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Asian Journal of Andrology (2010) 12: 356-362. doi: 10.1038/aja.2010.12; published online 29 March 2010.
Sperm banking for male reproductive preservation: a 6-year retrospective multi-centre study in China
Ping Ping1,*, Wen-Bing Zhu2,*, Xin-Zong Zhang3, Kang-Shou Yao3, Peng Xu4, Yi-Ran Huang1 and Zheng Li1
1 Department of Urology, Shanghai Human Sperm Bank, Shanghai Institute of Andrology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China
2 Institute of Human Reproduction and Stem Cell Engineering, Human Sperm Bank, Central South University, Changsha 410078, China
3 Zhejiang Institute of Planned Parenthood Research & Zhejiang Human Sperm Bank, Hangzhou 310012, China
4 Jinghua Hospital, Shenyang East Group, Shenyang Reproductive Medicine Centre, Shenyang 110005, China
Correspondence: Dr Zheng Li, Department of Urology, Shanghai Human Sperm Bank, Shanghai Institute of Andrology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China. Fax: +86-21-6373-2926 E-mail: doc.zheng.li@gmail.com; Dr Peng Xu, Jinghua Hospital, Shenyang East Group, Shenyang Reproductive Medicine Centre, Shenyang 110005, China. Fax: +86-24-2338-3522 E-mail: xupeng264328578@yahoo.com.cn
* These two authors contributed equally to this work.
Received 26 August 2009; Revised 14 November 2009; Accepted 4 February 2010; Published online 29 March 2010.
| Abstract |
Sperm banking can preserve male fertility effectively, but the current conditions of sperm cryopreservation in China have not been investigated. This retrospective investigation was based on data collected at multiple centres in China from January 2003 to December 2008. The collected data included urogenital history, indication for cryopreservation, semen parameters, use rate, type of assisted reproductive technique (ART) treatment and pregnancy outcome. The study population included 1 548 males who had banked their semen during the study period at one of the clinics indicated above. Approximately 1.9% (30/1 548) of the cryopreserved semen samples were collected from cancer patients; about 88.8% (1 374/1 548) of the patients had banked their semen for ART and 8.6% (134/1 548) had a male infertility disease (such as anejaculation, severe oligozoospermia and obstructive azoospermia). The total use rate of cryopreserved semen was 22.7% (352/1 548), with 119 live births. The cancer group use rate was 6.7% (2/30), with one live birth by intracytoplasmic single sperm injection (ICSI). The ART group use rate was 23.2% (319/1 374), with 106 live births. The reproductive disease group use rate was 23.1% (31/134), with 12 live births. The semen parameters in each category varied; the cancer patient and infertility disease groups had poor semen quality. In vitro fertilization (IVF) and ICSI were the most common ART treatments for cryopreserved sperm. Semen cryopreservation as a salvage method is effective, but in many conditions it is underutilized, especially in cancer patients. Lack of awareness, urgency of cancer treatment and financial constraints are the main causes of the low access rate. The concept of fertility preservation should be popularized to make better use of this medical service in China.
Keywords: cancer; cryopreservation; infertility; sperm |
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