The Asia Pacific
Society for the Study of the Aging Male (APSSAM) Dato
Hui Meng TAN
Secretary-General, APSSAM
The Asia Pacific Society for Study
of the Aging Male was formed at the successful conclusion of the
1st Asian ISSAM Meeting in Kuala Lumpur in March 2001. Its inauguration
was the result of the tremendous interest generated from this Asian
Meeting and from the two precedent World Congresses on The Aging
Male organized by the International Society for the Study of the
Aging Male (ISSAM).
APSSAM derived its strength from
highly acclaimed opinion leaders from 15 Asia-Pacific countries
who are established experts in their respective fields and who have
special interest in issues relevant to the Aging Male & Men's
Health. APSSAM Council Members are already well recognized opinion
leaders in Male Sexual Dysfunction, and the majority of them also
serve on Erectile Dysfunction (ED) Councils in their respective
countries. These ED councils were the results of widespread publicity
and rapidly expanding field of ED following the launch of sildenafil.
In many countries, ED, Men's Health and Male Aging are recognized
to be very closely interrelated issues, and they are well integrated
into continuing medical education programmes and public health promotions.
Countries in the Asia-Pacific region,
occupying one-third of the world's land area and sustaining 58 %
of the world population, have very diverse ethnic, cultural and
religious origins. Generally, these markedly contrasting people
living in equally contrasting climatic condition are aging like
the rest of the world population. The experience of the Western
world in handling and managing aging population, though generally
well tested and established, cannot be fully adopted and rigidly
applied to most Asia- Pacific countries. Asian diets, cultural practices,
family values, quality of life issues differ greatly from those
of the West. Asia-Pacific leaders need to come up with specific
programmes, ideas, researches etc. to be incorporated into
those basic principles and practices of managing the aging male
population which have been fairly well studied by many Western experts.
The Mission of APSSAM is to develop
Asia-Pacific specific programmes to help improve awareness, understanding
and management of problems of Men's Health in general and of the
Aging Male in particular, in order to help men age successfully
and to enhance the overall health and quality of life of men of
all ages. This will be accomplished through the creation and dissemination
of educational and training programmes for medical professionals,
patients and the public. By so doing, APSSAM will strive to be the
'Reference Centre' and the 'Centre of Excellence' for the management
of problems of the Aging Male and Men's Health in the Asia- Pacific
region.
APSSAM objectives are as follows:-
-
To improve the health, status,
longevity and quality of life of the aging male.
-
To promote research and development
in the field of aging in the male.
-
To promote and facilitate the
exchange and dissemination of knowledge and information in the
specialty.
-
To propose, establish, implement
and supply curricula and standards for studies in the field
of the aging male.
-
To promote and organize national
and international conferences and meetings on subjects of study
in the field of aging in the male.
-
To provide educational activities
and dissemination of knowledge on the importance of health in
the aging male to the public at large.
-
To promote and collaborate with
the industries, governments and related non-governmental organizations
in supporting the above objectives.
Inaugural Council of APSSAM for
2001 ~ 2003:
Chairman:
|
Dato
Dr. Hui Meng TAN (Subang Jaya) |
Secretary:
|
Dr.
Clarence CM LEI (Kuching) |
Council
Members: |
Prof.
Arif ADIMOELJA (Surabaya)
Prof. Han-Sun CHIANG (Taipei)
Prof. Young Chan KIM (Kyonggi-do)
Prof. Peter HC LIM (Singapore)
Dr. Sudhakar KRISHNAMURTI (Hyderabad)
Prof. Shao-Zhen QIAN (Shanghai)
Dr. Doddy M.SOEBADI (Surabaya)
Prof. Ji-Chuan ZHU (Beijing) |
Dr. Kew
Kim CHEW (Perth)
Prof. Nobuhisa ISHII (Chiba)
Prof. Apichat KONGKANAND (Bangkok)
Dr.Moh Ismail MOHD TAMBI (Kuala Lumpur)
Dr. Akihiko OKUYAMA (Osaka)
Dr. Jose REYES (Manila)
Dr. Delfin TAN (Manila) |
Executive Committee for
2003 ~ 2005:
President: |
Prof. Han Sun CHIANG (Taipei) |
President-Elect: |
Prof. Apichat KONGKANAND (Bangkok) |
Secretary-General: |
Prof. Dato Dr Hui Meng TAN (Subang
Jaya) |
Treasurer: |
Dr. Clarence Chang Moh LEI (Kuching) |
Editor-in-Chief: |
Dr. Kew Kim CHEW (Perth) |
Committee
Members: |
Prof. Arif ADIMOELJA
(Surabaya)
Prof. Narmada P GUPTA (New Delhi)
Prof. Young Chan KIM (Kyonggi-do)
Dr. Sudhakar KRISHNAMURTI (Hyderabad)
Prof. Youngjin LEE (Pochon)
Prof. Akihiko OKUYAMA (Osaka)
Dr. Doddy M SOEBADI (Surabaya) |
Prof. Victor H H GOH (Singapore)
Prof. Nobuhisa ISHII (Chiba) Dr. Mohd
Ismail MOHD TAMBI (Kuala Lumpur)
Dr. Y KUMAMOTO (Sapporo)
Prof. Peter Huat Chye LIM (Singapore)
Dr. Jose REYES (Manila)
Dr. Andrew YIP (Hong Kong) |
Editorial
Population aging and
the aging male
K. K. Chew
There is no mystique
in the phenomenon of population aging. The challenge really is to
fully appreciate its immense and far-reaching impact and consequences.
