Aim: To evaluate the effects of metabolic profiles on lower urinary tract symptoms (LUTS) in men with erectile dysfunction (ED).

Methods: A total of 75 impotent men aged 25–75 years old (mean 58.1 years) were included in the study on a prospective basis. Patients were evaluated with a complete history, physical examination, anthropometry and metabolic profiles. LUTS were assessed using the International Prostate Symptom Score (IPSS).

Results: Overall, there was no correlation between the IPSS and continuous parameters. However, when continuous variables were categorized, some parameters were significantly associated with LUTS. Patients with triglyceride level of 150 mg/dL or higher had more severe symptoms than those with tiglyceride levels less than 150 mg/dL (19.4 2.4 vs. 14.3 1.1, P = 0.033). When 40 mg/dL was chosen as the high-density lipoprotein (HDL)-cholesterol cut-off level, the IPSS was significantly different between the two groups divided by 40 mg/dL (19.4 2.6 for HDL-cholesterol < 40 mg/dL vs. 14.4 1.0 for HDL-cholesterol 40 mg/dL, P = 0.042). The area under the receiver operating characteristic curve (AUROCC) of triglyceride was 65.7% (95% confidence interval [CI], 52.6%-82.3%; P = 0.034) for severe LUTS. However, the AUROCC for 'HDL-cholesterol' was not significant (area, 65.4%; 95% CI, 48.2%–82.7%; P = 0.062). No other factors were determined to be significant in this regard.

Conclusion: The results of the present study indicate that some metabolic profiles might influence LUTS in men with ED.

Keywords: lower urinary tract symptoms, erectile dysfunction, metabolic syndrome, body mass index, testosterone

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