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Abstract

Volume 13, Issue 2 (March 2011) 13, 231–235; 10.1038/aja.2010.162

Three important components in the regeneration of the cavernous nerve: brain-derived neurotrophic factor, vascular endothelial growth factor and the JAK/STAT signaling pathway

Hai-Yang Zhang1,2, Xun-Bo Jin1 and Tom F Lue2

1 Minimally Invasive Urology Center, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China
2 Knuppe Molecular Urology Laboratory, Department of Urology, University of California, San Francisco, CA 94143, USA

Correspondence: Dr TF Lue, (tlue@urology.ucsf.edu); Dr XB Jin, (JXB.SDU@hotmail.com)

Received 11 August 2010; Revised 24 September 2010; Accepted 26 October 2010; Published online 20 December 2010

Abstract

Retroperitoneal operations, such as radical prostatectomy, often damage the cavernous nerve, resulting in a high incidence of erectile dysfunction. Although improved nerve-sparing techniques have reduced the incidence of nerve injury, and the administration of phosphodiesterase type 5 inhibitors has revolutionized the treatment of erectile dysfunction, this problem remains a considerable challenge. In recent years, scientists have focused on brain-derived neurotrophic factor and vascular endothelial growth factor in the treatment of cavernous nerve injury in rat models. Results showed that both compounds were capable of enhancing the regeneration of the cavernous nerve and that activation of the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway played a major role in the process.

Keywords: brain-derived neurotrophic factor; erectile dysfunction; Janus kinase; signal transducer and activator of transcription; vascular endothelial growth factor

Keywords: brain-derived neurotrophic factor; erectile dysfunction; Janus kinase; signal transducer and activator of transcription; vascular endothelial growth factor

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