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Abstract

Volume 11, Issue 1 (January 2009) 11, 127–130; 10.1038/aja.2008.16

Neoadjuvant hormonal deprivation for patients undergoing radical prostatectomy

Xu Gao*, Tie Zhou*, Yuan-Jie Tang, Xin Lu and Ying-Hao Sun

Department of Urology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China

* These authors contributed equally to this work.

Correspondence: Dr Ying-Hao Sun, Department of Urology, Changhai Hospital, The Second Military Medical University, 174 Changhai Road, Shanghai 200433, China. Fax: +86-21-6533-8288 E-mail: sunyh@medmail.com.cn

Received 28 September 2008; Accepted 2 October 2008; Published online 1 December 2008

Abstract

The purpose of this study is to evaluate the therapeutic effect of radical prostatectomy combined with preoperative neoadjuvant hormonal ablation therapy for prostate cancer (PCa). In this study, a total of 31 patients with local PCa underwent radical prostatectomy; of these, 12 patients underwent preoperative hormonal deprivation with a combination of goserelin and flutamide for a period of 5.6 months. Data regarding clinical characteristics were compared between the neoadjuvant therapy and radical prostatectomy groups. A total of 31 patients received pelvic lymph node clearance, and the rate of positive lymph nodes was 12.9% (4/31). Serum prostate-specific antigen (PSA) was 8.9 1.2 g L-1 after the neoadjuvant therapy and 0.4 0.3 g L-1 one month after the radical prostatectomy. There were significant differences in the positive surgical margins, seminal vesicle invasion and lymph node metastasis between the neoadjuvant therapy group (n = 12) and the radical prostatectomy group (n = 19, P < 0.01). The resulsts indicates that preoperative hormonal deprivation induced by goserelin and flutamide can decrease clinical and pathological staging, but assessment of its influence on long-term prognosis requires further study.

Keywords: neoadjuvant therapy, prostate carcinoma, prostatectomy

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