|
Asian Journal of Andrology (2010) 12: 400-404. doi: 10.1038/aja.2009.90; published online 22 March 2010.
Relationship between insulin resistance, obesity and serum prostate-specific antigen levels in healthy men
June Hyun Han1, Yong Taec Lee1, Kyung Won Kwak1, Seung Hyun Ahn1, In Ho Chang2, Soon Chul Myung2, Seung Young Oh3, Yong-Seong Lee4, Wonyong Kim5, Young-Woo Jin6, Tae-In Choi6 and Sook Hee Sung6
1 Department of Urology, KEPCO Medical Foundation Hanil General Hospital, Seoul 132-703, Korea
2 Department of Urology, Chung-Ang University Hospital, Seoul 140-757, Korea
3 Department of Urology, Hyundae General Hospital, Namyangju 472-865, Korea
4 Department of Urology, Hallym University Hangang Sacred Heart Hospital, Seoul 150-719, Korea
5 Department of Microbiology, College of Medicine, Chung-Ang University, Seoul 156-756, Korea
6 Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., LTD, Seoul 132-703, Korea
Correspondence: Dr Soon Chul Myung, Department of Urology, Chung-Ang University Hospital, 224-1, Heukseok Dong Dongjak Ku, Seoul 140-757, Korea. Fax: +82-2-6294-1406 E-mail: uromyung@cau.ac.kr
Received 3 August 2009; Revised 9 October 2009; Accepted 15 December 2009; Published online 22 March 2010.
| Abstract |
The purpose of this study was to determine the relationship between insulin resistance, obesity and serum prostate-specific antigen (PSA) levels in healthy men with serum PSA level below 4 ng mL−1. The men included in the study cohort were 11 827 healthy male employees of the Korea Hydro and Nuclear Power Co., LTD who had undergone medical checkups including fasting glucose, fasting insulin and serum PSA between January 2003 and December 2008. Insulin resistance was calculated by homeostasis model assessment (HOMA [fasting glucose × fasting insulin]/22.5) and quantitative insulin sensitivity check index (QUICKI; 1/[log (fasting insulin) + log (fasting glucose)]). Age-adjusted body mass index (BMI) was significantly increased according to increasing quartile of insulin resistance as determined by HOMA and QUICKI, respectively, in analysis of variance (ANOVA) test and Duncan's multiple comparison test (P < 0.001), but age-adjusted serum PSA concentration was significantly decreased according to increasing quartile of insulin resistance as determined by HOMA and QUICKI (P < 0.001). Age, BMI, insulin resistance by HOMA or QUICKI were significantly independent variables to serum PSA level in a multivariate linear regression analysis (P < 0.001). Insulin resistance was a significant independent variable to serum PSA level along with BMI. Insulin resistance and BMI were negatively correlated with serum PSA level in healthy men. Insulin resistance was positively correlated with BMI.
Keywords: body mass index; insulin resistance; metabolic syndrome X; obesity; prostate-specific antigen |
|
