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Abstract

Volume 15, Issue 1 (January 2013) 15, 87–88; 10.1038/aja.2012.137

RABL-regulated pathways: a new tale in sperm function

Charles M Allan

ANZAC Research Institute, Concord Hospital, University of Sydney, Sydney, NSW 2139, Australia

Correspondence: Dr CM Allan, (charles@anzac.edu.au)

published online: 10 December 2012

Abstract

Mammalian sperm have a specialized motile flagellum to provide the unidirectional propulsion required to achieve fertilisation of the egg. Defective flagella development and/or function is a significant cause of reduced sperm motility (asthenospermia) and male infertility. Over the past decade, a growing number of distinct proteins with crucial roles in sperm flagella have been identified by genetic loss-of-function approaches in mice, in which the deliberately engineered or spontaneous mutation of individual genes have lead to anomalies in sperm tail assembly, structure and function. In a recent study published in PLoS Genetics, Lo et al. have utilized random mutagenesis induced by the chemical mutagen N-ethyl-nitrosourea to identify a previously uncharacterized protein (RABL2) in murine sperm flagella required for male fertility.

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Asian Journal of Andrology CN 31-1795/R ISSN 1008-682X  Copyright © 2023  Shanghai Materia Medica, Chinese Academy of Sciences.  All rights reserved.