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Volume 16, Issue 2 (March 2014) 16, 268–269; 10.4103/1008-682X.122364
Long and noncoding RNAs (lnc-RNAs) determine androgen receptor dependent gene expression in prostate cancer growth in vivo
Richard G. Pestell1, Zuoren Yu2
1Department of Cancer Biology, Kimmel Cancer Center,
Thomas Jefferson University, Philadelphia, PA, USA;
2Research Center for Translational Medicine,
East Hospital, Tongji University School of Medicine,
Shanghai, China
Correspondence: Dr. RG Pestell or Dr. Z Yu
07 January 2014
| Abstract |
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Hyperactive androgen receptor (AR)
activity remains a key determinant of
the onset and progression of prostate cancer
and resistance to current therapies. The
mechanisms governing castrate resistant
prostate cancer are poorly understood, but
defi ning these molecular events is essential in
order to impact deaths from prostate cancer.
Yang et al. demonstrate that two lnc-RNAs
known to be overexpressed in therapy
resistant prostate cancer, PRNCR1 (also
known as PCAT8) and PCGEM1, bound to
the AR to enhance ligand-dependent and
ligand-independent AR gene expression and
proliferation of prostate cancer cells.1 Th e
sequence of these interactions involved the
binding of PRNCR1 to the acetylated AR
and a subsequent association of DOT1L,
which was required for the sequential
recruitment of the lncRNA PCGEM1 to
the AR amino terminus, which in turn was
methylated by DOT1L.
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