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Abstract

Volume 18, Issue 6 (November 2016) 18, 920–924; 10.4103/1008-682X.173449

Preventive effects of β-cryptoxanthin against cadmium-induced oxidative stress in the rat testis

Xiao-Ran Liu1, Yue-Ying Wang1, Hai-Rui Fan1, Can-Jie Wu1, Ashok Kumar2, Li-Guo Yang1

1 Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China
    2 State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, China

Correspondence: Dr. LG Yang (yangliguo2006@qq.com)

Date of Submission 21-Apr-2015 Date of Decision 01-Jul-2015 Date of Acceptance 07-Dec-2015 Date of Web Publication 22-Apr-2016

Abstract

β-cryptoxanthin (CRY), a major carotenoid of potential interest for health, is obtained naturally from orange vegetables and fruits. A few research studies have reported that CRY could decrease oxidative stress and germ cell apoptosis. The purpose of this study was to examine the effects of CRY on acute cadmium chloride (CdCl 2 )-induced oxidative damage in rat testes. For this study, 24 rats were divided into four groups, one of which serves as a control group that received intraperitoneal (i.p.) injections of corn oil and physiological saline. The other rats were i.p. injected with CRY (10 μg kg−1 ) every 8 h, beginning 8 h before CdCl 2 (2.0 mg kg−1 ) treatment. The pathological and TUNEL findings revealed that CRY ameliorated the Cd-induced testicular histological changes and germ cell apoptosis in the rats. Furthermore, the Cd-induced decrease in the testicular testosterone (T) level was attenuated after CRY administration (P < 0.05). The administration of CRY significantly reversed the Cd-induced increases in the lipid peroxide (LPO) and malondialdehyde (MDA) levels (P < 0.01). The testicular antioxidants superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) were decreased by treatment with Cd alone but were restored by CRY co-treatment. These results demonstrated that the application of CRY can enhance the tolerance of rats to Cd-induced oxidative damage and suggest that it has promised as a pharmacological agent to protect against Cd-induced testicular toxicity.
    
    Keywords: apoptosis; cadmium chloride; cryptoxanthin; oxidative stress; rat; testicular damage; testosterone

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