Aim: To investigate the transforming growth factor β ₁ (TGF-β₁) and basic fibroblast growth factor (bFGF) expressions in benign prostatic hyperplasia (BPH) and the effect of β-radiation.

Methods: TGF-β ₁ and bFGF expression was studied by means of an immunohistochemical method in nine normal prostatic (NP) tissues, 15 hyperplastic prostatic tissues and 35 hyperplastic prostatic tissues treated with ⁹⁰Sr/⁹⁰Y.

Results: The TGF-β ₁ expression in the epithelium and stroma of normal prostatic tissues was 68.2 %+/-10.5 % and 29.7 %+/-4.6 %, respectively, while it was 64.8 %+/-9.3 % and 28.6 %+/-4.1 %, respectively, in hyperplastic prostatic tissues. Compared with the controls, TGF-β₁ expression in the epithelia and stroma of BPH treated with ⁹⁰Sr/⁹⁰Y increased significantly (P < 0.01). The bFGF expression in epithelia and stroma of normal prostatic tissues was 17.4 %+/-3.7 % and 42.5 %+/-6.8 %, respectively, and was 46.3 %+/-8.2 % and 73.2 %+/-12.1 %, respectivley, in hyperplastic prostatic tissues. Compared with the controls, expressions of bFGF in the epithelia and stroma of BPH treated with a ⁹⁰Sr/⁹⁰Y prostatic hyperplasia applicator decreased significantly (P < 0.01).

Conclusion: Exposure of β-rays had noticeable effects on BPH tissues, enhancing TGF-β₁ expression and inhibiting bFGF expression.

Keywords: benign prostatic hyperplasia, radiation, transforming growth factor β ₁, basic fibroblast growth factor

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