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Asian Journal of Andrology (2012) 14, 69-76; doi:10.1038/aja.2011.69; published online 12 December 2011
Advanced paternal age and reproductive outcome
Zofnat Wiener-Megnazi, Ron Auslender and Martha Dirnfeld
Fertility and IVF Unit, Department of Obstetrics and Gynecology, Carmel Medical Center, the Bruce Rappaport Faculty of Medicine, Technion, Haifa 34362, Israel
Correspondence: Professor M Dirnfeld, (dirnfeld_martha@clalit.org.il)
Received 26 May 2011; Revised 26 July 2011; Accepted 9 September 2011; Published online 12 December 2011.
| Abstract |
Women have been increasingly delaying the start of motherhood in recent decades. The same trend is seen also for men. The influence of maternal age on fertility, chromosomal anomalies, pregnancy complications, and impaired perinatal and post-natal outcome of offspring, has been thoroughly investigated, and these aspects are clinically applied during fertility and pregestational counseling. Male aging and reproductive outcome has gained relatively less attention. The purpose of this review is to evaluate updated and relevant literature on the effect of paternal age on reproductive outcome.
Keywords: ART outcomes; fertility; male aging; paternal age; reproductive outcome |
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