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- Clinical Experience -
Pilot study to determine improvements in subjective penile
morphology and personal relationships following a Nesbit
plication procedure for men with congenital penile curvature
Giorgio Cavallini1, Stefano
Caracciolo2
1Andrological Operative Unit, Headquarters of Società Italiana di Studi di Medicina della Riproduzione via Mazzini 12,
Bologna 40138, Italy
2Section of General and Clinical Psychology, University of Ferrara _ Medical School, Via Fossato di Mortara 64b,
Ferrara 44100, Italy
Abstract
Aim: To determine whether the surgical straightening of congenital penile curvature can improve intromission comfort,
penile features, personal relationships and psychogenic erectile dysfunction (ED).
Methods: Fifty-four patients (mean age 24 years, range 20_31 years) whose congenital penile deviation due to physiological curvature was
¡Ý 25 degrees, as measured on a graph, and who were experiencing penetration discomfort were assessed specifically for
the present study. Of these, 14 patients suffered from psychogenic ED. The assessment included a case history, an
objective examination, a pharmacologically-induced erection with prostaglandin E1 10_20 g, a graph taken during
erection, a basal and dynamic Duplex ultrasonograph, penile length measurement, nocturnal penile tumescence recording,
hormonal profiles and a psychological interview to evaluate the quality of their personal relationships according to
Hinde's parameters (contents, number, features, frequency, ability to perceive limits of mutuality, subjective
perception of the other person[s], and reliability). All patients underwent the Nesbit procedure. The initial assessment was
repeated at 3 and 12 months after surgery. Data analyses were carried out using the z test.
Results: Subjective judgement of cosmetic penile features and vaginal intromission comfort improved significantly after surgery whereas
the quality of personal relationships and ED did not.
Conclusion: The surgical straightening of congenital penile
curvature improved intromission comfort and penile features, but it failed to improve interpersonal relationships or
psychogenic ED. (Asian J Androl 2008 May; 10: 512_519)
Keywords: congenital penile curvature; Nesbit procedure; penile surgery; personal relationships
Correspondence to: Dr Giorgio Cavallini, Andrological Operative Unit, Headquarters of Società Italiana di Studi di Medicina della Riproduzione
via Mazzini 12, Bologna 40138, Italy.
Tel: +39-0532-200-847 Fax: +39-0532-186-0287
E-mail: giorgiocavallini@libero.it
Received 2006-09-25 Accepted 2007-06-11
DOI: 10.1111/j.1745-7262.2008.00329.x
1 Introduction
The prevalence of congenital penile angulation without epispadias, hypospadias or spongiosal hypoplasia is
approximately 0.4/1 000 [1]. The most frequent type of angulation is ventral, sometimes associated with a lateral
curvature, or more rarely, torsion. Pure lateral angulations are rare [2]. A curvature greater than 25_30 degrees
affects vaginal intromission [3]. The range of ages at which men seek out medical consultation for this problem is
approximately 20_27 years [1, 3, 4]. The accepted therapy for congenital penile curvature is surgery if intercourse is
compromised or upon patient request; the rationale is to straighten the penile shaft to facilitate better intromission [1].
The main symptom of congenital penile curvature is
difficulty in vaginal intromission. Some studies sustain
that the embarrassment of the patients induced by their
subjective perception of their disfigured penis might
affect either their ability to begin/continue an affective
relationship [2, 4] or their erection [1, 2]. Despite the
absence of any proof, it is held that aesthetic surgery of
male genitalia [5], as well as aesthetic surgery of other
organs [6] is associated with an improvement in self
esteem. Although comfortable vaginal intromission and
satisfactory penile features, which are the outcomes in
the vast majority of patients undergoing surgery [1_3],
are the common primary endpoints of papers testing the
efficacy of this surgery, the improvement of the
subjective perception of penis features and of comfort in
vaginal penetration, which could modify psychogenic
ED and/or the social relationships of these patients, has
been studied little. Only Friedrich
et al. [4] analyzed the psychogenic aspect of this surgery, taking into
consideration quality of life (QoL). They reported that,
before surgery, sexual intercourse was uncomfortable or
impossible in 68% of the patients in their study, and that
the QoL was impaired in 84%. Of patients, 81% judged
the cosmetic results as satisfactory, 100% reported no
problems with sexual intercourse, but only 48% reported
an improvement in the QoL after surgery [4]. This
discrepancy between the surgical results and the
improvement in QoL might demonstrate that satisfactory
cosmetic results are not sufficient to improve the QoL for all
patients.
