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Yi-Xun Liu |
Academician, Research Professor
State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080 P.R. China.
Tel: +86-010-64807038 Fax: 010-64807038
Email: liuyx@ioz.ac.cn |
Brief CV
Birth, October 5, 1936; Chairman of Academic Committee of State Key Laboratory of Reproductive Biology; Chairman of Chinese Society for Reproductive Biology; Director of WHO/Rockefeller Foundation Implantation Network, China Center (1999-2004); Editorial Board of "Human Reproduction" (UK, 1995-2002); "Achives of Andrology" (USA,2002-)," Asia J Andrology" (2005-); Frontiers in Bioscience (USA, 2005-) Managing Editor； Endocrine (USA, 2006-); Vice Editor-in-Chief of ?Developmental Reproductive Biology" (1987-2003) and "Science in China"; "Acta Zoologica Sinica"; "Acta Physiologica Sinica". At present, professor professorLiu has also served as the directors in China for other 6 Academic Committees of Key laboratories, such as Jongsu Key laboratory of Reproductive Medicine (in Nanjing University of Medical College);Liao-Ning Key laboratory of Reproductive Health; Senyang Key laboratory of Air pollution and Human Health; Shangdon Key laboratory of Reproductive Genetic and Birth Defect Diagnosis; Ning-Xa Key laboratory of Reproductive Biology and Genetics.
Professor Liu has spent more than 6 years in collaboration with distinguished Scientists in UK, USA and Sweden since 1974 and made a great contribution in the research area of ovarian function and its regulation. He is the first to demonstrate that progesterone produced by granulosa cells (GC) can be used by theca-interstitial cells (TIs) to convert into androgen which has been known as the substrate of aromatases in GC; and he further demonstrated that interaction of GC and TI is the prerequisite for ovarian estrogen production; He is also the first to prove that interaction of tissue type plasminogen activator (tPA) produced by GC and cumulus-oocyte complexes and plasminogen activator inhibitor type-1(PAI-1) secreted by TI, under the action of gonadotropins, induces ovulation. Professor Liu has published more than 200 papers, of which 120 papers in SCI journals and well quoted by more than 1300 SCI papers. Because of his great contribution, he has been awarded with the CAS first class of Natural Science Prize once, and the Second Class of Natural Science Prize for 5 times. In 2005, he was awarded with ?the 5th China Population Science /Technology? Prize. In 2006 he was awarded with ?China Population and Family planning Science /Technology? Prize. In 2008, he was nominated as an outstanding teacher by the Science/Technology University of Chinese Academy of Sciences. So far more then 40 postdocterial, Ph.D and Master students under professor Liu? supervision have graduated from the Institute.
Education and Scientific Research
1958.04-1963.09: Undergraduate Student, Department of Physiology, Fudan University, Shanghai. Graduated in 1963
1963.08-1967.08: Graduate student of reproductive endocrinology in Institute of Zoology, Chinese Academy of Sciences, Beijing, and graduated in 1967 (advisor: Prof. Chang, C.Y.)
1967.08-1972.09: Reproductive Biologist, working in Institute of Zoology, Chinese Academy of Sciences, Beijing
1972.09-1974.03: Beijing Language College: English training
1974.04-1975.12: Biochemistry, Department of Biochemistry, Imperial Cancer Research Fund, London, England
1976.01-1984.02: Assistant Professor, Research group leader, Department of Endocrinology, Institute of Zoology, Chinese Academy of Sciences, Beijing
1984.03-1986.12: Biochemistry and Physiology, Dept. of Reproductive Medicine. University of California, San Diego, CA, USA
1987.01-1988.09: Associate Professor of reproductive biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, Vice Chairman of Department of Endocrinology
1988.09-1989.05: Visiting Scientist, Molecular Biology, Unit for Applied Cell and Molecular Biology, Ume?University, Sweden.
1989.06-present: Professor and Director, Department of Endocrinology; State Key Lab of Reproductive Biology, Institute of Zoology, CAS
1990.03-1991.04: Visiting Professor. Molecular Biology, Unit for Applied Cell and Molecular Biology, Ume?University, Sweden.
1992.07-1992.10: Visiting Professor, Molecular Biology, Unit for Applied Cell and Molecular Biology, Ume?University
1995.11-1997.09: Visiting professor (3 monthes per year), Anatomy Research Laboratory in Department of Pre-Clinical Sciences, Leicester University, UK.