Advances in various
biotechnological fields and improvement in environment and healthcare
have contributed to a significant decline in mortality rates of
diseases. Effective options in fertility control have made it possible
for couples to delay starting, and to limit the size of, their families,
often in order to give or preserve quality in parenting within their
means. Increasing opportunities in the workforce for women and the
preference of many for career-orientated lifestyles have brought
about changes in family structure and values. Inevitably, increasing
life expectancy and declining fertility lead to population aging.
Not unexpectedly,
an aging population will increase the demand on social, healthcare
and support services, causing public as well as private expenditure
to escalate. Having a greater proportion of aged persons relative
to the working-age population will mean a higher dependency ratio,
decreased labour supply and a reduced tax base. These will compound
the strain on community resources and make a nations
budgetary capacity ultimately
untenable.
Aging may be associated
with a gamut of chronic illnesses, degenerative diseases and debilitating
disabilities. In the aging male, gender-specific medical problems
are prevalent and significant. These include prostatic diseases,
androgen deficiency, erectile dysfunction and other forms of sexual
dysfunction. There may also be gender-related increased vulnerability
in various clinical and non-clinical conditions.
Ironically, the rate
of population aging is gaining even greater acceleration in countries
and regions where resources are less and ability to cope is lower.
In the most socio-economically-disadvantaged groups, both the life
expectancy and healthy life expectancy are lowest while the difference
between these indicators, denoting the period of burden of disease
and disability, remains the greatest.
Population projections
suggest that, by 2025, Indonesia will have a 414 % increase in her
population aged 65 years and older. Likewise, Thailand, India, China
and Bangladesh will experience an increase in excess of 200 %. There
is therefore an urgent need for appropriate action by specific interest
groups and peak organizations such as the Asia Pacific Society for
the Study of the Aging Male (APSSAM).
As shown in the two reports in this
Section, APSSAM was formed in 2001 and has already hosted two successful
conferences on The Aging Male, catering especially to the needs
of the Asia-Pacific region. With the generous provision of these
pages in the Asian Journal of Andrology and with the blessing
of a harmonious and genial relationship with the Asian Society
of Andrology (both considerations being gratefully acknowledged
by APSSAM), it is hoped that the mission and objectives of APSSAM
may be more easily achieved.
Prevalence of hypogonadism in
the aging male and male erectile dysfunction in Asia-Pacific
countries
K. K. Chew
1 Background
Hypogonadism in
aging men and male sexual dysfunction are important gender-specific
conditions which have significant clinical, epidemiological and
socio-economic implications. Data on their respective prevalence
are scarce and sporadic. Yet, it is important that such information
be available, in order that healthcare planners and providers may
allocate appropriate resources for their management and prevention.
A Symposium was therefore
planned for the 2nd Meeting on The Aging Male organized by the Asia
Pacific Society for the Study of the Aging Male (APSSAM) in Taipei
on 6th~9th March 2003, so that members of APSSAM would have the
opportunity of presenting the relevant data pertinent to their respective
countries.
The following APSSAM
members (in alphabetical order) participated in the Symposium: Prof.
A Adimoelja (Surabaya), Dr. KK Chew (Perth), Prof. NP Gupta (New
Delhi), Prof. ST Huang (Taipei), Prof. YC Kim (Kyonggi-do), Prof.
A Kongkanand (Bangkok), Prof. PHC Lim (Singapore), Prof. A Okuyama
(Osaka), Prof. Dato HM Tan (Subang Jaya).
This report contains
a summary of the data from these presentations, the abstracts of
which were published in the Abstract Book of the Meeting. To complement
these, data on the subjects that had previously been presented at
conferences or published in the medical literature are also included
in this report.
