|
Asian Journal of Andrology (2012) 14, 726–731; doi:10.1038/aja.2012.65; published online 20 August 2012
The risks, degree of malignancy and clinical progression of prostate cancer associated with the MDM2 T309G polymorphism: a meta-analysis
Jie Yang1,*, Wen Gao2,*, Ning-Hong Song1, Wei Wang1, Jie-Xiu Zhang1, Pei Lu1, Li-Xin Hua1 and Min Gu1
1 Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
2 Cancer Biotherapy Centre, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
Correspondence: Dr M Gu, (gumin6663300@163.com)
* These authors contributed equally to this work.
Received 31 March 2012; Revised 17 May 2012; Accepted 25 May 2012
Advance online publication 20 August 2012.
| Abstract |
To determine the risk, malignant degree and clinical progression of prostate cancer (PCa) associated with mouse double-minute 2 protein (MDM2) T309G variants, a meta-analysis was performed on all eligible published studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess these associations in seven studies that included 5151 cases and 1003 controls. In the overall analysis, the 309G allele was significantly associated with a decreased PCa risk (OR=0.85, 95% CI: 0.74–0.97); this was also the case for the homozygous comparison (OR=0.72, 95% CI: 0.55–0.95) and the dominant genetic model (OR=0.79, 95% CI: 0.65–0.96). The 309G allele was also found to be significantly associated with lower degrees of PCa malignancy (OR=0.85, 95% CI: 0.75–0.96) in the overall analysis, as well as in the heterozygous comparison (OR=0.79, 95% CI: 0.65–0.96), homozygous comparison (OR=0.76, 95% CI: 0.58–0.98) and dominant genetic model (OR=0.81, 95% CI: 0.68–0.96). Furthermore, grouping analysis showed that the 309G allele in Caucasians was significantly correlated with a decreased PCa risk (OR=0.77, 95% CI: 0.61–0.96); this was also the case in the homozygous comparison (OR=0.51, 95% CI: 0.31–0.86). The grouping analysis also showed that the 309G variant in Caucasians was significantly associated with a lower degree of PCa malignancy in all of the genetic models. In addition, we found that the 309G variant in Caucasians was significantly associated with a slower PCa clinical progression in all of the genetic models. In summary, our meta-analysis showed that the MDM2 309G variant was significantly associated with a decreased PCa risk, lower malignant degree and slower clinical progression in Caucasians, but there was no obvious association in the Asian population.
Keywords: clinical progression; malignant degree; MDM2; meta-analysis; polymorphism; prostate cancer; risk |
|
