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Abstract

Volume 11, Issue 1 (January 2009) 11, 57–67; 10.1038/aja.2008.29

Molecular mechanisms of metastasis in prostate cancer

Noel W. Clarke, Claire A. Hart and Mick D. Brown

Genito-Urinary Cancer Research Group, School of Cancer and Imaging Sciences, Paterson Institute for Cancer Research, Christie Hospital, University of Manchester, Manchester M20 4BX, UK

Correspondence: Dr Mick D. Brown, Genito-Urinary Cancer Research Group, School of Cancer and Imaging Sciences, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK. Fax: +44-16-1446-3109 E-mail: mbrown@picr.man.ac.uk

Received 10 October 2008; Accepted 11 October 2008; Published online 1 December 2008

Abstract

Prostate cancer (PCa) preferentially metastasizes to the bone marrow stroma of the axial skeleton. This activity is the principal cause of PCa morbidity and mortality. The exact mechanism of PCa metastasis is currently unknown, although considerable progress has been made in determining the key players in this process. In this review, we present the current understanding of the molecular processes driving PCa metastasis to the bone.

Keywords: bone, bone marrow stroma, metastasis, prostate cancer

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