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Jia-Hao Sha |
Professor
The Executive Director of the Key Laboratory of Reproductive Medicine of Jiangsu Province, Nanjing Medical University, Nanjing 210029, China.
Tel: 0086-25-86862908 Fax: 0086-25-86862908
Email: shajh@njmu.edu.cn |
Education
1978.09-1982.07: Undergraduate, Nanjing Medical University, P. R. of China.
1985.09-1988.12: Master's student, Nanjing Medical University, P. R. of China.
1999.09-2002.07: Ph.D student, Nanjing Normal University, P. R. of China.
Current Fields of Interest & Personal Statement
Professor Sha Jiahao focuses on the research of Reproductive Medicine. He is interested in infertility and the molecular mechanism of gametogenesis. In recent years, he has been responsible for two 973 Program projects, two key NSFC projects, one NSFC project for outstanding young researchers, two NSFC projects and a series of related provincial projects. His research has been very fruitful: He has submitted 111 novel genes to GenBank and published more than 60 papers in international journals. He is honored as an excellent scientist and teacher by both the provincial and state governments.
Publications
Cui Y, Zhu H, Zhu Y, Guo X, Huo R, Wang X, Tong J, Qian L, Zhou Z, Jia Y, Lue YH, Hikim AS, Wang C, Swerdloff RS, Sha J. Proteomic Analysis of Testis Biopsies in Men Treated with Injectable Testosterone Undecanoate Alone or in Combination with Oral Levonorgestrel as Potential Male Contraceptive. J Proteome Res. 2008 Sep 5;7(9):3984-3993. Hu Y, Xing J, Chen L, Guo X, Du Y, Zhao C, Zhu Y, Lin M, Zhou Z, Sha J. RGS22, A Novel Testis-Specific Regulator of G-protein Signaling Involved in Human and Mouse Spermiogenesis along with GNA12/13 Subunits. Biol Reprod. 2008 Aug 13. [Epub ahead of print] Related Articles, LinksZhang J, Wu J, Huo R, Mao Y, Lu Y, Guo X, Liu J, Zhou Z, Huang X, Sha J. ERp57 is a potential biomarker for human fertilization capability. Mol Hum Reprod. 2007 Sep;13(9):633-9. Lu Y, Huo R, Yuan Y, Li J, Shi Q, Sha J. Human testicular protein NYD-SP16 is involved in sperm capacitation and the acrosome reaction. Fertil Steril. 2006 Oct;86(4 Suppl):1228-34. Zheng Y, Zhang J, Wang L, Zhou Z, Xu M, Li J, Sha JH. Cloning and characterization of a novel sperm tail protein, NYD-SP28. Int J Mol Med. 2006 Dec;18(6):1119-25 Zhao C, Huo R, Wang FQ, Lin M, Zhou ZM, Sha JH. Identification of several proteins involved in regulation of sperm motility by proteomic analysis. Fertil Steril. 2006 Oct 27; [Epub ahead of print] Zhu YF, Cui YG, Guo XJ, Wang L, Bi Y, Hu YQ, Zhao X, Liu Q, Huo R, Lin M, Zhou ZM, Sha JH. Proteomic analysis of effect of hyperthermia on spermatogenesis in adult male mice. J Proteome Res. 2006 Sep;5(9):2217-25. Du Y, Huang XY, Li JM, Hu YQ, Zhou ZM, Sha J. Human testis specific protein 1 expression in human spermatogenesis and involvement in the pathogenesis of male infertility. Fertil Steril. 2006;85(6):1852-1854. Lu L, Lin M, Xu M, Zhou ZM, Sha JH. Gene functional research using polyethylenimine-mediated in vivo gene transfection into mouse spermatogenic cells. Asian J Androl. 2006;8(1):53-59. Hu YQ, Lu Y, Zhou ZM, Du Y, Xing J, Wang L, Lin M, Sha JH. Defective expression of Galpha12 in the testes of azoospermia patients and in the spermatozoa with low motility. J Mol Med. 2006 May;84(5):416-424. Huang M, Wang H, Li JM, Zhou Z, Du Y, Lin M, Sha J. Involvement of ALF in human spermatogenesis and male infertility. Int J Mol Med. 2006 Apr;17(4):599-604. Wang L, Zhu YF, Guo XJ, Huo R, Ma X, Lin M, Zhou ZM, Sha JH. A two-dimensional electrophoresis reference map of human ovary. J Mol Med. 2005;83:812-821. Huang XY, Zhou ZM, Yin LL, Wang LR, Lin M, Zhou YD, Sha JH. Identification of a novel substrate for tyrosine kinase in human testes. J Nanosci Nanotechnol. 2005;5(8):1236-1239. Zhu H, Zhou ZM, Lu L, Xu M, Wang H, Li JM, Zhou ZM, Sha JH. Expression of a novel dipeptidyl peptidase 8 (DPP8) transcript variant, DPP8-v3, in human testis. Asian J Androl. 