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Volume 15, Issue 1 (January 2013) 15, 149–151; 10.1038/aja.2012.125
Incidental seminal vesicle amyloidosis observed in diagnostic prostate biopsies--are routine investigations for systemic amyloidosis warranted?
Zichu Yang1, Alexander Laird2, Ashley Monaghan2, Morag Seywright3, Imran Ahmad2,4 and Hing Y Leung2,4
1 Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland G12 8QQ, UK
2 Department of Urology, Gartnavel General Hospital, NHS Great Glasgow and Clyde, Glasgow, Scotland G12 0YN, UK
3 Pathology NHSGGC, Southern General Hospital, Glasgow, Scotland G51 4TF, UK
4 The Beatson Institute for Cancer Research, Glasgow, Scotland G61 1BD, UK
Correspondence: Professor HY Leung, (h.leung@beatson.gla.ac.uk)
Received 7 September 2012; Revised 15 October 2012; Accepted 16 October 2012 Advance online publication 10 December 2012
| Abstract |
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Seminal vesicle (SV) amyloidosis is a well-documented histological entity, but it is observed infrequently. Its incidence is on the rise, which is probably related to the increasing use of prostate biopsies to investigate patients with elevated serum prostate-specific antigen levels. Here, we report seven cases of incidental SV amyloidosis over a 3-year period and consider their relationship to the previously suggested aetiological factors. Based on our series, we conclude that incidental localized SV amyloidosis observed in diagnostic prostate biopsies does not warrant formal investigations for systemic amyloidosis.
Keywords: accessory sex organs; male; prostate biopsies; prostate cancer; prostate diseases; prostatitis; seminal vesicle amyloidosis
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