Home  |  Archive  |  Online Submission  |  News & Events  |  Subscribe  |  APFA  |  Society  |  Links  |  Contact Us  |  中文版

Ahead of print
Authors' Accepted
Current Issue
Special Issues
Browse by Category

Manuscript Submission

Online Submission
Online Review
Instruction for Authors
Instruction for Reviewers
English Corner new!

About AJA

About AJA
Editorial Board
Contact Us

Resources & Services

Email alert

Download area

Copyright licence
EndNote style file
Manuscript word template
Guidance for AJA figures
    preparation (in English)

Guidance for AJA figures
    preparation (in Chinese)

Proof-reading for the

AJA Club (in English)
AJA Club (in Chinese)


Societies & Institutes
Databases & Libraries
Other links


Volume 9, Issue 4 (July 2007) 9, 445–452; 10.1111/j.1745-7262.2007.00307.x

Protein phosphatase PP12 in sperm morphogenesis and epididymal initiation of sperm motility

Rumela Chakrabarti, Lina Cheng, Pawan Puri, David Soler and Srinivasan Vijayaraghavan

Department of Biological Sciences, Kent State University, Kent, OH 44242-0001, USA

Correspondence: Dr Srinivasan Vijayaraghavan, Department of Biological Sciences, Kent State University, Kent, OH 44242-0001, USA. Fax: +1-330-672-3713. E-mail: svijayar@kent.edu


The serine/threonine phosphatase (PP1) isoform PP12, predominantly expressed in the testis, is a key enzyme in spermatozoa. High PP12 catalytic activity holds motility in check in immature spermatozoa. Inhibition of PP12 causes motility initiation in immature spermatozoa and motility stimulation and changes in flagellar beat parameters in mature spermatozoa. The PP12 isoform is present in all mammalian spermatozoa studied: mouse, rat, hamster, bovine, non-human primate and man. We have now identified at least four of its regulatory proteins that regulate distinct pools of PP12 within spermatozoa. Our studies provide new insights into biochemical mechanisms underlying development and regulation of sperm motility. We hypothesize that changes in sperm PP12 activity as a result of phosphorylation and reversible binding of the regulatory proteins to the catalytic subunit are critical in the development and regulation of motility and the ability of sperm to fertilize eggs. Targeted disruption of the Ppp1cc gene, which encodes the PP11 or PP12 isoforms, causes male infertility in mice as a result of impaired spermiogenesis. Our observations suggest that, in addition to motility, the protein phosphatase PP12 might play an isoform-specific function in the development of specialized flagellar structures of mammalian spermatozoa.

Keywords: protein phosphatase, epididymis, sperm motility, spermatogenesis

Full Text | PDF | 中文摘要 |

Browse:  3017
Copyright 1999-2017  Shanghai Materia Medica, Shanghai Jiao Tong University.  All rights reserved