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Abstract

Volume 13, Issue 3 (May 2011) 13, 476–480; 10.1038/aja.2010.143

Altered expression patterns of syndecan-1 and -2 predict biochemical recurrence in prostate cancer

Rodrigo Ledezma1, Federico Cifuentes1, Iván Gallegos2, Juan Fullá1, Enrique Ossandon3, Enrique A Castellon1 and Héctor R Contreras1

1 Laboratory of Molecular and Cellular Andrology, Physiology and Biophysics Program. Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago 70005, Chile
2 Pathology Service, Clinic Hospital, University of Chile, Santiago 70005, Chile
3 Urology Service, Clinic Hospital, University of Chile, Santiago 70005, Chile

Correspondence: Dr HR Contreras, (hcontrer@med.uchile.cl)

Received 12 April 2010; Revised 25 July 2010; Accepted 3 September 2010; Published online 14 February 2011

Abstract

The clinical features of prostate cancer do not provide an accurate determination of patients undergoing biochemical relapse and are therefore not suitable as indicators of prognosis for recurrence. New molecular markers are needed for proper pre-treatment risk stratification of patients. Our aim was to assess the value of altered expression of syndecan-1 and -2 as a marker for predicting biochemical relapse in patients with clinically localized prostate cancer treated by radical prostatectomy. The expression of syndecan-1 and -2 was examined by immunohistochemical staining in a series of 60 paraffin-embedded tissue samples from patients with localized prostate cancer. Ten specimens from patients with benign prostatic hyperplasia were used as non-malignant controls. Semiquantitative analysis was performed to evaluate the staining patterns. To investigate the prognostic value, Kaplan–Meier survival curves were performed and compared by a log-rank test. In benign samples, syndecan-1 was expressed in basal and secretory epithelial cells with basolateral membrane localisation, whereas syndecan-2 was expressed preferentially in basal cells. In prostate cancer samples, the expression patterns of both syndecans shifted to granular-cytoplasmic localisation. Survival analysis showed a significant difference (P<0.05) between normal and altered expression of syndecan-1 and -2 in free prostate-specific antigen recurrence survival curves. These data suggest that the expression of syndecan-1 and -2 can be used as a prognostic marker for patients with clinically localized prostate cancer, improving the prostate-specific antigen recurrence risk stratification.

Keywords: biochemical recurrence; prostate cancer; syndecans

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