da Vinci Xi platform was observed to be safe, feasible, and reproducible, yielding favorable perioperative, functional, and oncological outcomes, even during the initial phase of skill acquisition.

Keywords: learning curve; operative time; prostatic neoplasms; prostatectomy; robotic surgical procedures]]>
Chen, Li-Chen1,2,3,4,*; Wang, Yan1,2,3,4,*; Chen, Xing-Lin1,2,3,4; Tan, Ming-Yue1,2,3,4; Ju, Guan-Qun1,2,3,4; Xu, Dong-Liang1,2,3,4![CDATE[Received: 15 March 2025; Accepted: 25 June 2025; published online: 16 January 2026]]
Association of Ureaplasma urealyticum with lifestyle factors and semen parameters: results from a cross-sectional study in 2668 maleshttps://journals.lww.com/ajandrology/fulltext/9900/association_of_ureaplasma_urealyticum_with.385.aspx2 times per week) were significantly higher in the Ureaplasma urealyticum-positive group than those in the Ureaplasma urealyticum-negative group. After adjustment for potential confounders, smoking (odds ratio [OR] = 1.23, 95% confidence interval [CI]: 1.02每1.49, P = 0.03) and sexual frequency (more than twice per week; OR = 1.41, 95% CI: 1.04每1.91, P = 0.03) remained associated with Ureaplasma urealyticum infection. Regarding semen parameters, ejaculate volume was significantly lower in the Ureaplasma urealyticum-positive group (P = 0.002); however, the prevalence of abnormal semen quality did not differ between the two groups. Logistic regression and restricted cubic spline analysis revealed no significant associations between poor semen quality and Ureaplasma urealyticum infection. In conclusion, Ureaplasma urealyticum infection was associated with certain lifestyle factors but not with semen quality. Further research is required to elucidate the underlying mechanisms and to evaluate potential interventions.

Keywords: lifestyle factors; semen parameters; Ureaplasma urealyticum; smoking; sex frequency]]>
Dai, Xiu-Huan*; Jiang, Xiao-Hua*; Zong, Lu; Tao, Yuan-Yuan; Jin, Qi; Tang, Wen-Juan; Wu, Li-Min; Xu, Bo; Bai, Shun![CDATE[Received: 15 April 2025; Accepted: 20 October 2025; published online: 10 February 2026]]
Triclocarban impacts human sperm motility by inhibiting glycolysis and oxidative phosphorylationhttps://journals.lww.com/ajandrology/fulltext/2025/11000/triclocarban_impacts_human_sperm_motility_by.8.aspx
Keywords: ATP; energy metabolism; human sperm; motility; triclocarban]]>
Fu, Long-Long1,*; Wang, Wei-Zhou2,*; Feng, Yan3; Chen, Fu2; Liu, Bin2; Huang, Liang3; Zhang, Lin-Yuan4,5; Chen, Lei2![CDATE[Received: 14 October 2024; Accepted: 08 May 2025; published online: 26 September 2025]]
C-phycocyanin protects against obesity-associated type 2 diabetes-induced male fertility dysfunction via key enzyme regulationhttps://journals.lww.com/ajandrology/fulltext/9900/c_phycocyanin_protects_against_obesity_associated.392.aspx
Keywords: antioxidant; C-phycocyanin; enzyme; inflammation; obesity; sperm]]>
AlRashidi, Aljazi Abdullah1; Rajeh, Sahar Y1; Hamden, Khaled2,3![CDATE[Received: 13 September 2025; Accepted: 26 November 2025; published online: 24 February 2026]]
