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Asian Journal of Andrology (2012) 14, 870–874; doi:10.1038/aja.2012.48; published online 6 August 2012
Safety and efficacy of levofloxacin versus ciprofloxacin for the treatment of chronic bacterial prostatitis in Chinese patients
Zhi-Chao Zhang1, Feng-Shuo Jin2, Dong-Ming Liu3, Zhou-Jun Shen4, Ying-Hao Sun5 and Ying-Lu Guo1
1 Andrology Center, Peking University First Hospital, Institute of Urology, Peking University, Beijing 100034, China
2 Daping Hospital, Third Military Medical University, Chongqing 400042, China
3 Renji Hospital, Shanghai Jiaotong University, Shanghai 200001, China
4 Ruijin Hospital, Shanghai Jiaotong University, Shanghai 200025, China
5 Changhai Hospital, Second Military Medical University, Shanghai 200433, China
Correspondence: Dr ZC Zhang, (zhangzhichao@bjmu.edu.cn)
Received 19 October 2011; Revised 7 February 2012; Accepted 11 April 2012
Advance online publication 6 August 2012
| Abstract |
Levofloxacin is a synthetic fluoroquinolone that is usually used to treat chronic bacterial prostatitis. We investigated the safety and efficacy of levofloxacin compared with ciprofloxacin for the treatment of chronic bacterial prostatitis in Chinese patients. This was a multicenter, open-label, randomized controlled non-inferiority trial. Four hundred and seventy-one patients with clinical symptoms/signs were enrolled into the study, and 408 patients were microbiologically confirmed chronic bacterial prostatitis, who were randomized to either oral levofloxacin (500 mg q.d.) or ciprofloxacin (500 mg b.i.d.) for 4 weeks. Bacterial clearance rate, clinical symptoms/signs, adverse reactions and disease recurrence were assessed. The clinical symptoms and signs (including dysuria, perineal discomfort or pain) and bacteria cultures in 209 patients treated with levofloxacin and 199 patients treated with ciprofloxacin were similar. The most common bacteria were Escherichia coli and Staphylococcus aureus. One to four weeks after the end of 4 weeks treatment, the bacterial clearance rate (86.06% vs. 60.03%; P<0.05) and the clinical efficacy (including clinical cure and clinical improvement(93.30% vs. 71.86%; P<0.05)) were significantly higher in the levofloxacin-treated group than in the ciprofloxacin-treated group. The microbiological recurrence rate was significantly lower in the levofloxacin-treated group than in the ciprofloxacin-treated group (4.00% vs. 19.25%; P<0.05). Rates of adverse events and treatment-related adverse events were slightly lower in the levofloxacin-treated group than in ciprofloxacin-treated group. Levofloxacin showed some advantages over ciprofloxacin in terms of clinical efficacy and disease recurrence, with a low rate of adverse events, for the treatment of chronic bacterial prostatitis in Chinese patients.
Keywords: chronic bacterial prostatitis; ciprofloxacin; levofloxacin; recurrence |
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