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Volume 8, Issue 1 (January 2006) 8, 11–29; 10.1111/j.1745-7262.2006.00112.x
Sperm chromatin structure and male fertility: biological and clinical aspects
J Erenpreiss, M Spano, J Erenpreisa, M Bungum and A Giwercman
1.University of Lund, Fertility Centre, Malmö University Hospital, Malmö SE 205 02, Sweden
2.Latvian University Biomedicine Centre, Ratsupites 1, Riga LV 1067, Latvia
3.Section of Toxicology and Biomedical Sciences, BIOTEC-MED, ENEA CR Casaccia, Via Anguillarese 301, Rome 00060, Italy
4.Fertility Clinic, Viborg Hospital (Skive), Resenvej 25, DK 7800 Skive, Denmark
Correspondence: Dr Juris Erenpreiss, Fertility Centre, Malmö University Hospital, Malmö SE 205 02 Sweden. Fax: +46-4033-7043. E-mail: Juris.Erenpreiss@med.lu.se
Received 18 April 2005; Accepted 12 November 2005
| Abstract |
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Aim: Sperm chromatin/DNA integrity is essential for the accurate transmission of paternal genetic information, and normal sperm chromatin structure is important for sperm fertilizing ability. The routine examination of semen, which includes sperm concentration, motility and morphology, does not identify defects in sperm chromatin structure. The origin of sperm DNA damage and a variety of methods for its assessment are described. Evaluation of sperm DNA damage appears to be a useful tool for assessing male fertility potential both in vivo and in vitro. The possible impact of sperm DNA defects on the offspring is also discussed.
Keywords: infertility, sperm, DNA damage, human
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