Home  |  Archive  |  Online Submission  |  News & Events  |  Subscribe  |  APFA  |  Society  |  Links  |  Contact Us  |  中文版
Search
 
Journal

Ahead of print
Authors' Accepted
    Manuscripts
new!
Current Issue
Archive
Acknowledgments
Special Issues
Browse by Category

Manuscript Submission

Online Submission
Online Review
Instruction for Authors
Instruction for Reviewers
English Corner new!

About AJA

About AJA
Editorial Board
Contact Us
News

Resources & Services

Advertisement
Subscription
Email alert
Proceedings
Reprints

Download area

Copyright licence
EndNote style file
Manuscript word template
Guidance for AJA figures
    preparation (in English)

Guidance for AJA figures
    preparation (in Chinese)

Proof-reading for the
    authors

AJA Club (in English)
AJA Club (in Chinese)

Links

Meetings
Journals
Societies & Institutes
Hospitals
Databases & Libraries
Companies
Websites
Other links

 
Abstract

Volume 10, Issue 5 (September 2008) 10, 777–785; 10.1111/j.1745-7262.2008.00361.x

Randomized clinical trial of an ethanol extract of Ganoderma lucidum in men with lower urinary tract symptoms

Masanori Noguchi1, Tatsuyuki Kakuma2, Katsuro Tomiyasu1, Akira Yamada3, Kyogo Itoh3, Fumiko Konishi4, Shoichiro Kumamoto4, Kuniyoshi Shimizu5, Ryuichiro Kondo5 and Kei Matsuoka1

1 Department of Urology, Kurume University School of Medicine, Kurume 830-0011, Japan
2 Department of Bio-statistics, Kurume University School of Medicine, Kurume 830-0011, Japan
3 Department of Immunology, Kurume University School of Medicine, Kurume 830-0011, Japan
4 Research Laboratories, Chlorella Industry Co Ltd, Chikugo 833-0056, Japan
5 Department of Forest and Forest Products Science, Faculty of Agriculture, Kyushu University, Fukuoka 812-8582, Japan

Correspondence: Masanori Noguchi, M.D., Ph.D., Department of Urology, Kurume University School of Medicine, 67 Asahimachi, Kurume 830-0011, Japan. Fax: +81-942-34-2605. E-mail: noguchi@med.kurume-u.ac.jp

Received 25 September 2007; Accepted 26 October 2007

Abstract

Aim: To evaluate the safety and efficacy of an extract of Ganoderma lucidum that shows the strongest 5α-reductase inhibitory activity among the extracts of 19 edible and medicinal mushrooms by a double-blind, placebo-controlled, randomized and dose-ranging study in men with lower urinary tract symptoms (LUTS).

Methods: In this trial, we randomly assigned 88 men over the age of 49 years who had slight-to-moderate LUTS to 12 weeks of treatment with G. lucidum extract (6 mg once a day) or placebo. The primary outcome measures were changes in the International Prostate Symptom Score (IPSS) and variables of uroflowmetry. Secondary outcome measures included changes in prostate size, residual urinary volume after voiding, laboratory values and the reported adverse effects.

Results: G. lucidum was effective and significantly superior to placebo for improving total IPSS with 2.1 points decreasing at the end of treatment (mean difference, −1.18 points; 95% confidence interval, −1.74 to −0.62; P < 0.0001). No changes were observed with respect to quality of life scores, peak urinary flow, mean urinary flow, residual urine, prostate volume, serum prostate-specific antigen or testosterone levels. Overall treatment was well tolerated with no severe adverse effects.

Conclusion: The extract of G. lucidum was well tolerated and improved IPSS scores. These results encouraged a further, large-scale evaluation of phytotherapy for a long duration using the extract of G. lucidum on men with LUTS.

Keywords: lower urinary tract symptoms, phytotherapy, outcome, randomized trial, Ganoderma lucidum

Full Text | PDF | 中文摘要 |

 
Browse:  580
Copyright 1999-2014    Shanghai Materia Medica, Shanghai Jiao Tong University.    All rights reserved