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Volume 9, Issue 5 (September 2007) 9, 659–667; 10.1111/j.1745-7262.2007.00288.x
17beta-estradiol stimulates proliferation of spermatogonia in experimental cryptorchid mice
En-Zhong Li, De-Xue Li, Shi-Qing Zhang, Chang-Yong Wang, Xue-Ming Zhang, Jing-Yan Lu, Cui-Mi Duan, Xiang-Zhong Yang and Li-Xin Feng
1.Beijing Institute of Basic Medical Sciences, Beijing 100850, China
2.Department of Agriculture and Forestry, Huanghuai University, Zhumadian 463000, China
3.College of Animal Sciences and Veterinary Medicine, Jilin University, Changchun 130002, China
4.Department of Animal Science and Center for Regenerative Biology, University of Connecticut, Storrs, Connecticut 06269-4243, USA
Correspondence: Dr De-Xue Li, Office of Beijing Academy of Medical Sciences, 27 Taiping Road, Beijing 100850, China. Fax: +86-10-6693-0055. E-mail: lidx@nic.bmi.ac.cn
Received 15 August 2006; Accepted 5 April 2007.
| Abstract |
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Aim: To investigate whether estrogen stimulates the proliferation of spermatogonia or induces spermatogenesis in cryptorchid mice.
Methods: Mice were surgically rendered cryptorchid, then treated with different doses of 17-estradiol (E2) s.c. once a day. Mice were killed at sexual maturity (45 days of age), and histological analysis and immunofluorescence were performed. Serum follicle stimulating hormone (FSH), estradiol, testosterone and luteinizing hormone (LH) were measured.
Results: Low doses of E2 had no notable effect on spermatogonia, but at higher doses, E2 stimulated the proliferation of spermatogonia.
Conclusion: E2 has a dose-related mitogenic effect on spermatogonia.
Keywords: 17-estradiol, cryptorchid mice, proliferation, spermatogonia
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