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Abstract

Volume 10, Issue 2 (March 2008) 10, 291–297; 10.1111/j.1745-7262.2008.00379.x

Herbal extracts counteract cisplatin-mediated cell death in rat testis

Amr Amin, Alaaeldin A Hamza, Amr Kambal and Sayel Daoud

1.Biology Department, United Arab Emirates University, Al-Ain 17551, United Arab Emirates
2.Hematology Laboratory, Twam Hospital, Al-Ain 15258, United Arab Emirates
3.Histopathology Laboratory, Twam Hospital, Al-Ain 15258, United Arab Emirates

Correspondence: Dr Amr Amin, Biology Department, United Arab Emirates University, Al-Ain 17551, United Arab Emirates. Fax: +971-3-7671-291. E-mail: a.amin@uaeu.ac.ae

Received 5 July 2007; Accepted 24 November 2007.

Abstract

Aim: To evaluate the protective effects of ginger (Gin) and roselle (Ros) against testicular damage and oxidative stress in a cisplatin (CIS)-induced rodent model. Their protective effects against CIS-induced apoptosis in testicular and epididymal sperms is also investigated.

Methods: Ethanol extracts of Gin or Ros (1 g/kg·day) were given orally to male albino rats for 26 days. This period began 21 days before a single CIS intraperitoneal injection (10 mg/kg body weight).

Results: Gin or Ros given orally significantly restored reproductive function. Both tested extracts notably reduced the CIS-induced reproductive toxicity, as evidenced by restoring the testis normal morphology. In Gin and Ros, the attenuation of CIS-induced damage was associated with less apoptotic cell death both in the testicular tissue and in the sperms. CIS-induced alterations of testicular lipid peroxidation were markedly improved by these plant extracts.

Conclusion: The present results provide further insights into the mechanisms of protection against CIS-induced reproductive toxicity and confirm the essential anti-oxidant potential of both examined extracts.

Keywords: cisplatin, cell death, toxicity, flow cytometry, ginger, roselle

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