Therefore, we are compelled to explore whether
surgery can improve the subjective perception of penis
features, intromission ability, psychogenic ED and
social relationships simultaneously in patients affected by
congenital penile curvature.
2 Patients and methods
A single-arm open prospective trial was carried out
with a consecutive series of patients who had been
referred for congenital penile curvature limiting successful
vaginal intromission. The research was approved by the
Società Italiana di Medicina della Riproduzione (SISMER)
ethical committee and written informed consent was
obtained from each participant.
2.1 Patients
The patients were first assessed by an andrologist
(Giorgio Cavallini) and then by a psychologist (Stefano
Caracciolo). Two separate settings were used: private
clinics (Giorgio Cavallini) and university clinics (Stefano
Caracciolo).
All patients whose main complaints were congenital
penile curvature responsible for producing uncomfortable
vaginal intromission were eligible for the current study.
The cut-off angle of the curvature was > 25 degrees
according to the current published literature [6]. Patients
were not admitted to the study if any of the following
exclusion criteria were present: (i) Peyronie's disease (no
cases); (ii) previous penile fracture (no cases); (iii)
epispadias, hypospadias or spongiosal hypoplasia (2
cases); or (iv) hormonal alterations (no cases). The
patients were fully counselled on the 100% probability of
penile length loss with surgery.
2.2 Patient andrological management
This research was carried out exclusively by means
of interviews; the reasons for this are presented in the
discussion section.
Each patient underwent an initial assessment prepared
and carried out exclusively for the current study. The
assessment included a case history, an objective
examination (inspection and palpation of the penis and of the
testicles), a pharmacologically-induced erection using
intracavernosal prostaglandin E1 (PGE1) 10_20 g
(intracavernous injection [ICI] test), a photograph taken
during erection at an outpatient clinic according to the
Kelami procedure [7], a basal and dynamic (with intracavernosal PGE1 10 g) echo-color Doppler
ultrasonograph (performed with ESAOTE-AU5-EPI equipment,
a 7.5 MHz digital probe and a gel wedge), a penile length
measurement [8] and a nocturnal penile tumescence (NPT)
recording. The NPT recording was performed with RigiScan (Urohealth System
Corporation; Costa Masa, CA, USA); a rigidity increase > 70% above baseline at the
base of the penis and > 60% at the top, and a
circumference increase > 2 cm at the top of the penis and > 3 cm
at the base were considered "full erections". For three
consecutive nights, the total duration in minutes of the
patients' full erections were recorded; 3_6 full erections
per night, longer than 10 min each, were considered to be
the normal range [9]. Hormonal serum profiles
(follicle-stimulating hormone, luteinizing hormone, free and total
testosterone and prolactin) were also performed [9].
2.3 Patient psychological management
Psychological interviews were carried out for each
patient by a single unblinded clinical psychologist (Stefano
Caracciolo) before and after (3 and 12 months) surgery
to investigate the patients' interpersonal relationships.
Modifications in interpersonal relationships before and
after surgery were compared. Interpersonal relationships
are intended as social interactions and were defined
using Hinde's parameters [10]:
1. Contents: quality of oral translation of personal
feelings in the course of relationships.
2. Number: extension and variety of relationships.
3. Features: deepness and typology of relationships.
4. Frequency: rate and distribution of relationships.
5. Ability to perceive limits of mutuality: patient skill
in the evaluation of gains and/or losses in terms of
personal advantages from social relationships.
6. Subjective perception of the other person:
individual feeling towards other people: competitors, judges,
allies, etc.
7. Reliability: trust in interpersonal relationships.
The patients were operated on by a single surgeon
using the Nesbit procedure (Giorgio Cavallini). The
patients were instructed to avoid sexual intercourse for
2 months after surgery. Surgical complications were
recorded.
