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Volume 15, Issue 4 (July 2013) 15, 441–442; 10.1038/aja.2013.31
Screening and efficacy of radical prostatectomy
Michael Froehner
Department of Urology, University Hospital Carl Gustav Carus, Dresden University of Technology, Fetscherstrasse 74, Dresden D-01307, Germany
Correspondence: Dr M Froehner, (Michael.Froehner@uniklinikum-dresden.de)
advance online publication, April 15, 2013
| Abstract |
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In a recently published study, the results of the Prostate Cancer Intervention versus Observation Trial (PIVOT) trial were compared with that of the Scandinavian Prostate Cancer Group Study Number 4 (SPCG-4). The authors concluded that the discrepancy of the mortality rates between both studies may be explained by screen-related lead time and over-diagnosis. In this comment, some potential biases are discussed and the limited applicability of the results of both randomized trials to healthy candidates for radical prostatectomy is underlined.
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