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Asian Journal of Andrology (2012) 14, 338-340; doi:10.1038/aja.2011.171; published online 28 November 2011
Survey for late-onset hypogonadism among old and middle-aged males in Shanghai communities
Kai Sun1, Guo-Qing Liang2, Xiang-Feng Chen1, Ping Ping1, Wen-Liang Yao1, Shi-Jun Zhang1, Bo Wang3, Ying-Hao Sun4 and Zheng Li1
1 Department of Urology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China
2 Department of Urology, Shanghai Hospital of TCM, Shanghai 200071, China
3 Family Planning Research Institute of Shanghai City, Shanghai 200032, China
4 Department of Urology, Shanghai Hospital, Second Medicinal Military University of PLA, China, Shanghai 200433, China
Correspondence: Dr Z Li, (doc.zheng.li@gmail.com); Dr YH Sun, (profsunyinghao@hotmail.com)
Received 6 September 2011; Revised 22 September 2011; Accepted 9 November 2011
Advance online publication 28 November 2011
| Abstract |
This study sought to investigate late-onset hypogonadism (LOH) in old and middle-aged males in Shanghai communities, using symptom score evaluation systems and measurements of sex hormone levels. One thousand cases of males aged 40–70 years were investigated. The aging male symptoms (AMS) scale and androgen deficiency in aging males (ADAM) questionnaire were used at the beginning of the investigation, followed by measurement of the sex hormone-related factors (total testosterone (TT), free testosterone (fT), sex hormone-binding globulin (SHBG) and bioavailability of testosterone (Bio-T)). There were 977 valid questionnaires. The LOH-positive rates shown by AMS and ADAM were 59.88% and 84.65%, respectively; values increased with the age of the patients. There were 946 results related to sex hormone measurements, which showed the following results: TT was not related to aging (P>0.05); levels of SHBG increased with age; and fT and Bio-T decreased with age. There was a significant difference in fT between LOH-positive and LOH-negative patients, as shown by the ADAM. In summary, TT levels were not related to aging, even though SHBG did increase while fT and Bio-T decreased with aging. Clinically, the diagnosis of LOH cannot be based on serum TT level.
Keywords: ADAM; AMS; late-onset of hypogonadism; male aging; old and middle-aged males; survey |
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