Asian Journal of Andrology

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Abstract

Volume 15, Issue 4 (July 2013) 15, 449–450; 10.1038/aja.2013.63

A tight junction between E-Cadherin and the prostate tumor suppressor SPDEF

Valeria Coppola and Désirée Bonci

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome 00161, Italy

Correspondence: Dr V Coppola, (valeria.coppola@iss.it)

advance online publication, May 27, 2013

Abstract

Mounting evidence is highlighting the role of the ETS factor SPDEF as a prostate tumor suppressor. In a recent paper by Pal et al., SPDEF was found to transcriptionally control the expression of E-Cadherin, an adhesion molecule with a crucial role in preventing metastatic spread.

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