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Asian Journal of Andrology (2010) 12: 509-518. doi: 10.1038/aja.2010.17; published online 5 April 2010.
Human prostate cancer heterotransplants: a review on this experimental model
Lluis A. Lopez-Barcons1,2
1 Stanley S. Scott Cancer Center, Louisiana State University, Health Sciences Center, New Orleans, LA 70112, USA
2 2Present address: Department of Radiation Oncology, Emory University School of Medicine and Winship Cancer Institute, 1365C Clifton Road, Atlanta, GA 30322, USA. Fax: +1-404-778-1909 E-mail: llopezb@emory.edu
Correspondence: Dr Lluis A Lopez-Barcons, Stanley S. Scott Cancer Center, Louisiana State University, Health Sciences Center, 533 Bolivar Street, New Orleans, LA 70112, USA. Fax: +1-504-568-6888 E-mail: lalb93@gmail.com
Received 18 November 2009; Revised 13 January 2010; Accepted 16 January 2010; Published online 5 April 2010.
| Abstract |
A common model used for preclinical research was in vitro human tumor cell culture. An alternative model was the direct implantation of a unique patient's tumor biopsy specimens into immunodeficient host mice. Published data from PubMed (http://www.ncbi.nlm.nih.gov) and Current Contents Connect databases (http://thomsonreuters.com/products_services/science/science_products/a-z/current_contents_connect) were reviewed. Prostate cancer (PCa) heterotransplantation was evaluated using histopathology, morphology, cell differentiation, DNA content, tumor marker expression, metastases, tumor kinetics, tumor take rate and tumor vasculature in the first tumor heterotransplant. The heterotransplanted tumor retained the biological properties of the original tumor, such as morphology, degree of differentiation, pathology, secretory activity, expression of tumor markers and human vasculature. Human PCa heterotransplants have considerable experimental advantages over cell culture following xenotransplantation.
Keywords: cancer; experimental model; heterotransplant; nude mice; prostate; xenotransplant |
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