Home  |   Archive  |   Online Submission  |   News & Events  |   Subscribe  |   APFA  |   Society  |   Contact Us  |   中文版

Ahead of print
Authors' Accepted
Current Issue
Special Issues
Browse by Category

Manuscript Submission

Online Submission
Online Review
Instruction for Authors
Instruction for Reviewers
English Corner new!

About AJA

About AJA
Editorial Board
Contact Us

Resources & Services

Email alert

Download area

Copyright licence
EndNote style file
Manuscript word template
Guidance for AJA figures
    preparation (in English)

Guidance for AJA figures
    preparation (in Chinese)

Proof-reading for the

AJA Club (in English)
AJA Club (in Chinese)


Volume 8, Issue 5 (September 2006) 8, 584–588; 10.1111/j.1745-7262.2006.00198.x

The protective effect of vitamin E against oxidative damage caused by formaldehyde in the testes of adult rats

Dang-Xia Zhou, Shu-Dong Qiu, Jie Zhang, Hong Tian and Hai-Xue Wang

1.Research Center of Reproductive Medicine, Xi an Jiaotong University, Xi an 710061, China
2.Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi an 710061, China

Correspondence: Dr Shu-Dong Qiu, Research Center of Reproductive Medicine, School of Medicine, Xi an Jiaotong University, Xi an 710061, China. Fax: +86-29-8265-5180. E-mail: linpu8@sohu.com

Received 25 February 2006; Accepted 20 April 2006.


Aim: To investigate the effect of formaldehyde (FA) on testes and the protective effect of vitamin E (VE) against oxidative damage by FA in the testes of adult rats.

Methods: Thirty rats were randomly divided into three groups: (1) control; (2) FA treatment group (FAt); and (3) FAt + VE group. FAt and FAt + VE groups were exposed to FA by inhalation at a concentration of 10 mg/m3 for 2 weeks. In addition, FAt + VE group were orally administered VE during the 2-week FA treatment. After the treatment, the histopathological and biochemical changes in testes, as well as the quantity and quality of sperm, were observed.

Results: The testicular weight, the quantity and quality of sperm, the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and glutathione (GSH) were significantly decreased whereas the level of malondialdehyde (MDA) was significantly increased in testes of rats in FAt group compared with those in the control group. VE treatment restored these parameters in FAt + VE group. In addition, microscopy with hematoxylin-eosin (HE) staining showed that seminiferous tubules atrophied, seminiferous epithelial cells disintegrated and shed in rats in FAt group and VE treatment significantly improved the testicular structure in FAt + VE group.

Conclusion: FA destroys the testicular structure and function in adult rats by inducing oxidative stress, and this damage could be partially reversed by VE.

Keywords: formaldehyde, vitamin E, testis, rats, oxidative stress, reproductive toxicity

Full Text | PDF | 中文摘要 |

Browse:  3895
Asian Journal of Andrology CN 31-1795/R ISSN 1008-682X  Copyright © 2023  Shanghai Materia Medica, Chinese Academy of Sciences.  All rights reserved.