Home  |   Archive  |   Online Submission  |   News & Events  |   Subscribe  |   APFA  |   Society  |   Contact Us  |   中文版
Search   
 
Journal

Ahead of print
Authors' Accepted
    Manuscripts
new!
Current Issue
Archive
Acknowledgments
Special Issues
Browse by Category

Manuscript Submission

Online Submission
Online Review
Instruction for Authors
Instruction for Reviewers
English Corner new!

About AJA

About AJA
Editorial Board
Contact Us
News

Resources & Services

Advertisement
Subscription
Email alert
Proceedings
Reprints

Download area

Copyright licence
EndNote style file
Manuscript word template
Guidance for AJA figures
    preparation (in English)

Guidance for AJA figures
    preparation (in Chinese)

Proof-reading for the
    authors

AJA Club (in English)
AJA Club (in Chinese)

 
Abstract

Volume 18, Issue 1 (January 2016) 18, 80–84; 10.4103/1008-682X.150254

Role of C-type natriuretic peptide in the function of normal human sperm

Hui Xia, Yao Chen, Ke-Jia Wu, Hu Zhao, Cheng-Liang Xiong, Dong-Hui Huang

1Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; 2People’s Hospital of Luoshan County,
Xinyang 464200, China; 3Department of Human Anatomy, Tongji Medical College, Hua Zhong University of Science and Technology, Wuhan 430030, China.

Correspondence: Prof. DH Huang (jhsyyjs@126.com)

28-Apr-2015

Abstract

C‑type natriuretic peptide (CNP) is a newly discovered type of local regulatory factor that mediates its biological effects through
the specific, membrane‑bound natriuretic peptide receptor‑B (NPR‑B). Recent studies have established that CNP is closely related
to male reproductive function. The aims of this study were to determine the distribution of CNP/NPR‑B in human ejaculated
spermatozoa through different methods (such as immunolocalization, real time polymerase chain reaction and Western Blot),
and then to evaluate the influence of CNP on sperm function in vitro, such as motility and acrosome reaction. Human semen
samples were collected from consenting donors who met the criteria of the World Health Organization for normozoospermia. Our
results show that the specific receptor NPR‑B of CNP is localized in the acrosomal region of the head and the membrane of the
front‑end tail of the sperm, and there is no signal of CNP in human sperm. Compared with the control, CNP can induce a significant
dose‑dependent increase in spermatozoa motility and acrosome reaction. In summary, CNP/NPR‑B can affect sperm motility and
acrosome reaction, thus regulating the reproductive function of males. CNP may be a new key factor in regulating sperm function.

Keywords: acrosome reaction; C‑type natriuretic peptide; natriuretic peptide receptor‑B; sperm motility

Full Text | PDF | 中文摘要 |

 
Browse:  1752
 
Asian Journal of Andrology CN 31-1795/R ISSN 1008-682X  Copyright © 2023  Shanghai Materia Medica, Chinese Academy of Sciences.  All rights reserved.