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Volume 10, Issue 2 (March 2008) 10, 266–270; 10.1111/j.1745-7262.2008.00347.x
Genetic polymorphism of glutathione S-transferase T1 gene and susceptibility to idiopathic azoospermia or oligospermia in northwestern China
Qi-Fei Wu, Jun-Ping Xing, Kai-Fa Tang, Wei Xue, Min Liu, Jian-Hua Sun, Xin-Yang Wang and Xiao-Juan Jin
1.Department of Urology, First Affiliated Hospital, School of Medicine, Xi an Jiaotong University, Xi an 710004, China
2.Imaging Center, Second Affliated Hospital, School of Medicine, Xi an Jiaotong University, Xi an 710004, China
Correspondence: Dr Jun-Ping Xing, Department of Urology, First Affiliated Hospital, School of Medicine, Xi an Jiaotong University, Xi an 710061, China. Fax: +86-29-8526-3190. E-mail: xingjpcn@yahoo.com.cn
Received 16 May 2007; Accepted 23 August 2007.
| Abstract |
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Aim: To investigate the association of glutathione S-transferase T1 (GSTT1) gene polymorphism in patients with idiopathic azoospermia or oligospermia in the northwestern China population.
Methods: In the case-control study, GSTT1 genotypes were identified by multiplex polymerase chain reaction (PCR) with peripheral blood DNA samples from 78 patients with idiopathic azoospermia, 103 patients with idiopathic oligospermia and 156 age-matched controls with normal sperm concentration and motility, according to the criteria adapted from World Health Organization guidelines. All of the patients and controls were from northwestern China.
Results: There is a significant association between GSTT1 null genotype with idiopathic azoospermia risk (odds ratio [OR]: 2.36, 95% confidence interval [CI]: 1.33-4.20, P = 0.003) or idiopathic oligospermia risk (OR: 2.00, 95% CI: 1.17-3.27, P = 0.010).
Conclusion: GSTT1 null genotype is a predisposing risk factor for sporadic idiopathic azoospermia or oligospermia in northwestern China.
Keywords: glutathione S-transferase T1, genetic polymorphism, azoospermia, oligospermia, male infertility
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