2.4 Variables assessed
The initial assessment was repeated at 3 and 12 months after surgery with the exclusion of hormonal
profiles, and basal and dynamic Duplex sonographs. The
following variables were assessed before and after
surgery:
1. Comfort of vaginal intromission.
2. Cosmetic penile features defined as satisfactory
or unsatisfactory based on whether patients were
embarrassed or not about their subjective perception of
penis features.
3. Penile length.
4. NPT (to ascertain whether the Nesbit procedure
interferes with nocturnal spontaneous erections).
5. The indications from Hinde's parameters as to an
improvement, worsening, or no change, based on the
patients' reports which were subjectively judged by the
psychologist.
6. Percentage of patients suffering from psychogenic
ED. ED was diagnosed as psychogenic in all cases on
the basis of clinical, psychological, instrumental and
laboratory outcomes [9, 11]. The fulfillment of this endpoint
was subjectively evaluated by Stefano Caracciolo during
the course of psychological interviews. There were no
cases of ED secondary to the Nesbit procedure.
In the current study we tested the hypothesis that
surgery would simultaneously improve (i) satisfaction
with the subjective perception of penis features; (ii) the
comfort of vaginal intromission; (iii) interpersonal
relationships; and (iv) psychogenic ED. As for the
efficacy of the surgery, the endpoint was the attainment of
all goals (i, ii, iii and iv). Furthermore, we attempted to
determine whether differences exist in penile length
between satisfied and dissatisfied patients with regard to
their subjective perception of penis features after surgery.
2.5 Statistical analysis
The amplitude of the sample was determined using
Bross' method of sequential analysis [12].
All data analyses were carried out according to a
pre-established analysis plan; the preoperative data were
compared with the postoperative data. Proportions were
compared using the z-test and means were compared using the Tukey test [12].
3 Results
The present study enrolled 64 eligible patients
between January 2, 1996 and May 31, 2004. Of these,
four patients refused the intervention (fear of surgery)
and six dropped out during the course of follow-up. A
telephone follow-up was carried out to determine the
reasons and it found that: (i) three patients sustained that
they did not need any psychological counselling; (ii) one
patient was called to military service; and (iii) two
patients were dissatisfied because they felt that their penis
was too short after surgery. Even though these last
patients are confirmed treatment failures, they were
eliminated from the study because they could not undergo
the planned postoperative assessments.
In total, results were available from 54 patients (mean
age 24 years, range 20_31 years). The baseline
demographic and clinical characteristics of the trial group are
presented in Table 1.
The patients were treated exclusively with the Nesbit
procedure [2]. There was a mean of 2.2 (range 1_3)
dorsal ellipses per part in the case of ventral deviation,
and a mean of 2.1 (range 1_3) dorsal-right ellipses in the
case of ventral + left deviation. Left deviation required
one right ellipse. Correct penile straightening was checked
with saline erection during the course of surgery, and with
auto-photography and ICI tests during follow-up. The
adverse effects of surgery were: transient (4 months)
glandular paresthesia (1 case), delayed healing of the
subcoronal incision (3 cases), postoperative bleeding
(1 case corrected with surgical haemostasis 8 h after
surgery) and paraphimosis (3 cases, corrected with
circumcision 15_30 days after the initial surgery).
Paraphimosis occurred in 3 out of 8 patients who wanted to
preserve their prepuce for aesthetic reasons.
The proportion of patients satisfied with their
cosmetic penile features and with the comfort of
intromission significantly improved after surgery (Table 2). Only
a non-significant percentage of patients reported a change
in their interpersonal relationships after surgery: three
reported that their interpersonal relationships had
worsened whereas four reported that they had improved.
Interviews indicated that no significant difference occurred
between pre-surgical and post-surgical percentages of
patients complaining about ED; 14 patients complained
about non-satisfactory penile rigidity and/or referred to
losing it completely in the course of sexual intercourse
and/or vaginal penetration attempts before surgery and
these reports did not change after surgery (Table 3).
These patients were all subsequently invited to partake
in psychotherapy sessions.
