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Chawnshang Chang |
Professor
University of Rochester Medical Center, 601 Elmwood Ave. Box 626, NY 14642, USA.
Tel: 585-2759994 Fax: 585-7564133
Email: chang@urmc.rochester.edu |
Education
1974-1978: B.S., National Taiwan University (Agriculture Chemistry)
1978-1980: R.O.T.C., Army Chemical School (Nuclear Chemistry & Biology)
1980-1985: Ph.D., University of Chicago (Biochemistry & Molecular Biology)
1985-1988: Post Dr., University of Chicago (Molecular Endocrinology)
Academic Experience
1988-1990
1990-2000
1998-present
1999-present
1997-2002
1997-present
1997-present
2000-present |
Assistant Professor and Director, Urology Research Labs, Dept. of Surgery/Urology and Ben May Institute for Cancer Research, University of Chicago, Chicago, IL.
Assistant Professor (90-93), Associate Professor (93-96), Professor (96-97). Visiting Professor (97-00), Director, Tissue & Blood Bank (90-97). Departments of Human Oncology and Medicine and UW Comprehensive Cancer Center, UW-Madison, WI.
Visiting Professor, Osaka University, Yokohama University, Japan; Peking University and Xiamen Univ. ,Wuhan Univ., Tianjin Medical Univ, China.
Visiting Prof., Chang Gung Univ./National Taiwan Univ./Taipei Medical Univ.
Director, Molecular Oncology Graduate Program. Univ. of Rochester, Rochester, NY.
Director, George Whipple Laboratory for Cancer Research, Univ. of Rochester.
Director, Urology Research Center, University of Rochester, Rochester, NY.
George Whipple Distinguished Professor, Departments of Pathology, Urology and Radiation Oncology, and The Cancer Center, University of Rochester, Rochester, NY.
Founder, AndroScience Corporation. San Diego, CA. |
Honors
1988
1989
1990
2003
1992
1991-1994
1995-1997
1991-1997
1996
1998
1998
1998
1999
1999
2000
2001
2001
2001-present
2002 |
The Ayerst Award for Outstanding Young Endocrinologist from the Endocrine Society
Andrew Melon Award for Outstanding Young Faculty in USA from Andrew Melon Foundation
Outstanding Young Investigator Award from Cancer Research Foundation
The Milheim Award for Excellence in Cancer Research from Milheim Foundation
Tokyo Society of Medical Science and University of Tokyo Lecturer
American Cancer Society Junior Professorship in Cancer Research
Blowity-Ridgeway Award in Andrology from Blowity-Ridgeway Foundation
CapCure Award (6 times) for Excellence in Prostate Cancer Research
Award with Honorary Fellow from The Japan Society of Andrology (The 2nd Non-Japanese ever awarded such honor)
Scholar of the Year, The highest honor from The Taiwanese Osteoporosis Association for Outstanding Contribution in Sex hormones and Osteoporosis.
George Hoyt Whipple Lecture, University of Rochester, Rochester, NY.
Jiepimg Wu Award, for Outstanding Achievement in Urology (The highest honor for Chinese-Urology Researcher). Beijing, China.
President Award for Outstanding Urology Research, The highest honor from The Urology Association of Taiwan for the Contribution in Androgen Receptor and Prostate Cancer.
Davey Memorial Award for Outstanding Cancer Research, University of Rochester.
President Award for Outstanding Andrology Research, The highest honor from The Taiwanese Andrology Association for the studies of Androgens and Androgen Receptor.
Who?s Who in America
Dr. S.T.Huang-Chan memorial Lecture/Award, University of Hong Kong.
Award for Outstanding Andrology Research, The highest honor from The Chinese Andrology Association for the studies of Androgens and Androgen Receptor.
Dr. Chien-Tien Hsu Memorial Lecture/Award at 2002 Annual Meeting of OBGYN |
Grant and Publication Review
Member of Editorial Board, Endocrine (2000-) Member of Editorial Board, The Prostate Journal(2002) Member of Editorial Board, The Prostate(2003-) Member of Editorial Board, Neuroimmune biology (2002) Reviewer in PNAS/JBC/Mol Endo/Cancer Research and 16 other peer-reviewed journals NIH Study Section: Ad Hoc & Regular Member at Biochemical Endocrinology & Other Study Section (1995-2001) NIH Study Section: Ad Hoc & Regular Member at Reproductive Endocrinology (2003) VA Merit Grant Oncology Study Section (1996-2002) NIH Prostate SPORE P50 Center Grant; and NIH PO1 Core Grant, NIH Research Centers in Minority Institutes Core Grant, NIH P19 Orphan Receptor Center Grant. ARMY Breast and Prostate Cancer Grant Study Section (1999-) Air Force TCDD Grant (reviewer) (2001) Medical Research Council of Canada and Dutch Cancer Society Grant Taiwan CRC Biomedical Sciences Project and Taiwan National Science Council Grant Hong Kong Earmarked Research Grant; Italian Association for Cancer Research
Teaching: (all in University of Rochester)
1. Cancer Biology (3 credit, course director)
2. Biochemistry of Steroid Hormones
3. Current Topic in Pathology and Oncology
4. Signal Transduction (2 hours lecture)
5. Toxicology (2 hours lecture)
6. Epidemiology (2 hours lecture)
7. Hormones and Cancer
8. Graduate Independent Study (current 15 Ph.D. students
Current Research Grants: direct cost only (59% extra indirect cost for U of R)
2003-2006
2003-2007
2002-2007
1993-2000
2002-2006
2001-2005
2001-2004
2002-2004
1997-2022 |
DOD-ARMY Grant, Years 1-3 ($375,000), P.I., Knockout AR in Prostate.
