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Volume 7, Issue 4 (July 2005) 7, 419–425; 10.1111/j.1745-7262.2005.00068.x

Significant reduction of sperm disomy in six men: effect of traditional Chinese medicine?

Helen G Tempest, Sheryl T Homa, Xiao-Ping Zhai and Darren K Griffin

1.Department of Biosciences, University of Kent, Canterbury CT2 7NJ, UK
2.Ten Harley Street, London W1G 9PF, UK

Correspondence: Dr Darren K. Griffin, Department of Biosciences, University of Kent, Canterbury CT2 7NJ, UK. Tel: +44-1227-823022, Fax: +44-1227-763-912 E-mail: d.k.griffin@kent.ac.uk

Received: 2005-02-02 Accepted: 2005-07-06


Aim: To test the hypothesis that levels of sperm disomy fell significantly in six men treated by traditional Chinese medicine (TCM).

Methods: Fluorescence in situ hybridization (FISH) was done on the sperm heads of six men before and during treatment by TCM.

Results: There was a significant reduction in sperm disomy in all six men. This coincided with TCM treatment.

Conclusion: This is the first study reporting a significant reduction in sperm disomy in men over a given time course. The fact that this coincided with TCM treatment is intriguing but no conclusions can be drawn from this until placebo-controlled clinical trials are implemented.

Keywords: traditional Chinese medicine, sperm disomy, chromosome, male infertility

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