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Abstract

Volume 9, Issue 2 (March 2007) 9, 265–270; 10.1111/j.1745-7262.2007.00252.x

Seminal plasma anti-Müllerian hormone level correlates with semen parameters but does not predict success of testicular sperm extraction (TESE)

Taymour Mostafa, Medhat K Amer, Guirgis Abdel-Malak, Taha Abdel Nsser, Wael Zohdy, Shedeed Ashour, Dina El-Gayar and Hosam H Awad

1.Andrology & Sexology Department, Faculty of Medicine, Cairo University, Cairo 11553, Egypt
2.Adam International Clinic, Mohandesseen, Giza 12411, Egypt
3.Artificial Insemination and Embryo Transfer Department, Reproductive Research Institute, Alharam, Giza 12111, Egypt
4.Chemical Pathology Department, Faculty of Medicine, Cairo University, Cairo 11553, Egypt

Correspondence: Dr Taymour Mostafa, Andrology & Sexology Deptment, Faculty of Medicine, Cairo University, Cairo 11553, Egypt. Fax: +20-2363-2297. E-mail: taymour1155@link.net

Received 8 April 2006; Accepted 6 November 2006.

Abstract

Aim: To assess seminal plasma anti-Müllerian hormone (AMH) level relationships in fertile and infertile males.

Methods: Eighty-four male cases were studied and divided into four groups: fertile normozoospermia (n = 16), oligoasthenoteratozoospermia (n = 15), obstructive azoospermia (OA) (n = 13) and non-obstructive azoospermia (NOA) (n = 40). Conventional semen analysis was done for all cases. Testicular biopsy was done with histopathology and fresh tissue examination for testicular sperm extraction (TESE) in NOA cases. NOA group was subdivided according to TESE results into unsuccessful TESE (n = 19) and successful TESE (n = 21). Seminal plasma AMH was estimated by enzyme linked immunosorbent assay (ELISA) and serum follicular stimulating hormone (FSH) was estimated in NOA cases only by radioimmunoassay (RIA).

Results: Mean seminal AMH was significantly higher in fertile group than in oligoasthenoteratozoospermia with significance (41.5 10.9 pmol/L vs. 30.5 10.3 pmol/L, P < 0.05). Seminal AMH was not detected in any OA patients. Seminal AMH was correlated positively with testicular volume (r = 0.329, P = 0.005), sperm count (r = 0.483, P = 0.007), sperm motility percent (r = 0.419, P = 0.021) and negatively with sperm abnormal forms percent (r = -0.413, P = 0.023). Nonsignificant correlation was evident with age (r = -0.155, P = 0.414) and plasma FSH (r = -0.014, P = 0.943). In NOA cases, seminal AMH was detectable in 23/40 cases, 14 of them were successful TESE (57.5%) and was undetectable in 17/40 cases, 10 of them were unsuccessful TESE (58.2%).

Conclusion: Seminal plasma AMH is an absolute testicular marker being absent in all OA cases. However, seminal AMH has a poor predictability for successful testicular sperm retrieval in NOA cases.

Keywords: seminal plasma, anti-Müllerian hormone, spermatogenesis, azoospermia, testicular sperm extraction

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