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Abstract

Volume 16, Issue 3 (May 2014) 16, 478–481; 10.4103/1008-682X.124560

Relationships among androgen receptor CAG repeat polymorphism, sex hormones and penile length in Han adult men from China: a cross-sectional study

Yan-Min Ma1,2,*, Kai-Jie Wu1,*, Liang Ning1, Jin Zeng1, Bo Kou1,2, Hong-Jun Xie1,2, Zhen-Kun Ma1,2, Xin-Yang Wang2, Yong-Guang Gong1, Da-Lin He1,2

1 Department of Urology, First Affiliated Hospital of Medical School, Xi’an Jiaotong University, Xi’an 710061, China
2 Oncology Research Lab, Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of the People’s Republic of China, Xi’an 710061, China
* These authors contributed equally to this work.

Correspondence: Dr. YG Gong (gyg0207@sina.com) or Dr. DL He (dalinhexjtu@126.com)

Received: 05 August 2013; Revised: 23 September 2013; Accepted: 27 November 2013

Abstract

This study aimed to investigate the correlations among androgen receptor (AR) CAG repeat polymorphism, sex hormones and penile length in healthy Chinese young adult men. Two hundred and fifty-three healthy men (aged 22.8 ± 3.12 years) were enrolled. The individuals were grouped as CAG short (CAGS) if they harboured repeat length of ≤ 20 or as CAG long (CAGL) if their CAG repeat length was >20. Body height/weight, penile length and other parameters were examined and recorded by the specified physicians; CAG repeat polymorphism was determined by the PCR method; and the serum levels of the sex hormones were detected by radioimmunoassay. Student’s t-test or linear regression analysis was used to assess the associations among AR CAG repeat polymorphism, sex hormones, and penile length. This investigation showed that the serum total testosterone (T) level was positively associated with the AR CAG repeat length (P=0.01), while no significant correlation of T or AR CAG repeat polymorphism with the penile length was found (P=0.593). Interestingly, an inverse association was observed between serum prolactin (PRL) levels and penile length by linear regression analyses (β=-0.024, P=0.039, 95% CI [-0.047, 0]). Collectively, this study provides the first evidence that serum PRL, but not T or AR CAG repeat polymorphism, is correlated with penile length in the Han adult population from Northwestern China.

Keywords: androgen receptor; CAG repeat; testosterone; prolactin; penile length

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