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Volume 10, Issue 2 (March 2008) 10, 332–336; 10.1111/j.1745-7262.2008.00248.x
Clinical pregnancies and livebirths achieved by intracytoplasmic injection of round headed acrosomeless spermatozoa with and without oocyte activation in familial globozoospermia: case report
Enver K Dirican, Ahmet Isik, Kubilay Vicdan, Eran Sozen and Zekiye Suludere
Department of Embryology, Private Ankara IVF Center, Ankara 06460, Turkey
Correspondence: Dr Enver K Dirican, Department of Embryology, Private Ankara IVF Center, Ankara 06460, Turkey. Fax: +90-312-472-3338. E-mail: kerem@dirican.tr.tc
Received 20 September 2006; Accepted 6 November 2006.
| Abstract |
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We report the successful outcome of intracytoplasmic sperm injection (ICSI) treatment in two siblings with familial globozoospermia. After controlled ovarian hyperstimulation and oocyte pick-up, retrieved oocytes were mechanically activated before ICSI and a fertilization rate of 33.3% was achieved in the first case. The second couple underwent ICSI without oocyte activation and a 9.1% fertilization rate was obtained. The transfer of two grade I embryos in the first couple and one grade I embryo in the second couple resulted in clinical pregnancies with healthy livebirths. It was concluded that the main problem of cases with globozoospermia is a low fertilization rate, and even though ICSI and oocyte activation can increase this rate it is not necessarily needed to achieve a pregnancy.
Keywords: intracytoplasmic sperm injection, spermatozoa, acrosome, scanning electron microscopy
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