2005;7(3):245-255. Yuan W, Zheng Y, Huo R, Lu L, Huang XY, Yin LL, Li JM, Zhou ZM, Sha JH. Expression of a novel alternative transcript of the novel retinal pigment epithelial cell gene NORPEG in human testes. Asian J Androl. 2005;7(3):277-288. Zhou ZM, Ren X, Huang XY, Lu L, Xu M, Yin LL, Li JM, Sha JH. SMYD3-NY, a novel SMYD3 mRNA transcript variant, may have a role in human spermatogenesis. Ann Clin Lab Sci. 2005;35(3):270-277. Wang H, Zhou ZM, Lu L, Xu ZY, Sha JH. Cloning and characterization of a novel intronless lactate dehydrogenase gene in human testis. Int J Mol Med. 2005;15(6):949-953. Qian Y, Feng T, Chen J, Cai LB, Liu JY, Mao YD, Ding W, Sha JH. Pregnancies and births resulting from in vitro matured oocytes fertilized with testicular spermatozoa. Journal of Assisted Reproduction and Genetics. 2005;22(3):133-136. Qian Y, Shi WQ, Ding JT, Liu JY, Sha JH. Fan BQ. Effects of type and state of co-culture cells on in-vitro development of porcine oocytes matured and fertilized in vitro. Journal of Assisted Reproduction and Genetics. 2005;22(6):233-238. Yin LL, Li JM, Zhou ZM, Sha JH. Identification of a novel testis-specific gene and its potential roles in testis development/spermatogenesis. Asian J Androl. 2005;7(2):127-137. Zhang XD, Yin LL, Zheng Y, Lu L, Zhou ZM, Sha JH. Expression of a novel beta adaptin subunit mRNA splice variant in human testes. Asian J Androl. 2005;7(2):179-188. Lu L, Zhou ZM, Huang XY, Xu M, Yin LL, Wang H, Xu ZY, Sha JH. Identification and characterization of cul-3b, a novel hominine CUL-3 transcript variant. Asian J Androl. 2005;7(2):205-211. Zheng Y, Yuan W, Zhou ZM, Xu M, Sha JH. Molecular cloning and expression of a novel alternative splice variant of BRDT gene. Int J Mol Med. 2005;15(2):315-321. Zheng Y, Zhou ZM, Xu M, Li JM, Sha JH. Identification and characterization of the BGR-like gene with a potential role in human testicular development/spermatogenesis. Asian Journal of Andrology. 2005;7(1):21-32. Qian Y, Feng T, Chen J, Cai LB, Liu JY, Mao YD, Ding W, Sha JH. Fertilization of in vitro matured human oocytes by intracytoplasmic sperm injection(ICSI) using ejaculated and testicular spermatozoa. Asian Journal of Andrology. 2005;7(1):39-43. Huang XY, Li JM, Lu L, Xu M, Xiao JH, Yin LL, Zhu H, Zhou ZM, Sha JH. Novel development-related alternative splices in human testis identified by cDNA microarrays. Journal of Andrology. 2005;26(2):189-196. Huo R, Zhu H, Lu L, Yin LL, Xu M, Xu ZY, Li JM, Zhou ZM, Sha JH. Molecular cloning, identification and characterics of a novel isoform of carbamyI phosphate synthetase I in human testis. Journal of Biochemistry and Molecular Biology. 2005;38(1):28-33. Wang H, Huo R, Xu M, Lu L, Xu Z, Li JM, Zhou ZM, Sha JH. Cloning and Characterization of a Novel Transcript Variant of IQGAP2 in Human Testis. DNA Seq. 2004;15(5-6):319-25. Huang XY, Zhang J, Lu L, Yin LL, Xu M, Wang YQ, Zhou ZM, Sha JH. Cloning and expression of a novel CREB mRNA splice variant in human testis. Reproduction. 2004;128:775-782. Hu YQ, Zhou ZM, Huang XY, Xu M, Lu L, Xu ZY, Li JM, Sha JH. Expression of a novel DnaJA1 alternative splicing in human testis and sperm. International Journal of Andrology. 2004;27:343-349. Zhu H, Chan HC, Zhou ZM, Zhu H, Yin LL, Xu M, Cheng LJ, Sha JH. A gene encoding Sialic-Acid-Specific 9-O-acetylesterase found in human adult testis. Journal of Biomedicine and Biotechnology. 2004;3:130-136. Zheng Y, Zhou ZM, Yin LL, Li JM, Sha JH. Molecular cloning and characterization of a novel splicing variant of PIASx1. Acta Pharmacol Sin. 2004;25 (8):1058-1064. Diao FY, Xu M, Hu YQ, Li JM, Xu ZY, Lin M, Wang LR, Zhou YD, Zhou ZM, Liu JY, Sha JH. The molecular characteristics of olycystic ovary syndrome (PCOS) ovary defined by human ovary cDNA microarray. Journal of Molecular Endocrinology. 