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Volume 8, Issue 6 (November 2006) 8, 725–729; 10.1111/j.1745-7262.2006.00204.x
Testosterone decreases adiponectin levels in female to male transsexuals
Marta Berra1, Francesca Armillotta1, Laura D Emidio1, Antonietta Costantino1, Giuseppe Martorana2, Giuseppe Pelusi1 and Maria Cristina Meriggiola1
1Department of Obstetrics and Gynecology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna 40138, Italy
2Department of Urology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna 40138, Italy
Correspondence: Dr Maria Cristina Meriggiola, Department of Obstetrics and Gynecology, S. Orsola Hospital, Via Massarenti 13, Bologna 40138, Italy. Fax: +39-051-636-3716. E-mail: cristina.meriggiola@unibo.it
Received 31 March 2006; Accepted 2 June 2006.
| Abstract |
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Aim: To evaluate the effect of testosterone (T) on adiponectin serum levels in transsexual female patients.
Methods: We measured adiponectin, leptin, luteinizing hormone and follicle stimulating hormone, T, estradiol, lipid profile, biochemical parameters and body composition in 16 transsexual female patients at baseline and after 6 months of T treatment (100 mg Testoviron Depot /10 days, i.m.).
Results: Adiponectin levels were 16.9 ± 7.3 mg/mL at baseline and 13.5± 7.4 mg/mL at month 6 of T treatment (P < 0.05). Leptin and high-density lipoprotein cholesterol decreased significantly, whereas body mass index, waist circumference and lean body mass increased significantly after 6 months of T treatment. No changes in insulin or Homeostasis Model Assessment were detected.
Conclusion: T can significantly reduce adiponectin serum levels in transsexual female patients.
Keywords: adiponectin, testosterone, transsexualism
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