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Volume 18, Issue 1 (January 2016) 18, 80–84; 10.4103/1008-682X.150254

Role of C-type natriuretic peptide in the function of normal human sperm

Hui Xia, Yao Chen, Ke-Jia Wu, Hu Zhao, Cheng-Liang Xiong, Dong-Hui Huang

1Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; 2People’s Hospital of Luoshan County,
Xinyang 464200, China; 3Department of Human Anatomy, Tongji Medical College, Hua Zhong University of Science and Technology, Wuhan 430030, China.

Correspondence: Prof. DH Huang (jhsyyjs@126.com)



C‑type natriuretic peptide (CNP) is a newly discovered type of local regulatory factor that mediates its biological effects through
the specific, membrane‑bound natriuretic peptide receptor‑B (NPR‑B). Recent studies have established that CNP is closely related
to male reproductive function. The aims of this study were to determine the distribution of CNP/NPR‑B in human ejaculated
spermatozoa through different methods (such as immunolocalization, real time polymerase chain reaction and Western Blot),
and then to evaluate the influence of CNP on sperm function in vitro, such as motility and acrosome reaction. Human semen
samples were collected from consenting donors who met the criteria of the World Health Organization for normozoospermia. Our
results show that the specific receptor NPR‑B of CNP is localized in the acrosomal region of the head and the membrane of the
front‑end tail of the sperm, and there is no signal of CNP in human sperm. Compared with the control, CNP can induce a significant
dose‑dependent increase in spermatozoa motility and acrosome reaction. In summary, CNP/NPR‑B can affect sperm motility and
acrosome reaction, thus regulating the reproductive function of males. CNP may be a new key factor in regulating sperm function.

Keywords: acrosome reaction; C‑type natriuretic peptide; natriuretic peptide receptor‑B; sperm motility

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