Home  |   Archive  |   Online Submission  |   News & Events  |   Subscribe  |   APFA  |   Society  |   Contact Us  |   中文版
Search   
 
Journal

Ahead of print
Authors' Accepted
    Manuscripts
new!
Current Issue
Archive
Acknowledgments
Special Issues
Browse by Category

Manuscript Submission

Online Submission
Online Review
Instruction for Authors
Instruction for Reviewers
English Corner new!

About AJA

About AJA
Editorial Board
Contact Us
News

Resources & Services

Advertisement
Subscription
Email alert
Proceedings
Reprints

Download area

Copyright licence
EndNote style file
Manuscript word template
Guidance for AJA figures
    preparation (in English)

Guidance for AJA figures
    preparation (in Chinese)

Proof-reading for the
    authors

AJA Club (in English)
AJA Club (in Chinese)

 
Abstract

Volume 7, Issue 4 (July 2005) 7, 405–410; 10.1111/j.1745-7262.2005.00051.x

Antispermatogenic activity of Morinda lucida extract in male rats

Yinusa Raji, Olumide S Akinsomisoye and Toyin M Salman

1.Department of Physiology, College of Medicine, University of Ibadan, Ibadan, Nigeria
2.Department of Physiological Sciences, Faculty of Basic Medical Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria

Correspondence: Dr Yinusa Raji, Department of Physiology, College of Medicine, University of Ibadan, Ibadan, Nigeria. Tel: +234-802-326-3626 E-mail: raji-ui@yahoo.com

Received: 2004-09-11 Accepted: 2005-03-21

Abstract

Aim: To investigate the effect of Morinda lucida Benth (Rubiaceae) on the reproductive activity of male albino rats.

Methods: Two groups of rats were treated with 400 mg/(kgd) of Morinda lucida leaf extract for 4 and 13 weeks, respectively. The control rats received the vehicle. All the treated rats had corresponding recovery groups. At the end of each experimental period, animals were killed and organ weights, sperm characteristics, serum testosterone levels, histology of the testes and fertility were assessed.

Results: Morinda lucida leaf extract did not cause any changes in body and somatic organ weights, but significantly increased the testis weight (P < 0.05). The sperm motility and viability, and the epididymal sperm counts of rats treated for 13 weeks were significantly reduced (P < 0.05). Sperm morphological abnormalities and serum testosterone levels were significantly increased (P < 0.05). There were various degrees of damage to the seminiferous tubules. The extract reduced the fertility of the treated rats by reducing the litter size. Reversal of these changes, however, occurred after a period of time.

Conclusion: The extract of Morinda lucida has reversible antispermatogenic properties.

Keywords: Morinda lucida, sperm, fertility, testosterone, antispermatogenic agents

Full Text | PDF |

 
Browse:  3814
 
Asian Journal of Andrology CN 31-1795/R ISSN 1008-682X  Copyright © 2023  Shanghai Materia Medica, Chinese Academy of Sciences.  All rights reserved.