Home  |  Archive  |  Online Submission  |  News & Events  |  Subscribe  |  APFA  |  Society  |  Links  |  Contact Us  |  中文版

Ahead of print
Authors' Accepted
Current Issue
Special Issues
Browse by Category

Manuscript Submission

Online Submission
Online Review
Instruction for Authors
Instruction for Reviewers
English Corner new!

About AJA

About AJA
Editorial Board
Contact Us

Resources & Services

Email alert

Download area

Copyright licence
EndNote style file
Manuscript word template
Guidance for AJA figures
    preparation (in English)

Guidance for AJA figures
    preparation (in Chinese)

Proof-reading for the

AJA Club (in English)
AJA Club (in Chinese)


Societies & Institutes
Databases & Libraries
Other links


Volume 19, Issue 6 (November 2017) 19, 639–646; 10.4103/1008-682X.186871

Impact of antioxidants on seminal vesicles function and fertilizing potential in diabetic rats

Panagiota Tsounapi1 , Masashi Honda1 , Fotios Dimitriadis2 , Bunya Kawamoto1 , Katsuya Hikita1 , Kuniyasu Muraoka1 , Motoaki Saito3 , Nikolaos Sofikitis2 , Atsushi Takenaka1

1 Division of Urology, Department of Surgery, Tottori University School of Medicine, 36-1 Nishimachi, Yonago 683-8503, Japan
2 Department of Urology, University of Ioannina, School of Medicine, P.O. Box 1186, 45110, Ioannina, Greece
3 Department of Pharmacology, Kochi University , Kochi Medical School, Nankoku, 783-8505, Japan

Correspondence: Dr. M Honda (honda@med.tottori-u.ac.jp)

Date of Submission 15-Mar-2016 Date of Decision 12-May-2016 Date of Acceptance 12-Jul-2016 Date of Web Publication 14-Oct-2016


Diabetes mellitus significantly affects the male reproduction and sexual function. In the present study, we investigated the diabetes-induced dysfunction of seminal vesicles (SVs) in the diabetes-rat model and the role of antioxidants. Streptozotocin-induced diabetes after 4 weeks caused smaller size of the organs, hypercontractility, histological abnormalities, increased concentrations of malondialdehyde in the serum and tissue, overexpression of oxidative stress markers, and cleaved caspase-3 as identified by immunohistochemistry in the SVs. In addition, diabetes resulted in deceased levels of serum testosterone and no newborns after the mating studies. Antioxidants significantly normalized all the above parameters, except for the severely decreased serum testosterone levels and the negative outcome of the mating studies. The present study gives evidence for the important role of diabetes-induced oxidative stress in the function and structure of these androgen-dependent organs. Antioxidants may be a promising supplementary therapy for diabetic male patients to alleviate ejaculatory disorders but alone is not efficient treatment for the mitigation of infertility.

Keywords: diabetes mellitus; male infertility; oxidative stress; seminal vesicles; seminiferous epithelium; smooth muscle cell contractions

Keywords: diabetes mellitus; male infertility; oxidative stress; seminal vesicles; seminiferous epithelium; smooth muscle cell contractions

Full Text | PDF |

Browse:  218
Copyright 1999-2017  Shanghai Materia Medica, Shanghai Jiao Tong University.  All rights reserved