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Asian Journal of Andrology (2009) 11: 127-130. doi: 10.1038/aja.2008.16; published online 1 December 2008.
Neoadjuvant hormonal deprivation for patients undergoing radical prostatectomy
Xu Gao1,*, Tie Zhou1,*, Yuan-Jie Tang1, Xin Lu1 and Ying-Hao Sun1
1 Department of Urology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China
Correspondence: Dr Ying-Hao Sun, Department of Urology, Changhai Hospital, The Second Military Medical University, 174 Changhai Road, Shanghai 200433, China. Fax: +86-21-6533-8288 E-mail: sunyh@medmail.com.cn
*These authors contributed equally to this work.
Received 28 September 2008; Accepted 2 October 2008; Published online 1 December 2008.
| Abstract |
The purpose of this study is to evaluate the therapeutic effect of radical prostatectomy combined with preoperative neoadjuvant hormonal ablation therapy for prostate cancer (PCa). In this study, a total of 31 patients with local PCa underwent radical prostatectomy; of these, 12 patients underwent preoperative hormonal deprivation with a combination of goserelin and flutamide for a period of 5.6 months. Data regarding clinical characteristics were compared between the neoadjuvant therapy and radical prostatectomy groups. A total of 31 patients received pelvic lymph node clearance, and the rate of positive lymph nodes was 12.9% (4/31). Serum prostate-specific antigen (PSA) was 8.9 ? 1.2 μg L-1 after the neoadjuvant therapy and 0.4 ? 0.3 μg L-1 one month after the radical prostatectomy. There were significant differences in the positive surgical margins, seminal vesicle invasion and lymph node metastasis between the neoadjuvant therapy group (n = 12) and the radical prostatectomy group (n = 19, P < 0.01). The resulsts indicates that preoperative hormonal deprivation induced by goserelin and flutamide can decrease clinical and pathological staging, but assessment of its influence on long-term prognosis requires further study.
Keywords: neoadjuvant therapy, prostate carcinoma, prostatectomy |
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