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Volume 26, Issue 3 (May 2024) 26, 328–332; 10.4103/aja202367
Effect of SARS-CoV-2 infection on semen parameters in sperm bank volunteers with normal sperm concentration
Li Wang1,2,3,4,5,6,7,8, Wen-Kai Han1,2,3,4,5,6,7,8, Xiao-Hui Song1,2,3,4,5,6,7,8, Qi-Lin Zhang1,2,3,4,5,6,7,8, An-Quan Guan1,2,3,4,5,6,7,8, Yuan Gao1,2,3,4,5,6,7,8, Jin-Long Ma1,2,3,4,5,6,7,8
1Center for Reproductive Medicine, Shandong University, Jinan 250001, China; 2State Key Laboratory of Reproductive Medicine and Offspring Health, Shandong University, Jinan 250001, China; 3Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan 250001, China; 4Shandong Key Laboratory of Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250001, China; 5Shandong Provincial Clinical Research Center for Reproductive Health, Jinan 250001, China; 6Shandong Technology Innovation Center for Reproductive Health, Jinan 250001, China; 7National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan 250001, China; 8Research Unit of Gametogenesis and
Health of ART-Offspring, Chinese Academy of Medical Sciences (No.2021RU001), Jinan 250001, China.
Correspondence: Jin-Long Ma
Received: 10 May 2023; Accepted: 16 October 2023; published online: 08 December 2023
| Abstract |
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In this study, we aimed to assess the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on semen parameters. The study comprised 110 sperm volunteers who self-reported SARS-CoV-2 infection from the Human Sperm Bank of the Center for Reproductive Medicine, Shandong University (Jinan, China). The volunteers had normal sperm concentration before infection. Each volunteer provided semen samples before and after infection. We selected 90 days after infection as the cutoff point. Semen parameters within 90 days after infection of 109 volunteers (group A) were compared with semen parameters before infection. Moreover, semen parameters on or after 90 days after infection of 36 volunteers (group B) were compared with semen parameters before infection. Furthermore, based on whether the volunteers had completed the three-dose SARS-CoV-2 vaccination booster, volunteers in group A and B were further divided into two subgroups separately. Semen parameters were compared before and after infection in each subgroup. Our results showed that in this cohort population, the semen quality in volunteers with normal sperm concentrations before infection decreased after SARS-CoV-2 infection within 90 days, while the semen quality returned to preinfection levels after 90 days. The completion of a three-dose SARS-CoV-2 vaccination booster may exert a protective effect on semen quality after infection.
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