NIH RO1 Grant DK61222, Years 1-4 ($900,000), P.I., TR2 & TR4 knock-out mice.
NIH RO1 Grant DK60948, Years 1-5 ($875,000), P.I., PTEN in prostate cancer.
NIH RO1 Grant CA103006, Years 1-3 ($600,000), P.I., AR in prostate -bone.
NIH RO1 Grant DK60905, Years 1-4 ($700,000), P.I., Induction of AR transactivation by DHT vs E2.
NIH RO1 Grant DK56984, Years 1-4 ($700,000), P.I., TR4 orphan receptor in testis & prostate.
ARMY Prostate Research Grant ($375,000), P.I., suppression of AKT signal in prostate cancer.
ARMY Research Grant ($300,000), P.I., PTEN in breast cancer.
George Whipple Professorship Endowment for 25 years |
Grant and Publication Review
1995-2003: NIH RO1 Grant DK47258, Year 1-8 ($1,517,400), P.I., TR2 & TR3 orphan receptors in prostate cancer. 1997-2002: NIH RO1 Grant CA71570, Years 1-5 ($806,592), P.I., Title: AR coregulators in prostate carcinogenesis. 1993-2001: NIH RO1 Grant CA55639, Years 1-9 ($569,349), P.I., Title: T vs DHT effects in prostate cancer. 1995-1997: Hollis-Eden Research Award ($60,000) Title: DHEA-derivatives receptor. 1998-2000: NIH-NCI Research Grant Contract ($180,000), P.I., Title: ARA-A1B1 CAG repeat polymorphism 1998-2001: ARMY Prostate Research Grant ($486,000), Co-P.I. (PI: Harrison.) Title: Androgen effects on LNCaP prostate cancer cell growth 1997-2001: Rhone-Poulenc Rorer Research Award ($50,000) Title: AR Coregulators 1995-2000: NIH RO1 Grant DK51346, Years 1-5($950,815), P.I., AR CAG polymorphism 1998-2000: NIH Training Grant ($60,000 for Drs. Young & Yeh to study in P.I.? lab) 1999-2002: CaP CURE Research Award ($600,000), P.I., The roles of AR in prostate 1995-1998: NIH Research Grant CA 23563 ($465,433) Co P.I.(P.I.:Verma) 1993-1997: NIH Research Grant P30 CA 14520 ($210,000), P.I.(Tissue Bank Project) 1992-1997: NIH Research Grant CA 10536 ($607,331) Co P.I.(P.I.:Weindruch) 1996-1997: The Blowity-Ridgeway Foundation Award ($120,000), P.I. 1996-1997: Glaxo Research Fund ($35,000), P.I. 1992-1997: Taiwan National Science Council ($100,000 for 2 scientists studying in lab) 1990-1997: NIH Research P30 CA 14520. Co Investigator, 30% salary support 1995-1996: UW Comprehensive Cancer Center Award ($14,000), P.I. 1995-1996: UW Graduate School Research Award ($10,000), P.I. 1994-1996: Triton Research Fund ($21,400), P.I. 1994-1996: UW Medical School Merit Award ($65,000), P.I. 1994-1996: Anderson Research Fund($23,000), P.I. 1994-1995: CaP CURE Research Award ($100,000), Co P.I. (P.I.: Messing) 1994-1995: Adria Research Fund ($20,000), P.I. 1993-1994: NIH Training Grant ($40,000 for Dr. Lin to study in my lab) 1992-1994: Uehara Foundation ($20,000 for Dr. Kurada to study in my lab) 1992-1994: Shiseido Research Foundation ($35,000), P.I. 1991-1994: ACS Research Grant BE-78 and BE-78a ($314,968), P.I. 1991-1994: University of Wisconsin Grants (4 grants for total $106,000), P.I. 1990-1993: American Cancer Society Junior Faculty Award ($90,500) 1989-1991: Cancer Research Foundation Young Investigator Award ($40,000) 1989-1991: Milheim Foundation Young Investigator Award ($20,000) 1988-1991: American Cancer Society (ACS) Research Grants ($81,415), P.I. 1988-1989: Louis Block and Coleman Foundations ($45,000), P.I.
Patents
01. Androgen receptor and TR2 orphan receptor
02. Androgen receptor coregulators ARA70, ARA55, ARA54, ARA24, BRCA1, Rb
03. Using differential length of androgen receptor? and ARAs? CAG repeat to predict prostate cancer risk in Chinese population
04. Cross-talk between androgen receptor and other signal pathways (TGFb, Her2/Neu,MAPK, IL6/PI3K/AKT, PTEN, BRCA1, RB)
05. Using Aortic endothelial cells to screen SERMs
06. Vitamin E as anti-prostate cancer agent
07. Androgen receptor knock out mice
08. TR2 and TR4 knock out mice
09. Antiandrogen HF avtivates MAPK pathway in prostate cancer
10. Cucurmin analogs function as antiandrogen
Membership
1. The Endocrine Society
2. American Society for Biochemistry and Molecular Biology
3. American Association for Cancer Research
4. American Urology Association
Invited speaker and Publications (.doc)
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