1999.01-2001.12: Honor professor, Department of Pre-Clinical Sciences, Leicester University, UK
Awards
(01) Natural Science Award of Academia Sinica 1982 ( 2rd grade ) Preparation of Estrogen, Progesterone and Testosterone RIA kits for commercial use in China
(02) Beijing Award of Science and Technology 1983 (3rd grade) Studies on the Effect of Gossypol on anti-endometrisis
(03) Natural Science Award of Academia Sinica 1984 (2rd grade) Reproductive Physiology of Amphioxus
(04) Natural Science Award of Academia Sinica 1985 (2rd grade) Regulation and Extrapituitory Function of LH-RH and its Angonist
(05) Natural Science Award of Academia Sinica 1991 (2rd grade) Interaction and Regulation of Ovarian Granulosa and Theca-interstitial Cells
(06) Natural Science Award of Academia Sinica 1993 (3rd grade) The Role of Steroid and Steroid Receptors in the Precess of Implantation
(07) Natioal Science Award of Academia. Sinica 1996 (2rd grade) Studies on the Role of tPA and PAI-1 in Regulation of Luteal Regression and Spermatogenesis
(08) Science and Technology Award of State Family Planning Commission 1996 (2rd grade) Studies on the Regulation of Follicle Development and Luteal Regression
(09) Science and Technology Award of State Family Planning Commission 1996 (2rd grade) Studies on Epididymis factors Related to Sperm Maturation
(10) Natural Science Award of Academia Sinica 1997 (First grade) Studies on the Mechanism of Ovulation
(11) The 5th China Population Award 2005 (The highest Award in the field)
(12) China Population and Family Planning Science and Technology Award 2006
(13) Outstanding Teacher Prize 2008
Other honors
1. Postdoctoral Fellowship and Research Fund from Rockfeller Foundation 1984-1986
2. Visiting Professorial Fellowship from Swedish Medical Research Council 1991-1992
3. Visiting Professorship Sponsored by the Royal Society of UK and Academia Sinica (3 months per year) 1995- 1997
4. Visiting Program sponsored by Swedish Medical Research Foundation and NNFC 1998
5. Visiting professorship sponsored by the Royal Society of UK and NNSFC (3 months per year) 1999-2002
Research Funding and Projects
"973" Project: Molecular Basis of Heat Stress Action on Spermatogenesis and the Related Gene Clonning (2006CB504000) 2006.10-2011.10 The Major Research Project：Molecular Mechanism of Oocyte Maturation and Ovulation (2006CB944001) 2006.10-2011.10 CAS Invention Project: Molecular Basis of Germ Cell Apoptosis (KSCX2-YW-R-55), 2006.12-2010.12 NSFC Major Project: Molecular Mechanism of Spermatogenesis and Maturation (30230190) 2003.12-2007.12 NSFC Major Research Project: Signaling Basis of Granulosa Cell Differentiation in the Ovary (90208025) 2003.1-2007.12 Hong Kong/NSFC SupportedProject: Study on Trs4 Function in Spermatogenesis by Conditional Knockout Mice (30618005), 2007.1-2009.12 NSFC General Project:
(1) Molecular Mechanism of Inhibitory Effect of Prolactin and Endomethecin on Ovulation in Rat and Mouse (30570921) 2006.1-2008.12
(2) Molecular Basis of Different Hormone Inducing Ovulation in Mammals (30370200) 2004.1-2006.12
(3) Mechanism of Wt1 Gene Regulating Sex Gene Sox9 Expression (30600311), 2007.1-2009.12 Beijing NSF Project: Role of TSNHE and Rsh12 in Sperm Movement (5073032) 2007.1-2009.12
Main Contribution and Achievement
Professor Yi-Xun Liu has made a great contribution in the research area of ovarian function and its regulation in rodent and primate animals. He is the first to demonstrate that progesterone produced by ovarian granulosa cells (GC) can be used by the theca-interstitial cells (TI) to convert into androgen which has been known as the substrate of aromatases in GC, and the interaction of GC and TI is the prerequisite for ovarian estrogen production; He is also the first to provide primary evidence to show that interaction of tissue type plasminogen activator (tPA) produced by GC/oocyte and plasminogen activator inhibitor type-1(PAI-1) secreted by TI, under the action of gonadotropins, induces ovulation, and also play an important role in luteal regression in rat and monkey. Based on his serious studies he has proposed hypothesis of mechanism of ovulation and luteal regression in mammals, which has been world-wide recognized and cited by the authoritative scientists in the field, such as L.L.Espey (USA), J Eppig (USA), J.M. Bahr (USA), J.S. Richards (USA), T.E.Jr Curry(USA),B.K.Tsang(Canada),A.Tsafriri(Isreal),R.L.Stouffer(USA),D.M.Stocco(USA),Y.Yoshimura(Japan),G. Selstan (Sweden),J.Gilabert (Span).
In recent years Professor Liu has made further contribution in studies on regulation of spermatogenesis control and implantation process in non-human primate. He and his colleagues have cloned 7 genes related to spermatogenesis and have been examining their physiological functions in regulation of spermatogenesis/sperm maturation. They also established the primate models to investigate the mechanism of germ cell apoptosis induced by "heat-stress" and testosterone. Based on the evidence achieved they have proposed a possible combinative regimen of T and "local warming testis" for developing male contraceptive.
Supported by WHO/Rockefeller Foundation and CONRAD/CICCR Implantation Network, Professor Liu and his colleagues have studied the molecular mechanism of implantation in monkeys. The aim of the project would develop an anti-implantation contraception method used worldwide on the basis of this study. They have established well-defined cycling, pseudo-pregnant and pregnant rhesus monkey as the models to analyze expression of common molecules specifically related to angiogenesis, apoptosis or proteolysis in endometrium and implantation site. They have demonstrated that apoptosis, proteolysis and angiogenesis occur in the endometrium during the time of establishment of the implantation window and in the materno-fetal boundary of the implantation site at the early stages of placentation, and they provided data to show that compounds which could effectively affect apoptosis, or angiogenesis, or proteolysis in the endometrium and the implantation site were capable of effectively inhibiting implantation. Because of his achievement in field, he was nominated with the 5th "China Population Prize" in 2005 by the government, and "China Population and Family Planning Science&Technology Award" by the China Population and Family Planning Commission in 2006.
Publications (.html)
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