Nine patients complained about a subjective
excessive shortening of their penile shaft and, for this reason,
they were dissatisfied and three of them reported that
their relationships had worsened. A comparison of
penile length after surgery and of penile shortening because
of surgery between satisfied and non-satisfied patients
gave a negative result for significant difference
(F < 1 in both cases, P not significant, Table 4). Psychological
sessions revealed that these patients had very poor social
relationships before and after surgery; no patient had
previously had any sexual intercourse with any partner
but had had sexual intercourse with a prostitute. Of the
nine, seven routinely used narcotic drugs 4_7 days a
week, five had no deep friendships and three spent most
of their free time indoors by themselves.
Phosphodiesterase-5 inhibitors (PDE-5i) were not used as first line
treatment for psychogenic ED because these patients are
obliged to use PDE-5i every time they want to achieve a
suitable erectile response to a sexual stimulation; therefore,
the use of PDE-5i as a first line treatment for psychogenic
ED entails the risk of inducing a dependency on drugs
[10, 12]. Of the 14 patients complained about
non-satisfactory penile rigidity and/or referred to losing it
completely in the course of sexual intercourse, three used
PDE-5i as a second line treatment for ED: one because
he refused psychotherapy and two because psychotherapy failed to achieve any improvement of their ED.
All these patients reported that PDE-5i (Sildenafil 50 mg
in case of need) was effective.
Four patients reported improved interpersonal
relationships after surgery. They agreed to the surgery
because they had engaged in significant relationships with
women: one was embarrassed by his penile features and
three could not penetrate.
Nocturnal penile tumescence recordings were within
the normal range [9] and no significant difference was
found between pre-operative and post-operative full
erection periods during the course of three night recordings.
Full erection periods were always within the normal range,
and surgery did not significantly modify them:
preoperative NPT (mean ± SD) = 195 ± 22 min; postoperative
(at 3 months) NPT = 199 ± 20 min; postoperative (at
12 months) NPT = 196 ± 21 min
(F = 1.23, P not significant).
4 Discussion
The data collected herein indicate that surgical
penile straightening for congenital deviation significantly
improves subjective penile features, intromission
comfort and patient satisfaction of their subjective
perception of penis features, but these results rarely modified
personal relationships. Post-surgery penile length and
after surgery shortening did not significantly differ
between satisfied and dissatisfied patients, thus showing
that subjective perception of the penile aspect does not
depend on surgical shortening.
ED did not improve after surgery. Since sexual
intercourse represents an aspect of personal relationships
[11, 13], which did not improve with surgery, it is not
surprising that the patients studied still complained about
ED after the Nesbit procedure.
The causes of the negligible efficacy of surgery on
interpersonal relationships are unknown. A future study
could ascertain whether an individual personality trait is
involved. The initial project of this research included a
study of patient personality, but it was abandoned
because we noticed early on that the number of patients
who would benefit from surgery in terms of personal
relationships would be very low; we therefore concluded
that obtaining a representative number of patients to study
would have been extremely difficult.
A key aspect of the present study was the technique
used to assess interpersonal relationships.
The QoL and interpersonal relationships are regarded
as important psychological issues to be assessed in sexual
medicine [11, 13]. The QoL can sometimes be directly
related to "health" and explores, for example, energy and
work satisfaction, which are unrelated to sexual health
[13]; therefore, it was felt to be too broad an instrument
for testing the population studied. We carried out tests
prior to this research in the course of which QoL
assessment was determined to be too conditioned by the
emotional status of the patients related simply to cosmetic
penile features or to penetration comfort.
Interpersonal relationships are commonly assessed
using questionnaires or in the course of psychological
sessions [11, 13]. In a preliminary approach, scales were
used, but they proved unreliable because the data were
not replicable. A survey indicated that patients gave too
many evasive answers because they felt the scale items
were too intrusive regarding their intimate feelings. This
intrusion further provoked low patient compliance for
successive psychotherapy and the SISMER ethical
committee considered the use of experimental systems that
could interfere with any kind of therapy successive to
the research as unethical. Furthermore, even though
some trials used these scales, they are considered to have
limited clinical value [9, 13]. Therefore, we were
compelled to collect data on social relationships using
psychological semi-structured interviews. Hinde [10] fully
described the variables of personal relationships and
defined parameters that are accepted by the current
literature in the field [11]. These parameters were used in
psychological interviews to explore social relationships
because they are strictly interdependent and mutually
control each other [10, 11]. Repeated interviews with
the same patients using Hinde's parameters found
replicable data in the course of pre-surgical testing.