Gestational sleep deprivation-induced changes in serum hormone concentrations and testicular oxidative stress affect spermatogenesis in postpubertal male offspring of micehttps://journals.lww.com/ajandrology/fulltext/9900/gestational_sleep_deprivation_induced_changes_in.378.aspxZhang, Xin-Yang1,*; Wang, Kai1,*; Li, Han1; Cui, Qian-Qian1; Li, Ying-Jun1,2,3; Zhao, Dan-He1,4; Bai, Tao5; Wang, Li1,2,3![CDATE[Received: 13 May 2025; Accepted: 26 September 2025; published online: 20 January 2026]]Human pyriform sperm heads in infertile men and assisted reproductive technology outcomes: a retrospective cohort study based on propensity score matchinghttps://journals.lww.com/ajandrology/fulltext/9900/human_pyriform_sperm_heads_in_infertile_men_and.395.aspx
Keywords: assisted reproductive technology outcomes; propensity score matching; pyriform sperm; semen parameters; sperm function
]]>
Jia, Ye-Lin1; Yang, Ting-Ting1; Cheng, Qing-Yuan2; Wu, Ying-Bi2; Zheng, Yan2; Yu, Lin1; Li, Fu-Ping3![CDATE[Received: 12 February 2025; Accepted: 11 October 2025; published online: 03 March 2026]]
Prevalence of semen abnormalities and the impact of genital pathogens on male infertility: a retrospective analysis of 131 183 patientshttps://journals.lww.com/ajandrology/fulltext/9900/prevalence_of_semen_abnormalities_and_the_impact.422.aspx
Keywords: antisperm antibodies; Chlamydia trachomatis; male fertility; Mycoplasma genitalium; Neisseria gonorrhea; semen;
Ureaplasma urealyticum
]]>
Cui, Jing-Jing1,2,3,4,*; Zhong, Wen1,2,3,4,*; Zhang, Yi-Qiang1,2,3,4; Zhang, Xin-Yuan1,2,3,4; Zhang, Hai-Yan3,4,5,6; Li, Shu1,2,3,4; Li, Chun-Li1,2,3,4![CDATE[Received: 10 September 2025; Accepted: 29 January 2026; published online: 26 May 2026]]
Evaluating patient experience with in-person versus virtual vasectomy consultationshttps://journals.lww.com/ajandrology/fulltext/9900/evaluating_patient_experience_with_in_person.402.aspx
Keywords: reproductive; retrospective studies; sterilization; telemedicine; urologic surgical procedures; vasectomy]]>
Paradzinsky, Megan G1; Sharda, Mukul1; Ellison, Jonathan S1; Jin, Yuchen2; Szabo, Aniko2; Sandlow, Jay I1; Dietrich, Peter N1![CDATE[Received: 10 October 2025; Accepted: 26 November 2025; published online: 17 March 2026]]
Predicting the upgrading of the International Society of Urological Pathology Grade Group in nonclinically significant prostate cancer: a multicenter observational studyhttps://journals.lww.com/ajandrology/fulltext/9900/predicting_the_upgrading_of_the_international.412.aspxZhou, Ling1; Li, Shi-Yan1; Wang, Zhang-Yun2; Liu, Yu-Yu1; Chen, Chao3; Yu, Hong4![CDATE[Received: 09 September 2025; Accepted: 09 December 2025; published online: 28 April 2026]]Evaluation of technicians* ability to accurately identify sperm morphology through EQA programs in China: a 5-year nationwide study (2019每2024)https://journals.lww.com/ajandrology/fulltext/9900/evaluation_of_technicians__ability_to_accurately.394.aspx
Keywords: defect identification; external quality assessment; male infertility; sperm morphology; technicians* ability]]>
Zheng, Yan1,2; Wu, Ying-Bi1,2; Yu, Lin1,2; Liu, Yuan1,2; Yuan, Jin-Tao3; Diao, Cheng-Cheng3; Ma, Yi3; Jia, Ye-Lin1,2; Li, Fu-Ping1,2![CDATE[Received: 09 June 2025; Accepted: 11 October 2025; published online: 03 March 2026]]