2 Prevalence of
Hypogonadism in the Aging Male
The diagnosis of hypogonadism
should only be sustained when biochemically confirmed decreased
plasma testosterone (T) levels are clinically collaborated with
the appropriate symptom-complex. Most of the data presented therefore
referred more to decreased androgen, or, more specifically, decreased
T status, suggesting androgen or T deficiency.
These data and the
legends used are as follows:
T = testosterone
bT = bioavailable testosterone
cfT = calculated free testosterone
SHBG = sex hormone binding glogulin
nSHBG-T = non-SHBG bound testosterone
ADAM = androgen deficiency of the aging male
T levels on blood samples obtained
in a community-based study (n = 927) in Busselton, Australia, were
reported [1]. These are shown in Table 1.
Table 1. Testosterone levels in aging
males: community-based Busselton Study (n = 927)[2].
|
60~69
yrs
|
70
yrs
|
Lower
limit of normal reference range(2.5th centile in men 40
yrs)
|
T
|
4.4%
|
5.1%
|
7.56
nmol/L
|
cfT
|
3.9%
|
4.3%
|
0.162
nmol/L
|
nSHBG-T
|
4.4%
|
4.3%
|
4.28
nmol/L
|
The results of another
Australian study [2] were alluded to which found that 5.7 % of men
(n=1,455) with erectile dysfunction had decreased plasma
T levels (<11 nmol/L).
No prevalence data
were presented for India, Indonesia, Japan and Singapore.
In Korea, an average
of 8.3 % (2.1 % to 21 %) of men (n= 2,722) referred for erectile
dysfunction in 7 studies had plasma T levels less than 10.4 nmol/L
(300 ng/dL).
In a study in Malaysia,
plasma T levels of less than 8 nmol/L were found in 40.7 % of men
(n= 118) aged 50 years~93 years with general urological problems.
St. Louis University ADAM Questionnaire Score was positive in 48.3
%.
3.1 % to 9.8 % of men
in Taiwan region with erectile dysfunction had hypogonadism.
In Thailand,
decreased plasma T levels were reported in 7 % of men aged <60
years and in 70 % of those aged >60 years with sexual dysfunction,
Decreased bT was found in up to 70 % of men aged >60 years.
3 Prevalence of male
erectile dysfunction
In a study on
the prevalence of erectile dysfunction (ED) in Australia involving
1,240 attendees at general medical practices [3], the findings reported
are shown in Table 2.
Table 2. Prevalence
of ED: 1240 attendees at general medical practices (Chew et al.
[4])
Age
groups (yrs)
|
ED
- all grades (%)
|
ED
- all the time (%)
|
40~49
|
13.1
|
2.0
|
50~59
|
33.5
|
8.4
|
60~69
|
51.5
|
21.2
|
70~79
|
69.2
|
44.9
|
80
|
76.2
|
52.4
|
18~91
|
39.4
|
18.6
|
40~69
|
33.9
|
11.9
|
Prevalence and severity
of ED increase with age.
Prevalence and severity
of ED increase with age.
No prevalence data
were presented for India, Indonesia, Japan, Korea and Malaysia.
A survey of 336 patients with sexual dysfunction in Surabaya,
Indonesia, showed that
86.3 % had ED and 13.7 % had premature ejaculation.
Preliminary findings
in a study in Singapore were presented which showed that in men
aged 45 years~70 years prevalence of ED was 72.7 % with 14.1 % reporting
complete ED.
Prevalence of ED in
men aged >40 years is 17.7 % in Taiwan area .
In Thailand, the findings of a study
on the prevalence of ED are shown in Table 3.
Table 3. Prevalence of ED in Thailand.
Age-group
(yrs)
|
Erectile
dysfunction (%)
|
40~49
|
20
|
50~59
|
46
|
60~69
|
73
|
Data on prevalence
of ED which had previously been presented at conferences or published
in medical literature are shown in Table 4.
Table 4. Data presented
at previous conferences or published in journals:
|
Age
(yrs)
|
ED
(%)
|
Complete
ED (%)
|
Australia
|
Chew
et al. (2000) [3]
|
18~91
|
39.4
|
18.6
|
Pinnock
et al. (1999) [4]
|
>
40
|
25.7
|
|
|
China
|
Wang
et al. (1997) [5]
|
>
40
|
73.1
|
18.2
|
|
Japan
|
McKinlay
et al. (1998) [6]
|
40~70
|
71
|
34
|
Nicolosi
et al. (2003) [7]
|
40~70
|
|
|
|
Korea
|
Ahn
et al. (1998) [8]
|
>
50
|
58.9
|
17.1
|
|
Malaysia
|
Nicolosi
et al. (2003) [7]
|
40~70
|
|
22
|
|
Singapore
|
Tan
et al. (1999) [9]
|
>
40
|
58.5
|
23.3
|
|
Thailand
|
Kongkanand
(2000) [10]
|
40~70
|
37.5
|
18.4
|
References
[1] Beilin J, Chew
G, Feddema P, OLeary P. Testosterone levels in aging males: a
population-based study utilizing measurement of total and calculated
bioavailable testosterone. Abstract Book, Annual Meeting &
Clinical Laboratory Expo. 54th Annual Meeting 2001 of American
Association of Clinical Chemistry.
