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Volume 11, Issue 1 (January 2009) 11, 127–130; 10.1038/aja.2008.16

Neoadjuvant hormonal deprivation for patients undergoing radical prostatectomy

Xu Gao*, Tie Zhou*, Yuan-Jie Tang, Xin Lu and Ying-Hao Sun

Department of Urology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China

* These authors contributed equally to this work.

Correspondence: Dr Ying-Hao Sun, Department of Urology, Changhai Hospital, The Second Military Medical University, 174 Changhai Road, Shanghai 200433, China. Fax: +86-21-6533-8288 E-mail: sunyh@medmail.com.cn

Received 28 September 2008; Accepted 2 October 2008; Published online 1 December 2008


The purpose of this study is to evaluate the therapeutic effect of radical prostatectomy combined with preoperative neoadjuvant hormonal ablation therapy for prostate cancer (PCa). In this study, a total of 31 patients with local PCa underwent radical prostatectomy; of these, 12 patients underwent preoperative hormonal deprivation with a combination of goserelin and flutamide for a period of 5.6 months. Data regarding clinical characteristics were compared between the neoadjuvant therapy and radical prostatectomy groups. A total of 31 patients received pelvic lymph node clearance, and the rate of positive lymph nodes was 12.9% (4/31). Serum prostate-specific antigen (PSA) was 8.9 1.2 g L-1 after the neoadjuvant therapy and 0.4 0.3 g L-1 one month after the radical prostatectomy. There were significant differences in the positive surgical margins, seminal vesicle invasion and lymph node metastasis between the neoadjuvant therapy group (n = 12) and the radical prostatectomy group (n = 19, P < 0.01). The resulsts indicates that preoperative hormonal deprivation induced by goserelin and flutamide can decrease clinical and pathological staging, but assessment of its influence on long-term prognosis requires further study.

Keywords: neoadjuvant therapy, prostate carcinoma, prostatectomy

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Asian Journal of Andrology CN 31-1795/R ISSN 1008-682X  Copyright © 2023  Shanghai Materia Medica, Chinese Academy of Sciences.  All rights reserved.