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Volume 10, Issue 6 (November 2008) 10, 923–928; 10.1111/j.1745-7262.2008.00438.x

Clinical significance of the leptin and leptin receptor expressions in prostate tissues

Jung Hoon Kim1, Shin Young Lee1, Soon Chul Myung1, Young Sun Kim1, Tae-Hyoung Kim1 and Mi Kyung Kim2

1 Department of Urology, College of Medicine, Chung-Ang University, Seoul 140-757, Korea
2 Department of Pathology, College of Medicine, Chung-Ang University, Seoul 140-757, Korea

Correspondence: Dr Tae-Hyoung Kim, Department of Urology, College of Medicine, Chung-Ang University, 65-207, Hankang-Ro 3 Ka, Yong-san Ku, Seoul 140-757, Korea. Fax: +82-2-798-8577. E-mail: kthlmk@hanafos.com

Received 22 April 2008; Accepted 30 June 2008


Aim: To evaluate the expression of leptin and leptin receptor in benign prostatic hyperplasia (BPH) and prostate cancer (PCa), and to investigate whether they are associated with the development and progression of PCa.

Methods: Immunohistochemical staining was performed to examine the expression of leptin and leptin receptor in BPH and PCa. PCa was divided into three groups: localized PCa, locally advanced PCa and metastatic PCa. The positive staining was identified and the percentage of the positive staining was graded. We also assessed the relationship between both the Gleason score and body mass index (BMI) and PCa.

Results: The percentage of the leptin expression in PCa was significantly higher than that in BPH (P < 0.01). For the PCa group, the expressed levels of leptin showed a considerable correlation with localized PCa and metastatic PCa (P < 0.05). Leptin receptor, however, did not reveal a definite difference between BPH and PCa. The expression of leptin indicated a significant difference between well-differentiated PCa (Gleason score ≤ 6) and poorly differentiated PCa (Gleason score 8–10) (P < 0.05). The relation between the leptin expression level in PCa and the BMI was not remarkable (P = 0.447).

Conclusion: Our results suggest that leptin might have a promoting effect on the carcinogenesis and progression of PCa.

Keywords: leptin, leptin receptor, prostatic neoplasms

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