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Volume 18, Issue 1 (January 2016) 18, 118–122; 10.4103/1008-682X.155533

The application of color Doppler flow imaging in the diagnosis and therapeutic effect evaluation of erectile dysfunction

Xu-Jun Xuan, Gang Bai, Cai-Xia Zhang, Chao Xu, Fu-Ding Lu, Yang Peng, Gang Ma, Cong-Hui Han, Jun Chen

1Department of Urology and Andrology, Center for Reproductive Medicine, Shandong University, Shandong Provincial Key Laboratory of Reproductive Medicine, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, The Key Laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, China; 2Department of Urology, Sun Yat‑sen Memorial Hospital, Sun Yat‑sen University, Guangzhou, Guangdong, China; 3Department of Urology, The Affiliated School of Clinical Medicine, Xuzhou Medical College, Xuzhou, China; 4Department of Infertility and Sexual Medicine, The Third Affiliated Hospital of Sun Yat‑Sen University, Guangzhou, Guangdong, China.

Correspondence: Dr. CH Han (hanchdoctor@yahoo.com.cn) or Dr. J Chen (jchen121121@hotmail.com)



We aim to investigate the correlations between hemodynamic parameters, penile rigidity grading, and the therapeutic effects of phosphodiesterase type 5 inhibitors using color Doppler flow imaging after intracavernosal injection in patients with erectile dysfunction. This study involved 164 patients. After intracavernosal injection with a mixture of papaverine (60 mg), prostaglandin E 1 (10 mg), and lidocaine (2%, 0.5-1 ml), the penile vessels were assessed using color Doppler flow imaging. Penile rigidity was classified based on the Erection Hardness Score system as Grades 4, 3, 2 or 1 (corresponding to Schramek Grades V to II). Then, the patients were given oral sildenafil (50-100 mg) and scored according to the International Index of Erectile Function (IIEF-5) questionnaire. The number of patients with penile rigidities of Schramek Grades II to V was 14, 18, 21, and 111, respectively. The IIEF-5 score was positively correlated with the refilling index of the penile cavernosal artery (r = 0.79, P< 0.05), the peak systolic velocity (r = 0.45, P< 0.05), and penile rigidity (r = 0.75, P< 0.05), and was negatively correlated with the end diastolic velocity (r = −0.74, P< 0.05). For patients with erectile dysfunction, both the IIEF-5 score after sildenafil administration, which is correlated with penile rigidity, and the hemodynamic parameters detected using color Doppler flow imaging may predict the effects of phosphodiesterase type 5 inhibitor treatment and could provide a reasonable model for the targeted-treatment of erectile dysfunction.

Keywords: color Doppler flow imaging; erectile dysfunction; hemodynamic parameters; penis rigidity; sildenafil

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