Novel biallelic FSIP2 variants cause male infertility with multiple morphological abnormalities of sperm flagella in humanshttps://journals.lww.com/ajandrology/fulltext/9900/novel_biallelic_fsip2_variants_cause_male.421.aspxKeywords: fibrous sheaths; FSIP2; male infertility; mitochondrial sheaths; MMAF]]>Yang, Jie1,*; He, Ting-Ting1,2,*; Gu, Ya-Nan1; Xue, Yu1; Chen, Qi1; Yu, Man3; Qiao, Sen1; Shi, Sheng-Jia1![CDATE[Received: 07 November 2025; Accepted: 03 March 2026; published online: 22 May 2026]]Fresh or frozen testicular sperm? Guidance from an etiology-classified retrospective study on ICSI cycles for patients with azoospermiahttps://journals.lww.com/ajandrology/fulltext/9900/fresh_or_frozen_testicular_sperm__guidance_from_an.415.aspx
Keywords: assisted reproductive technology; azoospermia; intracytoplasmic sperm injection; sperm cryopreservation; testicular
sperm extraction]]>
Zhu, Zi-Jue1,*; Ma, Liang-Hong2,3,*; Deng, Cun-Zhong1; Bai, Fu-Rong1; Li, Peng1; Zhou, Li-Na4; Jiang, Shan4; He, Xiao-Jin4; Li, Zheng1,5; Chen, Wei4![CDATE[Received: 06 November 2025; Accepted: 29 January 2026; published online: 01 May 2026]]
Loss-of-function mutations in Ccdc113 cause male infertility in both humans and micehttps://journals.lww.com/ajandrology/fulltext/9900/loss_of_function_mutations_in_ccdc113_cause_male.383.aspxC; p.K301Q and c.404A>C; p.E135A) cosegregated with infertility phenotypes and were associated with defective sperm flagella. Functional analyses demonstrated that these mutations led to less stable CCDC113 protein and severely disrupted axonemal structures in spermatozoa from our three human patients. We generated Ccdc113 knockout mice, which recapitulated the human infertility phenotypes, including abnormal sperm morphology, impaired motility, and defective spermatogenesis. Importantly, one patient achieved successful pregnancy by intracytoplasmic sperm injection, highlighting the translational potential of genetic diagnostics. These findings suggest that CCDC113 is essential for male fertility and contribute to the understanding of the genetic landscape of infertility, offering novel insights into its diagnosis and management.

Keywords: axoneme; CCDC113; male infertility; oligoasthenoteratozoospermia; sperm flagella]]>
Yu, Hong-Tao1,*; Liu, Fu-Lin2,*; Zhang, Xiao-Xiao3; Li, Wei1![CDATE[Received: 05 April 2025; Accepted: 13 October 2025; published online: 06 February 2026]]
Association between body mass index and semen quality in infertile men: a cross-sectional study of 28 167 patientshttps://journals.lww.com/ajandrology/fulltext/9900/association_between_body_mass_index_and_semen.407.aspxCao, Xu1,2; Gao, Lu1,2; Fu, Xiao-Jie1,2; Chen, Jie3; Li, Xia-Yang3; Huang, Yi-Shuai3; Shi, Juan-Zi1; Qu, Peng-Fei1![CDATE[Received: 04 June 2025; Accepted: 29 October 2025; published online: 03 April 2026]]Outcomes following varicocele treatment: a comparative study of microsurgical and angioembolization approacheshttps://journals.lww.com/ajandrology/fulltext/9900/outcomes_following_varicocele_treatment__a.400.aspx
Keywords: angioembolization; infertility; obesity; varicocele; varicocelectomy]]>
Al Homsi, Ammar1; Almidani, Omar1; Youness, Fadi2; Rowaiee, Rashed1; Alabdullah, Ali1; Aljasmi, Omar1; Moussa, Ayman1,3; Siddiqi, Kashif4; Barham, Alaeddin1; Raheem, Omer1![CDATE[Received: 04 June 2025; Accepted: 28 September 2025; published online: 10 March 2026]]
Tektin family in mammalian spermatozoa: structure, function, and diseasehttps://journals.lww.com/ajandrology/fulltext/9900/tektin_family_in_mammalian_spermatozoa__structure,.410.aspx