[2] Earle CM, Stuckey BGA. Biochemical screening in the assessment
of erectile dysfunction: what tests decide future therapy? In Chew
KK: Prevalence of male hypogonadism and of erectile dysfunction
in Australia. The Abstract Book, Second Asian ISSAM Meeting on
the Aging Male, March 2003, Taipei.
[3] Chew KK, Earle CM, Stuckey BGA, Jamrozik K, Keogh EJ. Erectile
dysfunction in general medical practice: prevalence and clinical
correlates. Int J Imp Res 2000; 12: 1-5.
[4] Pinnock CB, Stapleton AM, Marshall VR. Erectile dysfunction
in the community: a prevalence study. Med J Austr 1999; 171:353-7.
[5] Wang YX, Leng J, Vhen B, Huang XY. The prevalence of erectile
dysfunction in elder adults in Shanghai (An analysis of 1582 cases).
Int J Imp Res 1997; 9: S45.
[6] McKinlay JB, DiGluttolo L, Glasser D, Sweeney M, Shirai MF.
International differences in the epidemiology of male erectile dysfunction.
Int J Imp Res 1998; 10: S42.
[7] Nicolosi A, Moreira ED Jr, Shirai M, Mohd Tambi MI, Glasser
DB. Epidemiology of erectile dysfunction in four countries: cross-national
study of the prevalence and correlates of erectile dysfunction.
Urology 2003; 61:201-6.
[8] Ahn TY, Chung TG, Lee JH, Kim T, Park T. Relationship between
lower urinary tract symptoms (LUTS) and erectile dysfunction (ED):
epidemiologic study in Jeong-Eup, Korea. Int J Imp Res. 1998;
10: S11.
[9] Tan JKN, Hong CY, Png DJC, Wee S, Liew L. A population-based
study on the prevalence of erectile dysfunction in an Asian population:
preliminary results. Proceedings of 9th Malaysian Urological
Conference. 1999 p 84.
[10] Kongkanand A. Thai Erectile Dysfunction Epidemiological Study
Group. Prevalence of erectile dysfunction in Thailand Int J Androl
2000; 23: 77-80.
The 2nd APSSAM Meeting
on the Aging Male
(6-9 March 2003, Taipei)
Han Sun CHIANG
Chairman, Organising Committee
The Second Meeting
of the Asia Pacific Society for the Study of the Aging Male (APSSAM)
was held in Taipei from 6 March to 9 March 2003. A total of 432
delegates from 20 countries attended the Meeting. The scientific
program included workshops, plenary lectures, panel discussions,
symposia as well as oral and poster presentations of free papers.
There were also three satellite symposia sponsored by Pfizer, Eli
Lilly and Bayer to present and discuss the recent advances in the
use of orally effective medications for the treatment of male erectile
dysfunction.
Topics discussed at
the Meeting cover many fields related to problems in the aging male.
There has been a significant progress in the research of male climacterics,
hormone replacement therapy, osteoporosis, epidemiology and clinical
management of prostate cancer in Asia, obesity, diabetes, neurological
and psychiatric disorders, sexually transmitted diseases, erectile
dysfunction, voiding dysfunction and molecular biology of the aging
process. The conference would have succeeded in adding knowledge
and updating information concerning the Aging Male in the Asia-Pacific
region, as well as advancing expertise in the management of the
aging male patients in clinical practice.
The Meeting also provided
a good opportunity for the members of APSSAM to be together to discuss
the very important issue of establishing in their respective countries
a national policy dealing with problems of aging population. Issues
concerning the quality of life and social life of the Aging Male
in the Asian societies were widely discussed. Most of the members
reported the prevalence of male hypogonadism and erectile dysfunction
of their countries, Further studies in these areas will undoubtedly
lead to a better understanding of the Aging Male in the Asia-Pacific
region. APSSAM is keen to conduct an investigation which may provide
consensus guidelines for the diagnosis and management of male hypogonadism.
As Chairman of the
Organising Committee, I would like to express my personal appreciation
for the kind help from members of APSSAM, especially from the former
President, Dr HM Tan, who gave me so many suggestions about the
conference from his own experience. I also wish to thank all of
the delegates for their attendance at the Meeting. I hope we can
work together even more concretely in the future for the further
advancement in the study of the Aging Male in Asia-Pacific countries. |