Volume 10, Issue 5 (September 2008) 10, 701–709; 10.1111/j.1745-7262.2008.00433.x
Human epidermal growth factor receptor type 2 protein expression in Chinese metastatic prostate cancer patients correlates with cancer specific survival and increases after exposure to hormonal therapy
Bo Dai1,3, Yun-Yi Kong2,3, Ding-Wei Ye1,3, Chun-Guang Ma1,3, Xiao-Yan Zhou2,3 and Xu-Dong Yao1,3
1 Department of Urology, Cancer Hospital, Fudan University, Shanghai 200032, China 2 Department of Pathology, Cancer Hospital, Fudan University, Shanghai 200032, China 3 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China
Correspondence: Dr Ding-Wei Ye, Department of Urology, Cancer Hospital, Fudan University, Shanghai 200032, China. Fax: +86-21-6443-8640. E-mail: dwye@shca.org.cn
Received 6 April 2008; Accepted 1 June 2008
Abstract |
Aim: To investigate human epidermal growth factor receptor type 2 (HER2) protein expression and gene amplification in Chinese metastatic prostate cancer patients and their potential value as prognostic factors.
Methods: Immuno-histochemistry (IHC) was performed to investigate HER2 protein expression in prostate biopsy specimens from 104 Chinese metastatic prostate cancer patients. After 3–11 months of hormonal therapy, 12 patients underwent transure-thral resection of the prostate (TURP). HER2 protein expression of TURP specimens was compared with that of the original biopsy specimens. Of these, 10 biopsy and 4 TURP specimens with HER2 IHC staining scores ≥ 2+ were investigated for HER2 gene amplification status by fluorescent in situ hybridization (FISH).
Results: Of the 104 prostate biopsy specimens, HER2 protein expression was 0, 1+, 2+ and 3+ in 49 (47.1%), 45 (43.3%), 8 (7.7%) and 2 (1.9%) cases, respectively. There was a significant association between HER2 expression and Gleason score (P = 0.026). HER2 protein expression of prostate cancer tissues increased in 33.3% of patients after hormonal therapy. None of the 14 specimens with HER2 IHC scores ≥ 2+ showed HER2 gene amplification. Patients with HER2 scores ≥ 2+ had a significantly higher chance of dying from prostate cancer than those with HER2 scores of 0 (P = 0.004) and 1+ (P = 0.034). Multivariate Cox regression analysis showed that HER2 protein expression intensity was an independent predictor of cancer-related death (P = 0.039).
Conclusion: An HER2 IHC score ≥ 2+ should be defined as HER2 protein overexpression in prostate cancer. Overexpression of HER2 protein in cancer tissue might suggest an increased risk of dying from prostate cancer. HER2 protein expression increases in some individual patients after hormonal therapy.
Keywords: prostatic neoplasms, human epidermal growth factor receptor type 2, immunohistochemistry, gene amplification, prostate cancer, prognosis
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