Keywords: flagellar morphogenesis; male fertility; microtubule inner protein; sperm motility; sperm signaling network; tektin family]]>
Chen, Qi-Jun; Li, Qing-Chao; Nie, Hui![CDATE[Received: 04 January 2026; Accepted: 23 March 2026; published online: 24 April 2026]]
Novel homozygous or compound heterozygous DNAH17 variants lead to male infertility characterized by multiple morphological abnormalities of the sperm flagella and asthenoteratozoospermia in humanshttps://journals.lww.com/ajandrology/fulltext/9900/novel_homozygous_or_compound_heterozygous_dnah17.371.aspx
Keywords: asthenoteratozoospermia; DNAH17; intracytoplasmic sperm injection; male infertility; multiple morphological abnormalities
of the sperm flagella]]>
Yang, Jie1,*; Gu, Ya-Nan1,*; Chen, Qi1; Xue, Yu1; Yu, Man2; Qiao, Sen1; Shi, Sheng-Jia1![CDATE[Received: 02 April 2025; Accepted: 05 August 2025; published online: 16 January 2026]]
Commentary on ※Correlation between weight loss and testosterone restoration after sleeve gastrectomy in patients with biochemical male obesity-associated secondary hypogonadism§https://journals.lww.com/ajandrology/fulltext/9900/commentary_on__correlation_between_weight_loss_and.399.aspxRabijewski, Micha#322;; Wydra, Jakub; Rabijewski, Marcin![CDATE[Received: 01 November 2025; Accepted: 05 December 2025; published online: 06 March 2026]]Current focal therapies for the treatment of low- and intermediate-risk prostate cancerhttps://journals.lww.com/ajandrology/fulltext/2024/26060/current_focal_therapies_for_the_treatment_of_low_.12.aspxMalorgio, Antonio![CDATE[Originally published: October 18, 2024 Received: March 27, 2024 Accepted: July 26, 2024]]The current situation of semen analysis in China, based on a survey of 296 laboratorieshttps://journals.lww.com/ajandrology/fulltext/9900/the_current_situation_of_semen_analysis_in_china,.130.aspxLong-Long Fu 1, Ying Liu 2, Xiao-Wei Wang 1, Fang Zhou 1, Ying Guo 1, Wen-Hong Lu 1, Yi-Qun Gu 1![CDATE[Originally published: October 03, 2023 Received: July 19, 2023 Accepted: August 21, 2023]]Clinical analysis of secondary penile cancer: a case series at a tertiary referral center in Chinahttps://journals.lww.com/ajandrology/Fulltext/9900/Clinical_analysis_of_secondary_penile_cancer__a.105.aspxXiao-Yu Li 1 2 3 4, Chun-Ru Xu 1 2 3 4, Xing Ji 1 2 3 4, Zhen-Peng Zhu 1 2 3 4, Zhen-Ke Guo 1 2 3 4, Tian-Yu Cai 1 2 3 4, Jian Lin 1 2 3 4![CDATE[Originally published: June 09, 2023 Received: January 28, 2023 Accepted: April 18, 2023]]Testicular prostheses 每 impact on quality of life and sexual functionhttps://journals.lww.com/ajandrology/Fulltext/9900/Testicular_prostheses___impact_on_quality_of_life.107.aspx 0.05). However, it can be observed that there are more patients with prostheses presenting normal sexual activity compared to patients without prostheses (74.0% vs 50.0%), and none of them reported severe erectile dysfunction (0 vs 16.7%). Regarding self-esteem, both patients with and without prostheses present very similar average scores with no statistically significant differences. The present study highlights the highest level of satisfaction among patients who received testicular prostheses. Testicular prostheses implantation is a safe procedure that does not hamper sexual function after orchiectomy.