2004;33: 59-72. Huo R, Zhu YF, Ma X, Lin M, Zhou ZM, Sha JH. Differential expression of glucose-regulated protein 78 during spermatogenesis. Cell and Tissue Research. 2004;316(3):359-367. Huang XY, Wang H, Xu M, Lu L, Xu ZY, Li JM, Zhou ZM, Sha JH. Expression of a novel RAD23B mRNA splice variant in human testis. Journal of Andrology. 2004; 25(3):363-368. Fang X, Zhou ZM, Lu L, Yin LL, Li JM, Zheng Y, Wang H, Sha JH. Expression of a novel pyridoxal kinase mRNA splice variant, PKH-T, in human testis. Asian Journal of Andrology. 2004;6(2):83-91. Zhu H, Zhou ZM, Huo R, Huang XY, Lu L, Lin M, Wang LR, Zhou YD, Li JM, Sha JH*. Identification and Characteristics of a Novel E1 Like Gene nUBE1L in Human Testis. Acta Biochimica et Biophysica Sinica. 2004; 36(3): 227-234. Wang H, Xu M, Li JM, Xiao JH, Xu ZY, Zhou ZM, Sha JH. A Spermatogenesis-related gene expression profile in Human Spermatozoa and Its Potential Clinical Application. Journal of Molecular Medicine. 2004; 82:317-324. Zhu H, Zhu JX, Lo PS, Li J, Leung KM, Rowlands DK, Tsang LL, Yu MK, Jiang JL, Lam SY, Chung YW, Zhou ZM, Sha JH, Chang Chan H. Rescue of defective pancreatic secretion in cystic-fibrosis cells by suppression of a novel isoform of phospholipase C. Lancet. 2003;362:2059-2065. Xu M, Xiao JH, Chen J, Li JM, Yin LL, Zhu H, Zhou ZM, Sha JH. Identification and characterization of a novel human testis-specific Golgi protein, NYD-SP12. Molecular Human Reproduction. 2003;9(1):9-17. Cheng LJ, Li JM, Chen J, Ge YH, Yu ZR, Han DS, Zhou ZM, Sha JH. NYD-SP16, a novel gene associated with spermatogenesis of human testis. Biology of Reproduction. 2003;68(1):190-198. Sha JH, Zhou ZM, Li JM, Lin M, Zhu H, Zhu H, Zhou YD, Wang LR, Wang YQ, Zhou KY. Expression of a novel bHLH-Zip gene in human testis. Asian Journal of Andrology. 2003; 2:83-88. Cheng LJ, Zhou ZM, Li JM, Zhu H, Zhu H, Zhou YD, Wang LR, Lin M, Sha JH. Expression of a novel HsMCAK mRNA splice variant,tsMCAK gene in human testis. Life Science. 2002;71(23):2741-2757. Yin LL, Li JM, Zhu H, Lin M, Cheng LJ, Wang YQ, Zhou ZM, Sha JH. Identification and characterization of a gene coding novel isoform of DEAD-box protein presumably involved in spermatogenesis. Reproduction, Fertility and Development. 2002; 14(3):125-131. Sha JH, Zhou ZM, Li JM, Yin LL, Yang HM, Hu GX, Luo M, Chan HC, Zhou KY. Identification of development/spermatogenesis-related genes in human and mouse testes using cDNA arrays. Molecular Human Reproduction. 2002; 8(6):511-517. Xiao JH, Xu M, Li JM, Chan HC, Lin M, Zhu H, Zhang W, Zhou ZM, Zhao BG, Sha JH, et al. NYD-SP6, a novel gene potentially involved in regulating testicular development/spermatogenesis. Biochem Biophys Res Commun. 2002; 291(1): 101-10. Zhou ZM, Sha JH, Li JM, Lin M, Zhu H, Zhou YD, Wang LR, Zhu H, Wang YQ, Zhou KY. Expression of a novel reticulon-like gene in human testis. Reproduction. 2002,123:227. Zhu H, Zhou ZM, Li JM, Zhu H, Cheng LJ, Shan YX, Yin LL, Sha JH. Cloning and characterization of a novel isoform of calpastatin in human adult testis. Acta Pharmacologica Sinica. 2002;23(5):450-454. Xiao JH, Yin LL, Li JM, Zu H, Zhou ZM, Zhao BG, Sha JH. Molecular cloning, Identification and characteristics of NYD-SP9: gene coding protein kinase presumably involved in spermatogenesis. Chinese Science Bulletin. 2002;47(11): 896-901. Baker BJ, Sha JH, McBride MW, Peng LH, Payne AH, O?Shaughnessy PJ. Expression of 3β-hydroxysteroid dehydrogenase type I and type VI isoforms in the mouse testis during development. Eur J Biochem. 1999;260: 911-916. Sha JH, Dudley K, Rajapaksha WRAKJS, O?Shaughnessy PJ. Sequence of mouse 17β-hydroxysteroid dehydrogenase type3 cDNA and tissue distribution of the type 1 and type 3 isoform mRNAs. J Steroid Biochem Molec Biol. 1997;60:19-24. Baker BJ, Sha JH, O?Shaughnessy PJ. Localisation and regulation of 17β-hydroxysteroid dehydrogenase type 3 mRNA during development in the mouse testis. Molecular and Cellular Endocrinology. 1997;133:127-133.
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