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Volume 8, Issue 2 (March 2006) 8, 177–182; 10.1111/j.1745-7262.2006.00076.x

Beneficial effects of switching from -blockers to nebivolol on the erectile function of hypertensive patients

Michael Doumas, Alexandros Tsakiris, Stella Douma, Alkiviadis Grigorakis, Angelos Papadopoulos, Athina Hounta, Sotirios Tsiodras, Dimitrios Dimitriou and Helen Giamarellou

1.Hypertension Outpatient Clinic, Fourth Department of Internal Medicine, University of Athens, Attikon Hospital, Athens 12461, Greece
2.Urologic Outpatient Clinic, Second Department of Urology, University of Athens, Attikon Hospital, Athens 12461, Greece

Correspondence: Dr Michael Doumas, First Department of Internal Medicine, Academic Hospital of Alexandroupolis, 68100 Alexandroupolis, Greece. Fax: +30-255-103-0450. E-mail: michalisdoumas@yahoo.co.uk

Received 20 December 2004; Accepted 23 June 2005.


Aim: To investigate the effect of substituting -blockers with nebivolol on the erectile function of patients suffering from essential hypertension.

Methods: Forty-four young and middle-aged men (31–65 years) with essential hypertension visited our outpatient clinic and took -blocker treatment (atenolol, metoprolol or bisoprolol) for more than 6 months. All the patients completed a questionnaire regarding erectile function (International Index for Erectile Function). Patients were then switched to an equipotent dose of nebivolol for 3 months and, at the end of this time period, filled out the same questionnaire.

Results: Twenty-nine out of the 44 (65.9%) patients who took -blockers (atenolol, metoprolol or bisoprolol) had exhibited erectile dysfunction (ED). Their systolic and diastolic blood pressure did not change significantly with the treatment switch. In 20 out of these 29 (69%) patients, a significant improvement in the erectile function score was exhibited after 3 months of nebivolol administration, and in 11 of these 20 patients, erectile function was normalized.

Conclusion: Nebivolol seems to have a beneficial effect on ED (possibly due to increased nitric oxide availability); however, further prospective, randomized, placebo-controlled studies are needed to confirm the beneficial effects of nebivolol.

Keywords: erectile dysfunction, essential hypertension, -blockers, nebivolol

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