Interviewers blind to the treatment could not be used because
we immediately noticed that it was extremely difficult to
collect data about the efficacy of the surgery without
being able to discuss it. Subjective methods (i.e.
psychological sessions) were used as well to assess ED; in
our study, scales were not so reliable, mainly in the
patients with the worst social relationships. Additional ED
questionnaires were constructed for patients with stable
relationships, while 7/14 patients with ED had only
occasional (1_2 experiences in the course of 1_4 years)
and short (2_6 weeks) relationships, and 3/4 experienced
attempts of sexual intercourse only with prostitutes.
Multiple interviews in the course of pre-surgical testing
found replicable data.
This study used the Nesbit procedure exclusively
because (i) there is a higher recurrence rate of the
deviation with the simple placation as compared to a Nesbit
procedure [14]; (ii) the Nesbit procedure improves
erections in Peyronie's disease, even 4 years after surgery
[15]; and (iii) impairment of erection after the Nesbit
procedure occurs in patients already affected by ED prior
to surgery [16, 17]. Since 2002, Lue's team [18] has
been using a 16-dot plication technique to correct
congenital penile curvature, but we did not use it in this trial
for the sake of homogeneity.
The Nesbit surgical procedure can improve erections
via circumflex vein ligation, but it can also affect sexual
potency through a lesion of the dorsal neurovascular
bundle [9, 15]. The absence of any significant
difference between pre-surgery and post-surgery NPT
indicates that the Nesbit procedure did not significantly
influence erections. Actually, the improvement of
erections after the Nesbit procedure was found exclusively
in those suffering from Peyronie's disease [9, 15]. As a
confirmation, no significant difference emerged between
the pre- and postoperative data of penile artery spectral
traces. Spectral traces of the cavernosal and the dorsal
arteries are not so different in terms of velocity in our
research, although some series report that the dorsal
artery velocity is higher than the cavernosal velocity [9].
This is true mainly in the complete/rigid phase of erection,
although it has been recommended that arterial spectral
traces be measured 5_10 min after the PGE1 injections,
during the latency/tumescence phase [9].
The measurement of Rigidity Activity Units (RAU)
and Tumescence Activity Units (TAU) is an accepted
method for assessing NPT. Unfortunately, the
appropriate software was not available in our unit. However,
RAU and TAU measurements were introduced to simplify NPT quantification, but the absence of these
measurements does not modify NPT reliability [9, 13]. Even
though larger series regarding the Nesbit procedure have
used a longer follow-up (up to 90 months [17]), we
stopped postoperative follow-up empirically at 12 months
because the preliminary experience of our team in this
field showed that a longer follow-up affects patient
participation in psychotherapy; therefore, the SISMER
ethical committee did not allow longer periods of patient
observation (see above). The intention-to-treat analysis
is generally favoured to avoid the bias associated with a
non-random loss of participants. Therefore, it is mainly
used to analyze multiple arm trials. This is a single-arm
trial so conventional analyses were preferred [19]. A
survey of our data indicated that the intention-to-treat
analysis did not modify the significance or
non-significance of the results.
The validity of these data is the patients' complaint
of poor social relationships because of congenital
penile curvature. In most cases, this complaint should be
regarded as an ego defence [11] rather than as an
effect of the deformity. It is felt that psychological
intervention is mandatory to ensure satisfactory social
relationships in patients with congenital penile curvature
and problematic inter-relationships, especially in the cases
where ED is present.
Our data bring up doubts about the efficacy of
cosmetic surgery of the penis (i.e. surgery aimed at
improving dimensions) for the improvement of social
relationships of subjects undergoing this surgery. In fact, in the
literature, all papers concerning plastic surgery of male
genitalia deal with the penile dimension aspect but not
with interpersonal relationships before and after surgery
[5, 20_22].
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