Keywords: orchiectomy; patient satisfaction; quality of life; sexual dysfunction; sexual health; testicular prostheses.]]>
Ana Sofia Ara迆jo 1, Sara Anacleto 1, Ricardo Rodrigues 1, Catarina Tinoco 1, Andreia Cardoso 1, Carlos Oliveira 1, Ricardo Le#227;o 1 2![CDATE[Originally published: July 11, 2023 Received: November 12, 2022 Accepted: May 3, 2023]]
The impact of follicle-stimulating hormone and the sperm concentration on the success of varicocelectomyhttps://journals.lww.com/ajandrology/fulltext/9900/the_impact_of_follicle_stimulating_hormone_and_the.285.aspx#Wang, Li-Hong1,2,*; Zheng, Lei1,2,*; Jiang, Hui3; Jiang, Tao1,2![CDATE[Originally published: February 21, 2025 Received: November 2, 2024 Accepted: December 11, 2024]]Integrated seminal plasma metabolomics and lipidomics profiling highlight distinctive signature of varicocele patients with male infertilityhttps://journals.lww.com/ajandrology/fulltext/9900/integrated_seminal_plasma_metabolomics_and.301.aspx#
Keywords: biomarker; lipidomics; male infertility; metabolomics; varicocele]]>
Zhang, Jing-Di1,*; Li, Xiao-Gang2,*; Wang, Rong-Rong1; Feng, Xin-Xin1; Wang, Si-Yu1; Wang, Hai3; Wang, Yu-Tao3; Li, Hong-Jun3; Li, Yong-Zhe1; Guo, Ye1![CDATE[Originally published: April 08, 2025 Received: July 29, 2024 Accepted: December 9, 2024]]
Phenotypic modulation of corpus cavernosum smooth muscle cells in type 2 diabetic rats is mediated by regulated exosomes secretion via neutral sphingomyelinase-2https://journals.lww.com/ajandrology/fulltext/9900/phenotypic_modulation_of_corpus_cavernosum_smooth.403.aspx
Keywords: corpus cavernosum smooth muscle cells; exosomes; neutral sphingomyelinase-2; phenotypic modulation
]]>
Chen, Feng-Zhi1,2,*; Zhang, Xin-Tao1,2,*; Zeng, Qin-Yu3; Lu, Bing-Xin4; Wang, Li5; Mei, Hong-Bing1,2,6; Wei, An-Yang4![CDATE[Dr. AY Wei (profwei@126.com) or Dr. HB Mei (hbmei68@163.com); published online: 17 March 2026]]
Prognostic value of PTEN in de novo diagnosed metastatic prostate cancerhttps://www.ajandrology.com/preprintarticle.asp?id=317227Jun-Yu Zhang1, Yun-Yi Kong2, Qi-Feng Wang2, Yun-Jie Yang1, Zheng Liu1, Nan Lin1, Ding-Wei Ye1, Bo Dai1![CDATE[28-May-2021]]Relugolix as a promising novel oral GnRH antagonist for prostate cancer treatmenthttps://www.ajandrology.com/preprintarticle.asp?id=301469Jialu Lv1, Jianqing Lin2![CDATE[24-Nov-2020]]Methylated CpG dinucleotides in the 5-汐 reductase 2 gene may explain finasteride resistance in benign prostatic enlargement patientshttps://www.ajandrology.com/preprintarticle.asp?id=301161
Keywords: 5-汐 reductase; benign prostatic enlargement; CpG island; methylated CpG dinucleotides; methylation]]>
Zhe-Min Lin1, Dong-Dong Fan2, Song Jin3, Zhan-Liang Liu1, Yi-Nong Niu1![CDATE[20-Nov-2020]]
Developing a coordinate-based strategy to support cognitive targeted prostate biopsies and correlative spatial-histopathological outcome analysishttps://www.ajandrology.com/preprintarticle.asp?id=301468
Keywords: cognitive targeted prostate biopsies; coordinates; magnetic resonance imaging; prostate cancer]]>
Keiran D Clement1, Lizzy Day2, Helen Rooney1, Matt Neilson3, Fiona Birrell1, Mark Salji1,3,4, Elizabeth Norman1, Ross Clark2, Amit Patel5, John Morrison5, Hing Y Leung1,3,4![CDATE[ 24-Nov-2020]]
Novel strategy using a spiral embedded flap for meatal stenosis after post-penile cancer amputation surgery: a single-center experiencehttps://www.ajandrology.com/preprintarticle.asp?id=343336
Keywords: meatal stenosis; spiral embedded flap; urethroplasty]]>
Ying Wang, Meng Liu, Lu-Jie Song, Ran-Xing Yang, Kai-Le Zhang, San-Bao Jin, Qiang Fu![CDATE[ 15-Apr-2022]]