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Asian Journal of Andrology (2012) 14, 505-508; doi:10.1038/aja.2012.24; published online 16 April 2012
Clinical features and prognostic factors for patients with bone metastases from prostate cancer
Jian He, Zhao-Chong Zeng, Ping Yang, Bing Chen, We Jiang and Shi-Suo Du
Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Correspondence: Dr J He, (hejian62@163.com); Dr ZC Zeng, (zeng.zhaochong@zs-hospital.sh.cn)
Received 23 September 2011; Revised 22 December 2011; Accepted 10 February 2012
Advance online publication 16 April 2012.
| Abstract |
To identify the clinical features and independent predictors of survival in patients with bone metastases from prostate cancer (PCa). We retrospectively analysed 115 PCa patients with bone metastases between 1997 and 2009. The overall survival rate after bone metastases was calculated using the Kaplan–Meier method. The prognostic factors were identified by univariate analysis using a log-rank test and by multivariate analysis using Cox proportional hazards regression models. The follow-up rate was 100%, the follow-up cases during 1, 3 and 5 years were 103, 79 and 55, respectively. The 1-, 3- and 5-year survival rates were 89.1%, 60.9% and 49.8%, respectively, with a median survival time of 48.5 months for patients with bone metastases from PCa. In univariate analysis, age, Gleason score, clinical stage, the number of bone lesions, alkaline phosphatase (ALP) level, invasion of neighbouring organs and non-regional lymph node metastases were correlated with prognosis. By multivariate analysis using Cox regression, ALP level, Gleason score and non-regional lymph node metastases were independent prognostic factors. These prognostic factors will help us to determine the appropriate dose and fraction of radiotherapy for these patients.
Keywords: bone metastases; clinical features; prognostic analysis; prostate cancer |
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