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Abstract

Volume 17, Issue 2 (March 2015) 17, 187–191; 10.4103/1008-682X.146968

Controversies in testosterone replacement therapy: testosterone and cardiovascular disease

Kathleen Hwang, Martin Miner

1 Department of Surgery (Urology), The Alpert Medical School of Brown University, Providence, Rhode Island, USA
2 Department of Family Medicine, The Alpert Medical School of Brown University, Providence, Rhode Island, USA

Correspondence: Dr. Kathleen Hwang (kathleen_hwang@brown.edu)

2015-1-2

Abstract

The role of testosterone in the cardiovascular (CV) health of men is controversial. Data suggest that both the condition and treatment of clinical hypogonadism is associated with decreased CV mortality; however, two recent studies suggest that hypogonadal subjects treated with testosterone replacement therapy have a higher incidence of new CV events. There has been increased media attention concerning the risk of CV disease in men treated with testosterone. Until date, there are no long-term prospective studies to determine safety. Literature spanning over the past 30 years has suggested that not only is there a possible increased CV risk in men with low levels of testosterone, but the benefits from testosterone therapy may even lower this risk. We review here the recent studies that have garnered such intense scrutiny. This article is intended as a thorough review of testosterone levels and CV risk, providing the clinician with the facts needed to make informed clinical decisions in managing patients with clinical hypogonadism.

Keywords: cardiovascular disease; hypogonadism; testosterone

Keywords: cardiovascular disease; hypogonadism; testosterone

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Asian Journal of Andrology CN 31-1795/R ISSN 1008-682X  Copyright © 2023  Shanghai Materia Medica, Chinese Academy of Sciences.  All rights reserved.