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Volume 13, Issue 2 (March 2011) 13, 242–247; 10.1038/aja.2010.100
Somatostatin receptor subtypes in hormone-refractory (castration-resistant) prostatic carcinoma
Roberta Mazzucchelli1,*, Doriana Morichetti1,*, Marina Scarpelli1, Aldo V Bono1, Antonio Lopez-Beltran2, Liang Cheng3, Ziya Kirkali4 and Rodolfo Montironi1
1 Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona 60126, Italy
2 Department of Pathology, Reina Sofia University Hospital and Faculty of Medicine, Cordoba 14001, Spain
3 Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
4 Department of Urology, School of Medicine, Dokuz Eylül University, Izmir 35010, Turkey
* These authors contributed equally to this work.
Correspondence: Dr R Montironi, (r.montironi@univpm.it)
Received 26 May 2010; Revised 5 July 2010; Accepted 30 July 2010; Published online 13 December 2010
| Abstract |
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The aim of this study was to examine the tissue expression and localisation of the somatostatin receptors (SSTRs) in hormone-refractory (HR) prostate cancer (PCa). Five SSTRs were evaluated immunohistochemically in 20 radical prostatectomies (RPs) with Gleason score (GS) 3+3=6 PCa, in 20 RPs with GS 4+4=8 and 4+5=9 PCa, and 20 transurethral resection of the prostate specimens with HR PCa. The mean values in the cytoplasm (all five SSTRs were expressed), membrane (only SSTR3 and SSTR4 were expressed) and nuclei (only SSTR4 and SSTR5 were expressed) of the glands in HR PCa were 20–70% lower than in the other two groups, the differences being statistically significant. All five SSTRs were expressed in the smooth muscle and endothelial cells of HR PCa, the mean values being lower than in the other two groups. In conclusion, this study expands our knowledge on the expression and localisation of five SSTRs in the various tissue components in the HR PCa compared with hormone-sensitive PCa.
Keywords: hormone-refractory prostate cancer; prostate cancer progression; prostatic adenocarcinoma; somatostatin receptors
Keywords: hormone-refractory prostate cancer; prostate cancer progression; prostatic adenocarcinoma; somatostatin receptors
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