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Volume 15, Issue 4 (July 2013) 15, 497–502; 10.1038/aja.2012.174

Efficacy and safety of local anaesthetics for premature ejaculation: a systematic review and meta-analysis

Jia-Dong Xia1, You-Feng Han1, Liu-Hua Zhou2, Yun Chen1,2 and Yu-Tian Dai1,2

1 Division of Andrology, Nanjing Drum Tower Hospital, Nanjing Medical University, Nanjing 210008, China
2 Division of Andrology, The Affiliated Drum Tower Hospital of Nanjing University, School of Medicine, Nanjing 210008, China

Correspondence: Dr YT Dai, (ytdai@hotmail.com); Dr Y Chen, (chenyunnju@hotmail.com)

Received 12 October 2012; Revised 29 November 2012; Accepted 8 January 2013; Advance online publication 27 May 2013


To assess the efficacy and safety of local anaesthetics for premature ejaculation (PE), a systematic review of the literature was performed using the Cochrane Library, PUBMED and EMBASE. We screened and retrieved the randomized controlled trials on the treatment of PE with local anaesthetics. End points included intravaginal ejaculation latency time (IELT), patient-reported outcome assessments and adverse events. Meta-analyses were conducted with Stata 11.0. In total, seven publications involving 566 patients with local anaesthetics and 388 with placebos strictly met our eligibility criteria. Meta-analyses showed that after the patients were treated with the local anaesthetics, the value of the standardized mean difference of the changes in IELT was 5.02 (95% CI: 3.03–7.00). A higher rate of adverse events occurred compared with placebos (odds ratio: 3.30, 95% CI: 1.71–6.36), but these events were restricted to local side effects. In addition, significantly greater improvement was observed in patient-reported outcomes. In summary, local anaesthetics can prolong IELT and improve ejaculatory control and sexual satisfaction.

local anaesthetics; premature ejaculation (PE); randomized controlled trial; systematic review

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Asian Journal of Andrology CN 31-1795/R ISSN 1008-682X  Copyright © 2023  Shanghai Materia Medica, Chinese Academy of Sciences.  All rights reserved.